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（特に重要な文献については，番号をゴシック体で表記している．）

著者プロフィール

東天（かん どんちょん）

香椎丘リハビリテーション病院，九州大学名誉教授（大学院医学研究科臨床検査医学部分野）．医学博

士．

◆略歴 1956 年大阪市に生まれる．1982 年九州大学医学部卒業．1988 年同大 大学院医学系研究

科博士課程修了．1989 年福岡大学医学部臨床検査医学助手．1992 年 Max-Planck 研究所

研究員．1993 年九州大学医学部第 2 生化学講座助手．1996 年九州大学医学部臨床検査医

学助教授．2006 年より同大学院臨床検査医学教授．2022 年 3 月定年退職．4 月より現職．

◆研究テーマと抱負 ミトコンドリア機能維持の分子メカニズムと疾患との関連をさまざまな視点

から研究．特にミトコンドリア産生活性酸素のミトコンドリア自身への影響と細胞代謝機

能への影響には研究初期から興味を持って取り組んでいる．臨床検査医学に所属するよう

になってからは，臨床検査の標準化，医療情報データベース化，新規検査法の開発などにも

力を入れている．

◆趣味 特になし．強いて言えば一人旅．

ミトコンドリアの機能維持と疾患

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Maintaining of Mitochondria has Key Roles in Common Diseases

Dongchon KANG

Kashiigaoka Rehabiritation Hospital

Professor Emeritus, Kyushu University

Abstract

Mitochondria are responsible for about 90% of ATP synthesis in most aerobic cells, which inevitably

accompanies production of huge reactive oxygen species. Therefore, mitochondrial genome (mtDNA)

is under far more oxidative stress than nuclear genome. Resultantly, mtDNA as well as the organelle

itself suffers higher damage over age. As mitochondria are a central hub for many cellular metabolisms

including sugars, lipids, proteins, and nucleic acids in addition to energy production, the damage of

mitochondria seriously affects the cellular overall processes leading to various common diseases.

We have found Mitochondrial transcription factor A (TFAM) is a main component forming mtDNA

higher structure, so called nucleoid. We also have shown TFAM is essential for its stability in

mitochondrial matrix, in other words, protects mtDNA in vivo. Accordingly, overexpression of TFAM

increases mtDNA and has beneficial effects for many pathologic situations such as heart failure, aging,

neurodegenerative disease, diabetes, and so on.

We found p32 protein among the TFAM-binding proteins. p32 is already reported by us to be in

mitochondrial matrix and critical for oxidative phosphorylation. Through several p32 conditional

knockout mice, we have shown p32 plays critical roles in efficient mitochondrial translation, regulation

of IL6 production, antigen presentation, and differentiation to erythrocyte and B lymphocyte.

Key words : mtDNA, oxidative stress, TFAM, p32

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