第 1 章 参考文献
1 村尾澤夫 (2001) 発酵ハンドブック 第 II 部 発酵の歴史 共立出版
2 P. F. Stanbury and A. Whitaker (1988) 発酵工学の基礎 学会出版センター
3 Gregory Stephanopoulos (2002) 代謝工学: 原理と方法論 東京電機大学出版局
4 http://syntheticbiology.org/
5 https://www.genomatica.com/worlds-first-ton-of-renewable-nylon-intermediate/
6 Jullesson et al. Biotechnology Advances (2015)
7 Dae-Kyun Ro et al. Nature 440, 940-943 (2006)
8 https://synbiobeta.com/these-98-synthetic-biology-companies-raised-3-8-billion-in2018/
9 https://www.meti.go.jp/shingikai/sankoshin/shomu_ryutsu/bio/pdf/008_03_00.pdf
10 Catherine Waldby et al. Synthetic Biology in Australia: an outlook to 2030.
11 https://www.technologyreview.com/s/424786/lessons-from-sematech/
12 https://www.embs.org/pulse/articles/the-foundry-scaling-up-biological-design/
第 2 章 参考文献
13 Buleandra, M. et al. Comparative chemical analysis of Mentha piperita and M. spicata and a fast assessment of commercial peppermint teas. Nat. Prod. Commun. 11, 551–555 (2016).
14 De Carvalho, C. C. C. R. & Da Fonseca, M. M. R. Carvone: Why and how should one bother to produce this terpene. Food Chem. 95, 413–422 (2006).
15 Lawrence, B. M. A Preliminary Report on the World Production of Some Selected Essential Oils and Countries. Perfum. Flavor. 38–39 (2008).
16 Krings, U. & Berger, R. G. Biotechnological production of flavours and fragrances. Appl. Microbiol. Biotechnol. 49, 1–8 (1998).
17 Grabenhofer, R. L. Mint : Market Growth, History, Sourcing, Formulation and Characterization. Perfurmer and Flavorist (2016).
18 Jullesson, D., David, F., Pfleger, B. & Nielsen, J. Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals. Biotechnol. Adv. 33, 1395–1402 (2015).
19 Romero-Guido, C. et al. Biochemistry of lactone formation in yeast and fungi and its utilisation for the production of flavour and fragrance compounds. Appl. Microbiol. Biotechnol. 89, 535–547 (2011).
20 Karp, F., Mihaliak, C. A., Harris, J. L. & Croteau, R. Monoterpene biosynthesis: Specificity of the hydroxylations of (−)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves. Arch. Biochem. Biophys. 276, 219–226 (1990).
21 Gershenzon, J., Maffei, M. & Croteau, R. Biochemical and Histochemical Localization of Monoterpene Biosynthesis in the Glandular Trichomes of Spearmint (Mentha spicata). Plant Physiol. 89, 1351–1357 (1989).
22 Haudenschild, C., Schalk, M., Karp, F. & Croteau, R. Functional expression of regiospecific cytochrome P450 limonene hydroxylases from mint (Mentha spp.) in Escherichia coli and saccharomyces cerevisiae. Arch. Biochem. Biophys. 379, 127–36 (2000).
23 Ringer, K. L. Monoterpene Metabolism. Cloning, Expression, and Characterization of (−)-Isopiperitenol/(−)-Carveol Dehydrogenase of Peppermint and Spearmint. Plant Physiol. 137, 863–872 (2005).
24 Carter, O. A., Peters, R. J. & Croteau, R. Monoterpene biosynthesis pathway construction in Escherichia coli. Phytochemistry 64, 425–433 (2003).
25 Wei, Y., Ang, E. L. & Zhao, H. Recent developments in the application of P450 based biocatalysts. Curr. Opin. Chem. Biol. 43, 1–7 (2018).
26 Biggs, B. W. et al. Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 113, 3209–3214 (2016).
27 Gerber, S. A., Rush, J., Stemman, O., Kirschner, M. W. & Gygi, S. P. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc. Natl. Acad. Sci. U. S. A. 100, 6940–6945 (2003).
28 Brun, V. et al. Isotope-labeled protein standards: Toward absolute quantitative proteomics. Mol. Cell. Proteomics 6, 2139–2149 (2007).
29 Beynon, R. J., Doherty, M. K., Pratt, J. M. & Gaskell, S. J. Multiplexed absolute quantification in proteomics using artificial QCAT proteins of concatenated signature peptides. Nat. Methods 2, 587–589 (2005).
30 Al-Majdoub, Z. M., Carroll, K. M., Gaskell, S. J. & Barber, J. Quantification of the proteins of the bacterial ribosome using QconCAT technology. J. Proteome Res. 13, 1211– 1222 (2014).
31 Voges, R., Corsten, S., Wiechert, W. & Noack, S. Absolute quantification of Corynebacterium glutamicum glycolytic and anaplerotic enzymes by QconCAT. J. Proteomics 113, 366–377 (2015).
32 Batth, T. S. et al. A targeted proteomics toolkit for high-throughput absolute quantification of Escherichia coli proteins. Metab. Eng. 26, 48–56 (2014).
33 Nakagawa, A. et al. Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli. Nat. Commun. 6, in press (2015).
34 Toyoshima, M. et al. Targeted proteome analysis of microalgae under high-light conditions by optimized protein extraction of photosynthetic organisms. J. Biosci. Bioeng. 127, 394–402 (2019).
35 Uchida, Y. et al. A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood--brain barrier in ddY, FVB, an. Fluids Barriers CNS 10, 21 (2013).
36 Rappsilber, J., Mann, M. & Ishihama, Y. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat. Protoc. 2, 1896–1906 (2007).
37 Ishihama, Y., Rappsilber, J. & Mann, M. Modular stop and go extraction tips with stacked disks for parallel and multidimensional peptide fractionation in proteomics. J. Proteome Res. 5, 988–994 (2006).
38 Rappsilber, J., Ishihama, Y. & Mann, M. Stop And Go Extraction tips for matrix assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics. Anal. Chem. 75, 663–670 (2003).
39 Matsuda, F., Ogura, T., Tomita, A., Hirano, I. & Shimizu, H. Nano-scale liquid chromatography coupled to tandem mass spectrometry using the multiple reaction monitoring mode based quantitative platform for analyzing multiple enzymes associated with central metabolic pathways of Saccharomyces cerevisiae using ultra . J. Biosci. Bioeng. 119, 117–120 (2015).
40 Matsuda, F., Kinoshita, S., Nishino, S., Tomita, A. & Shimizu, H. Targeted proteome analysis of single-gene deletion strains of Saccharomyces cerevisiae lacking enzymes in the central carbon metabolism. PLoS One 12, 1–20 (2017).
41 Matsuda, F., Tomita, A. & Shimizu, H. Prediction of Hopeless Peptides Unlikely to be Selected for Targeted Proteome Analysis. Mass Spectrom. 6, A0056–A0056 (2017).
42 MacLean, B. et al. Skyline: An open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics 26, 966–968 (2010).
43 Van Der Werf, M. J. & Boot, A. M. Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14. Microbiology 146, 1129–1141 (2000).
44 Alonso-gutierrez, J. et al. Principal component analysis of proteomics ( PCAP ) as a tool to direct metabolic engineering. Metab. Eng. 28, 123–133 (2015).
45 Takemori, N. et al. MEERCAT: Multiplexed Efficient Cell Free expression of recombinant qconcats for large scale absolute proteome quantification. Mol. Cell. Proteomics 16, 2169–2183 (2017).
46 Johnson, J. et al. Construction of à la carte QconCAT protein standards for multiplexed quantification of user-specified target proteins. BMC Biol. 19, 1–16 (2021).
47 Buleandra, M. et al. Comparative chemical analysis of Mentha piperita and M. spicata and a fast assessment of commercial peppermint teas. Nat. Prod. Commun. 11, 551–555 (2016).
48 Du, F.-L., Yu, H.-L., Xu, J.-H. & Li, C.-X. Enhanced limonene production by optimizing the expression of limonene biosynthesis and MEP pathway genes in E. coli. Bioresour. Bioprocess. 1, 10 (2014).
49 Alonso-Gutierrez, J. et al. Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. Metab. Eng. 19, 33–41 (2013).
50 Satoh, Y., et al. Engineering of L-tyrosine oxidation in Escherichia coli and microbial production of hydroxytyrosol. Metabolic Engineering, 14(6), 603–10. (2012).
事業戦略 参考文献
51 コトラー&ケラーのマーケティング・マネジメント 第 12 版、丸善出版(2014)
52https://obamawhitehouse.archives.gov/sites/default/files/microsites/ostp/national_bioeconomy_blueprint_april_2012.pdf
53 https://www.energy.gov/sites/default/files/2016/02/f30/farb_2_18_16.pdf
54 https://www.oecd.org/futures/longtermtechnologicalsocietalchallenges/thebioeconomyto2030designingapolicyagenda.htm
55https://www.ecsite.eu/sites/default/files/201202_innovating_sustainable_growth_en.pdf
56 https://www.switchtogreen.eu/a-sustainable-bioeconomy-for-europe-strengtheningthe-connection-between-economy-society-and-the-environment/
57 https://www.kantei.go.jp/jp/singi/tougou-innovation/pdf/biosenryaku2019.pdf
58 https://www8.cao.go.jp/cstp/bio/bio2020_honbun.pdf
59 Review of the 2012 European Bioeconomy Strategy
60 https://www.aip.org/fyi/2017/final-fy17-appropriations-doe-applied-energy
61 https://www.darpa.mil/program/living-foundries
62 https://ec.europa.eu/programmes/horizon2020/
63 http://english.tib.cas.cn/
64 http://english.qibebt.cas.cn/
65 https://response.jp/release/kyodonews_kaigai/20160923/28685.html
66 https://www.biopreferred.gov/BioPreferred/faces/pages/AboutBioPreferred.xhtml
67 https://www.boi.go.th/upload/content/BOI_brochure_BioEconomy.pdf
68 https://www.epa.gov/stationary-sources-air-pollution/affordable-clean-energy-rule
69 https://www.afpbb.com/articles/-/3159908
70 https://ec.europa.eu/environment/topics/plastics/plastic-bags_en
71 https://ec.europa.eu/environment/topics/plastics/single-use-plastics_en
72 https://www.meti.go.jp/policy/recycle/plasticbag/plasticbag_top.html
73https://ec.europa.eu/info/sites/default/files/2018_11_gcsa_statement_gene_editing_1.pdf
74 https://www.usda.gov/media/press-releases/2018/03/28/secretary-perdue-issues-usdastatement-plant-breeding-innovation
75https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/shokuhin/bio/genomed/index_00012.html
76 https://www.alic.go.jp/content/001172226.pdf
77 https://www.nikkei.com/article/DGXZQOFB107EH0Q0A211C2000000/
78 JETRO 地域・分析レポート “未曽有の危機下で日本企業が模索する海外ビジネス”https://www.jetro.go.jp/biz/areareports/special/2021/0203/00c814af761ce40e.htm
79 https://www.whitehouse.gov/briefing-room/statements-releases/2021/01/25 presidentbiden-to-sign-executive-order-strengthening-buy-american-provisions-ensuring-futureof-america-is-made-in-america-by-all-of-americas-workers/
80 https://jp.wsj.com/articles/SB12250169213134644233904586415512724911644
81 https://jp.reuters.com/article/covid-trade-war-idJPKBN24114W
82 https://www.reuters.com/article/usa-china-visas-idUSKBN2602SH
83 https://synbiobeta.com/these-98-synthetic-biology-companies-raised-3-8-billion-in2018/
84 https://www.meti.go.jp/shingikai/sankoshin/shomu_ryutsu/bio/pdf/008_03_00.pdf
85 https://www.foodnavigator.com/Article/2021/03/24/Has-the-alternative-meat-marketbeen-slowed-by-COVID-Redefine-Meat-thinks-not#
86 BCG レポート “グローバル・サプライチェーンのレジリエンスを高める” https://web-assets.bcg.com/a1/bf/47fffff74950852e089dcf27d9a2/designing-resilience-118into-global-supply-chains-j-sept2020.pdf
87 https://www.naturalproductsinsider.com/contract-manufacturing/contractmanufacturers-reflect-2020-challenges-eye-new-normal
88 https://eos.org/features/opportunities-and-challenges-of-virtual-meetings
89 https://enevolv.com/news/enevolv-acquired-by-zymergen
90 https://agfundernews.com/perfect-day-closes-140m-series-c-led-by-temasek-to-scaledairy-alternatives.html
91 https://www.undp.org/content/undp/en/home/sustainable-development-goals.html
92 https://www.bbc.com/japanese/56841289
93 https://www.bbc.com/news/world-europe-49918719
94 https://www.nytimes.com/2020/01/11/opinion/climate-change-bank-investment.html
95 バイオテクノロジーが拓く『第五次産業革命』産業構造審議会 商務流通情報分科会バイオ小委員会レポート (2021 年 2 月)
96 https://www.newfoodmagazine.com/article/91202/controlling-contaminants-the-newfacet-of-clean-label/
97 https://www.northshore.org/healthy-you/vegan-flexitarian-vegetarian-pescatarianand-macrobiotic-diets--whats-the-difference/
98 https://www.nongmoproject.org/
99 https://theconversation.com/science-communication-is-more-important-than-everhere-are-3-lessons-from-around-the-world-on-what-makes-it-work-147670
100 https://www.oecd.org/sti/science-technology-innovation-outlook/Science-adviceCOVID/
101 https://www3.nhk.or.jp/news/html/20210915/k10013259991000.html
102 https://camp-fire.jp/projects/view/400934
103 https://stryber.com/d2c-food-beverage-industry/
104 https://xtrend.nikkei.com/atcl/contents/18/00377/00001/
105 http://www.ecolabelindex.com/ecolabels/
106 https://perfectdayfoods.com/faq/
107 https://www.inscripta.com/
108 https://www.synthego.com/
109 https://www.mizuhobank.co.jp/corporate/bizinfo/industry/sangyou/m1065.html
110 https://strateos.com/
111 https://opentrons.com/
112 https://www.culturebiosciences.com/
113 https://benchling.com
114 https://riffyn.com/about
115 https://teselagen.com/
116 https://www.globenewswire.com/news-release/2016/10/04/876900/19847/en/Amyrisand-Autodesk-Offer-Powerful-Open-Source-Tools-for-Genetic-Design-to-Enable-RapidDNA-Engineering.html
117 https://www.mizuhobank.co.jp/corporate/bizinfo/industry/sangyou/pdf/1065_06.pdf
118 味の素グループの 100 年史第六章https://www.ajinomoto.co.jp/company/jp/aboutus/history/pdf/his06.pdf
119 味の素グループの 100 年史第七章https://www.ajinomoto.co.jp/company/jp/aboutus/history/pdf/his07.pdf
120 味の素(株)の戦後のグローバル化経営https://www.jstage.jst.go.jp/article/bhsj/46/3/46_3_3/_pdf
121 味の素(株)プレスリリース 「味の素(株)、中国・梅花(メイフア)生物科技集団と飼料用アミノ酸製造委託契約を締結」2017 年 8 月 3 日https://www.ajinomoto.co.jp/company/jp/presscenter/press/detail/2017_08_03.html
122 味の素(株)プレスリリース 「味の素㈱、欧州の飼料用アミノ酸会社の全株式を売却119予定」2021 年 2 月 26 日https://www.ajinomoto.co.jp/company/jp/presscenter/press/detail/2021_02_26_02.html
123 味の素グループの軌跡 2009-2019 年度 第 II 章https://www.ajinomoto.co.jp/company/jp/aboutus/history/pdf/2nd-century_01.pdf
124 味の素(株)プレスリリース 「味の素(株)と(株)ブリヂストン バイオマス由来の合成ゴムを共同開発」2012 年 5 月 31 日https://www.ajinomoto.co.jp/company/jp/presscenter/press/detail/2012_05_31_2.html
125 味の素(株)プレスリリース 「味の素(株)、長谷川香料(株)と発酵ナチュラルフレーバー事業において業務提携」2015 年 8 月 18 日https://www.ajinomoto.co.jp/company/jp/presscenter/press/detail/2015_08_18.html
126 https://ajibio-pharma.com/cdmo-services/large-molecule-manufacturing/
127 フードテック革命(日経 BP 社)
128 味の素(株)プレスリリース ~当社初のオープン&リンクイノベーションの推進拠点~ クライアント・イノベーション・センター、6月1日開設 最新のICT技術を導入し、ビジネスパートナーと新価値・新事業を共創 2018 年 5 月 28 日https://www.ajinomoto.co.jp/company/jp/presscenter/press/detail/2018_05_28.html
129 味の素(株)プレスリリース 「味の素(株)、社外向けアクセラレータ―プログラム「Ajinomoto Group Accelerator」を開始~6月17日より募集を実施~」2020 年 6 月 17日https://www.ajinomoto.co.jp/company/jp/presscenter/press/detail/2020_06_17.html
130 味の素(株)プレスリリース 味の素㈱、コーポレートベンチャーキャピタルを新設~「食と健康の課題解決」への価値創造に向け、事業モデル変革を牽引~ 2020 年 12 月16 日https://www.ajinomoto.co.jp/company/jp/presscenter/press/detail/2020_12_16.html
131 「マイケル・ポーターの競争戦略」マグレッタ
132 https://gfi.org/resource/fermentation-state-of-the-industry-report/ (該当箇所は 62 ページ目)
133 https://blog.culturebiosciences.com/scaleup#:~:text=Scaling%20Up%20from%20Culture%E2%80%99s%20250mL%20Reactors%20to%205%2C000L,next%20generation%20of%20sustainable%20materials%20made%20from%20microbes.
134 http://www.bbeu.org/pilotplant/
135 https://www.bpf.eu/
136 https://www.igb.fraunhofer.de/en/research/industrial-biotechnology/bioprocessengineering/optimization-and-scale-up-of-fermentative-production-of-chemicals.html
137 https://abpdu.lbl.gov/
138 https://www.sirim.my/sirim-ibrc/Pages/bioprocess-tech-section.aspx
139 https://www.nedo.go.jp/activities/ZZJP_100170.html
140 https://www.planet-b.io/
141 マイケル・ポーター「競争優位の戦略」1985
142 「企業戦略論(上)」ジェイ・B・バーニー
143 https://www.ajinomoto.co.jp/company/jp/aboutus/numbers/
144 https://www.ajibio-pharma.com/cdmo-services/large-moleculemanufacturing/microbial-expression-systems/
145 味の素(株)プレスリリース 「味の素(株)、米国のバイオ医薬品の開発・製造受託会社の全株式取得完了 新社名「味の素アルテア社」としてスタート」2013 年 4 月 5 日 https://www.ajinomoto.co.jp/company/jp/presscenter/press/detail/2013_04_05.html
技術戦略 参考文献
146 A new method of locating the maximum point of an arbitrary multipeak curve in the presence of noise, H. J. Kushner, J. Basic Eng., Vol 86, No. 1, Mar 1964
147 Machine-learning guided mutagenesis for directed evolution of fluorescent proteins. Y. saito et al., ACS synth Biol., Vol. 8, No. 9, Sep 2018
148 Prediction of low-thermal conductivity compounds with first-principles anharmonic lattice-dynamics calculations and Bayesian optimization. A. Seko et. al. Phys. Rev. Lett., Vol. 115, Nov 2015
149 Rapid Bayesian optimization for synthesis of short polymer fiber materials. C. Li et al. Scientific reports, Vol. 7, No. 5683, Jul 2017
150 https://www.nedo.go.jp/activities/ZZJP_100170.html
知財戦略 参考文献
151 https://www.gyoumuitakukeiyakusho.com/license-of-patent-right-in-outsourcingcontract/
財務戦略 参考文献
152 https://synbiobeta.com/these-98-synthetic-biology-companies-raised-3-8-billion-in2018/
153 超入門 企業価値経営 実践コーポレート・ファイナンス(中央経済社)
154 味の素株式会社 第 142 期 有価証券報告書
結語 参考文献
155 https://vegnews.com/2021/4/impossible-foods-to-go-public-10-billion-ipo