Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina.

1. Solter D, Knowles BB (1978) Monoclonal antibody defining a

stage-specific mouse embryonic antigen (SSEA-1). Proc Natl

Acad Sci USA 78:5565–5569

2. Bird JM, Kimber SJ (1984) Oligosaccharides containing fucose

linked α(1–3) and α(1–4) to N-acetylglucosamine cause decompaction of mouse morulae. Dev Biol 104:449–460

3. Muramatsu T (1988) Alterations of cell-surface carbohydrates

during differentiation and development. Biochimie 70:1587–1596

4. Toumadje A, Kusumoto K, Parton A, Mericko P, Dowell L, Ma

G, Chen L, Barnes DW, Sato JD (2003) Pluripotent differentiation

in vitro of murine ES-D3 embryonic stem cells. In Vitro Cell Dev

Biol Anim 39:449–453

5. Capela A, Temple S (2002) LeX/SSEA-1 is expressed by adult

mouse CNS stem cells, identifying them as nonependymal. Neuron 35:865–875

6. Nishihara S, Iwasaki H, Nakajima K, Togayachi A, Ikehara Y,

Kudo T, Kushi Y, Furuya A, Shitara K, Narimatsu H (2003) α1,3fucosyltransferase IX (Fut9) determines lewis X expression in

brain. Glycobiol 13:445–455

7. Kumar A, Torii T, Ishino Y, Muraoka D, Yoshimura T, Togayachi

A, Narimatsu H, Ikenaka K, Hitoshi S (2013) The lewis X-related

α1,3-fucosyltransferase, Fut10, is required for the maintenance of

stem cell populations. J Biol Chem 288:28859–28868

8. Yagi H, Yanagisawa M, Kato K, Yu RK (2010) Lysosome-associated membrane protein 1 is a major SSEA-1-carrier protein in

mouse neural stem cells. Glycobiology 20:976–981

9. Yagi H, Saito T, Yanagisawa M, Yu RK, Kato K (2012) Lewis

X-carrying N-glycans regulate the proliferation of mouse embryonic neural stem cells via the notch signaling pathway. J Biol

Chem 287:24356–24364

10. Kudo T, Kaneko M, Iwasaki H, Togayachi A, Nishihara S,

Abe K, Narimatsu H (2004) Normal embryonic and germ cell

18. 19. 20. 21. 22. 23. 24. 25. 26. development in mice lacking α1,3-fucosyltransferase IX (Fut9)

which show disappearance of stage specific embryonic antigen 1.

Mol Cell Biol 24:4221–4228

Kudo T, Fujii T, Ikegami S, Inokuchi K, Takayama Y, Ikehara

Y, Nishihara S, Togayachi A, Takahashi S, Tachibana K, Yuasa

S, Narimatsu H (2007) Mice lacking α1,3-fucosyltransferase

IX demonstrate disappearance of lewis x structure in brain and

increased anxiety-like behaviors. Glycobiology 17:1–9

Schizophrenia Working Group of the Psychiatric Genomics

Consortium (2014) Biological insights from 108 schizophreniaassociated genetic loci. Nature 511:421–427

Goes FS, McGrath J, Avramopoulos D, Wolyniec P, Pirooznia

M, Ruczinski I, Nestadt G, Kenny EE, Vacic V, Peters I, Lencz T,

Darvasi A, Mulle JG, Warren ST, Pulver AE (2015) Genome-wide

association study of schizophrenia in Ashkenazi Jews. Am J Med

Genet B 168:649–659

Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke

S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML

(2018) Common schizophrenia alleles are enriched in mutationintolerant genes and in regions under strong background selection.

Nat Genet 50:381–389

Lam M, Chen C-Y, Li Z, Martin AR, Bryois J, Ma X, Gaspar H,

Ikeda M, Benyamin B, Brown BC (2019) Comparative genetic

architectures of schizophrenia in east Asian and European populations. Nat Genet 51:1670–1678

Yao X, Glessner JT, Li J, Qi X, Hou X, Zhu C, Li X, March

ME, Yang L, Mentch FD, Hain HS, Meng X, Xia Q, Hakonarson H, Li J (2021) Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders. Transl Psychiatry 11:69

Naruse M, Ishino Y, Kumar A, Ono K, Takebayashi H, Yamaguchi M, Ishizaki Y, Ikenaka K, Hitoshi S (2016) The dorsoventral

boundary of the germinal zone is a specialized niche for the generation of cortical oligodendrocytes during a restricted temporal

window. Cereb Cortex 26:2800–2810

Ishino Y, Hayashi Y, Naruse M, Tomita K, Sanbo M, Fuchigami

T, Fujiki R, Hirose K, Toyooka Y, Fujimori T, Ikenaka K, Hitoshi

S (2014) Bre1a, a histone H2B ubiquitin ligase, regulates the cell

cycle and differentiation of neural precursor cells. J Neurosci

34:3067–3307

Hayashi Y, Nihonmatsu-Kikuchi N, Yu X, Ishimoto K, Hisanaga

SI, Tatebayashi Y (2011) A novel, rapid, quantitative cell-counting

method reveals oligodendroglial reduction in the frontopolar cortex in major depressive disorder. Mol Psychiatry 16:1155–1158

Molyneaux BJ, Brettler AC, Chen H-H, Hrvatin S, Rinn JL, P,

(2015) DeCoN: genome-wide analysis of in vivo transcriptional

dynamics during pyramidal neuron fate selection in neocortex.

Neuron 85:275–288

Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg

SL (2013) TopHat2: accurate alignment of transcriptomes in the

presence of insertions, deletions and gene fusions. Genome Biol

14:R36

Liao Y, Smyth GK, Shi W (2014) featureCounts: an efficient general purpose program for assigning sequence reads to genomic

features. Bioinformatics 30:923–930

Zhou X, Lindsay H, Robinson MD (2014) Robustly detecting differential expression in RNA sequencing data using observation

weights. Nucleic Acids Res 42:e91

Agirman G, Broix L, Nguyen L (2017) Cerebral cortex development: an outside-in perspective. FEBS Lett 591:3978–3992

Garcia-Frigola C, Carreres MI, Vegar C, Herrera E (2007) Gene

delivery into mouse retinal ganglion cells by in utero electroporation. BMC Dev Biol 7:1–10

Chaubey S, Wolfe JH (2013) Transplantation of CD15-enriched

murine neural stem cells increases total engraftment and shifts

13

differentiation toward the oligodendrocyte lineage. Stem Cells

Transl Med 2:444–454

27. Luque-Molina I, Khatri P, Schmidt-Edelkraut U, Simeonova IK,

Hölzl-Wenig G, Mandl C, Ciccolini F (2017) Bone morphogenetic protein promotes lewis x stage-specific embryonic antigen

1 expression thereby interfering with neural precursor and stem

cell proliferation. Stem Cells 35:2417–2429

2 8. Benes FM, Davidson J, Bird ED (1986) Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch Gen

Psychiatry 43:31–35

29. Chana G, Landau S, Beasley C, Everall IP, Cotter D (2003)

Two-dimensional assessment of cytoarchitecture in the anterior

13

Neurochemical Research

cingulate cortex in major depressive disorder, bipolar disorder,

and schizophrenia: evidence for decreased neuronal somal size

and increased neuronal density. Biol Psychiatry 53:1086–1098

30. Jakobs TC, Ben Y, Masland RH (2003) CD15 immunoreactive

amacrine cells in the mouse retina. J Comp Neurol 465:361–371

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