1. Harrison, P. J. & Weinberger, D. R. Schizophrenia genes, gene expression, and neuropathology: On the matter of their convergence. Mol. Psychiatry 10, 40–68 (2005).
2. Pittenger, C. & Duman, R. S. Stress, depression, and neuroplasticity: A convergence of mechanisms. Neuropsychopharmacology 33, 88–109 (2008).
3. Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat. Neurosci. 8, 1263–8 (2005).
4. Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S. & Roth, B. L. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl. Acad. Sci. USA 104, 5163–5168 (2007).
5. Gomez, J. L. et al. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine. Science. 357, 503–507 (2017).
6. Nakamura, K., Matsumoto, M. & Hikosaka, O. Reward-dependent modulation of neuronal activity in the primate dorsal raphe nucleus. J. Neurosci. 28, 5331–43 (2008).
7. Isa, T., Yamane, I., Hamai, M. & Inagaki, H. Japanese macaques as laboratory animals. Exp. Anim. 58, 451–457 (2009).
8. Knobloch, H. S. et al. Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron 73, 553–566 (2012).
9. Nishitani, N. et al. Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats. Neuropsychopharmacology 44, 721–732 (2019).
10. Madisen, L. et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13, 133–40 (2010).
11. Madisen, L. et al. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat. Neurosci. 15, 793–802 (2012).
12. Diester, I. et al. An optogenetic toolbox designed for primates. Nat. Neurosci. 14, 387–97 (2011).
13. Klein, C. et al. Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex. Neuron 90, 143–151 (2016).
14. Stauffer, W. R. et al. Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques. Cell 166, 1564-1571.e6 (2016).
15. El-Shamayleh, Y., Kojima, Y., Soetedjo, R. & Horwitz, G. D. Selective Optogenetic Control of Purkinje Cells in Monkey Cerebellum. Neuron 95, 51-62.e4 (2017).
16. Dermitzakis, E. T. & Clark, A. G. Evolution of transcription factor binding sites in Mammalian gene regulatory regions: conservation and turnover. Mol. Biol. Evol. 19, 1114–21 (2002).
17. Benzekhroufa, K., Liu, B. H., Teschemacher, A. G. & Kasparov, S. Targeting central serotonergic neurons with lentiviral vectors based on a transcriptional amplification strategy. Gene Ther. 16, 681–688 (2009).
18. Takahashi, A., Nagayasu, K., Nishitani, N., Kaneko, S. & Koide, T. Control of intermale aggression by medial prefrontal cortex activation in the mouse. PLoS One 9, e94657 (2014).
19. Lein, E. S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168–176 (2007).
20. Ovcharenko, I., Loots, G. G., Hardison, R. C., Miller, W. & Stubbs, L. zPicture: Dynamic alignment and visualization tool for analyzing conservation profiles. Genome Res. 14, 472–477 (2004).
21. Lucki, I. The spectrum of behaviors influenced by serotonin. Biol. Psychiatry 44, 151–162 (1998).
22. Picciotto, M. R., Higley, M. J. & Mineur, Y. S. Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron 76, 116–129 (2012).
23. Albin, R. L., Young, A. B. & Penney, J. B. The functional anatomy of basal ganglia disorders. Trends Neurosci. 12, 366–75 (1989).
24. Balleine, B. W., Delgado, M. R. & Hikosaka, O. The Role of the Dorsal Striatum in Reward and Decision-Making. J. Neurosci. 27, 8161–8165 (2007).
25. Samaranch, L. et al. Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates. Hum. Gene Ther. 23, 382–389 (2012).
26. Oguchi, M. et al. Double virus vector infection to the prefrontal network of the macaque brain. PLoS One 10, 1–15 (2015).
27. Hastie, E. & Samulski, R. J. Adeno-Associated Virus at 50: A Golden Anniversary of Discovery, Research, and Gene Therapy Success—A Personal Perspective. Hum. Gene Ther. 26, 257–265 (2015).
28. Naso, M. F., Tomkowicz, B., Perry, W. L. & Strohl, W. R. Adeno-Associated Virus (AAV) as a Vector for Gene Therapy. BioDrugs 31, 317–334 (2017).
29. Wu, Z., Yang, H. & Colosi, P. Effect of genome size on AAV vector packaging. Mol. Ther. 18, 80–86 (2010).
30. Lentz, T. B., Gray, S. J. & Samulski, R. J. Viral vectors for gene delivery to the central nervous system. Neurobiol. Dis. 48, 179–188 (2012).
31. Costello, C. G. Depression: Loss of Reinforcers or Loss of Reinforcer Effectiveness? - Republished Article. Behav. Ther. 47, 595–599 (2016).
32. Pizzagalli, D. A., Iosifescu, D., Hallett, L. A., Ratner, K. G. & Fava, M. Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task. J. Psychiatr. Res. 43, 76–87 (2008).
33. Der-Avakian, A. & Markou, A. The neurobiology of anhedonia and other reward-related deficits. Trends Neurosci. 35, 68–77 (2012).
34. Hall, G. B. C., Milne, A. M. B. & MacQueen, G. M. An fMRI study of reward circuitry in patients with minimal or extensive history of major depression. Eur. Arch. Psychiatry Clin. Neurosci. 264, 187–198 (2014).
35. Strauss, G. P., Waltz, J. A. & Gold, J. M. A review of reward processing and motivational impairment in schizophrenia. Schizophrenia Bulletin 40, 107–116 (2014).
36. Spanagel, R. & Weiss, F. The dopamine hypothesis of reward: Past and current status. Trends Neurosci. 22, 521–527 (1999).
37. Wise, R. A. Dopamine, learning and motivation. Nat. Rev. Neurosci. 5, 483–494 (2004).
38. Kirby, L. G., Zeeb, F. D. & Winstanley, C. A. Contributions of serotonin in addiction vulnerability. Neuropharmacology 61, 421–432 (2011).
39. Liu, Z. et al. Dorsal raphe neurons signal reward through 5-HT and glutamate. Neuron 81, 1360–1374 (2014).
40. Li, Y. et al. Serotonin neurons in the dorsal raphe nucleus encode reward signals. Nat. Commun. 7, (2016).
41. Wang, H. L. et al. Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons. Cell Rep. 26, 1128-1142.e7 (2019).
42. Rompre, P. P. & Miliaressis, E. Pontine and mesencephalic substrates of self-stimulation. Brain Res. 359, 246–259 (1985).
43. Rompré, P. P. & Boye, S. Localization of reward-relevant neurons in the pontine tegmentum: a moveable electrode mapping study. Brain Res. 496, 295–302 (1989).
44. Van Der Kooy, D., Fibiger, H. C. & Phillips, A. G. An analysis of dorsal and median raphe self-stimulation: Effects of para-chlorophenylalanine. Pharmacol. Biochem. Behav. 8, 441–445 (1978).
45. Fakhoury, M., Rompré, P. P. & Boye, S. M. Role of the dorsal diencephalic conduction system in the brain reward circuitry. Behav. Brain Res. 296, 431–441 (2016).
46. Weixin, Z., Li, Y., Feng, Q. & Luo, M. Learning and Stress Shape the Reward Response Patterns of Serotonin Neurons. J. Neurosci. 37, 1181–17 (2017).
47. Harrison, A. A., Liem, Y. T. B. & Markou, A. Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Neuropsychopharmacology 25, 55–71 (2001).
48. Rocha, B. A. et al. Cocaine self-administration in dopamine-transporter knockout mice. Nat. Neurosci. 1, 132–7 (1998).
49. Hnasko, T. S., Sotak, B. N. & Palmiter, R. D. Cocaine-conditioned place preference by dopamine-deficient mice is mediated by serotonin. J. Neurosci. 27, 12484–12488 (2007).
50. De Deurwaerdère, P. & Di Giovanni, G. Serotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications. Prog. Neurobiol. 151, 175–236 (2017).
51. Azmitia, E. C. & Segal, M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179, 641–667 (1978).
52. Ishimura, K. et al. Quantitative analysis of the distribution of serotonin-immunoreactive cell bodies in the mouse brain. Neurosci. Lett. 91, 265–270 (1988).
53. Luo, M., Zhou, J. & Liu, Z. Reward processing by the dorsal raphe nucleus: 5-HT and beyond. Learn. Mem. 22, 452–460 (2015).
54. McDevitt, R. A. et al. Serotonergic versus nonserotonergic dorsal raphe projection neurons: Differential participation in reward circuitry. Cell Rep. 8, 1857–1869 (2014).
55. Fonseca, M. S., Murakami, M. & Mainen, Z. F. Activation of dorsal raphe serotonergic neurons promotes waiting but is not reinforcing. Curr. Biol. 25, 306–315 (2015).
56. Ohmura, Y., Tanaka, K. F., Tsunematsu, T., Yamanaka, A. & Yoshioka, M. Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice. Int. J. Neuropsychopharmacol. 17, 1777–1783 (2014).
57. Zhang, T. et al. Glutamatergic neurons in the medial prefrontal cortex mediate the formation and retrieval of cocaine-associated memories in mice. Addict. Biol. 25, 1–11 (2020).
58. Zhang, T. et al. Activation of GABAergic Neurons in the Nucleus Accumbens Mediates the Expression of Cocaine-Associated Memory. Biol. Pharm. Bull. 41, 1084–1088 (2018).
59. Tzschentke, T. M. Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues. Prog. Neurobiol. 56, 613–672 (1998).
60. Hochbaum, D. R. et al. All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nat. Methods 11, 825–33 (2014).
61. Vertes, R. P. A PHA‐L analysis of ascending projections of the dorsal raphe nucleus in the rat. J. Comp. Neurol. 313, 643–668 (1991).
62. Muzerelle, A., Scotto-Lomassese, S., Bernard, J. F., Soiza-Reilly, M. & Gaspar, P. Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5–B9) to the forebrain and brainstem. Brain Struct. Funct. 221, 535–561 (2016).
63. Miyazaki, K. W. et al. Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards. Curr. Biol. 24, 2033–2040 (2014).
64. Miyazaki, K. et al. Reward probability and timing uncertainty alter the effect of dorsal raphe serotonin neurons on patience. Nat. Commun. 9, 2048 (2018).
65. Mattis, J. et al. Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins. Nat. Methods 9, 159–72 (2011).
66. Byerley, W. F., Reimherr, F. W., Wood, D. R. & Grosser, B. I. Fluoxetine, a selective serotonin uptake inhibitor, for the treatment of outpatients with major depression. J. Clin. Psychopharmacol. 8, 112–5 (1988).
67. Muijen, M., Roy, D., Silverstone, T., Mehmet, A. & Christie, M. A comparative clinical trial of fluoxetine, mianserin and placebo in depressed outpatients. Acta Psychiatr. Scand. 78, 384–90 (1988).
68. Feighner, J. P. & Overø, K. Multicenter, placebo-controlled, fixed-dose study of citalopram in moderate-to-severe depression. J. Clin. Psychiatry 60, 824–30 (1999).
69. Ressler, K. J. & Nemeroff, C. B. Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders. Depress. Anxiety 12 Suppl 1, 2–19 (2000).
70. Ren, J. et al. Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell 1–16 (2018). doi:10.1016/j.cell.2018.07.043
71. Browne, C. J. et al. Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition. Neuropsychopharmacology 44, 793–804 (2019).
72. Tanaka, K. F. et al. Expanding the Repertoire of Optogenetically Targeted Cells with an Enhanced Gene Expression System. Cell Rep. 2, 397–406 (2012).
73. Grimm, D. et al. In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses. J. Virol. 82, 5887–5911 (2008).
74. Jacobs, B. L. & Azmitia, E. C. Structure and function of the brain serotonin system. Physiol. Rev. 72, 165–230 (1992).
75. Charara, A. & Parent, A. Chemoarchitecture of the primate dorsal raphe nucleus. J. Chem. Neuroanat. 15, 111–27 (1998).
76. Gras, C. et al. A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J. Neurosci. 22, 5442–5451 (2002).
77. Hioki, H. et al. Vesicular glutamate transporter 3-expressing nonserotonergic projection neurons constitute a subregion in the rat midbrain raphe nuclei. J. Comp. Neurol. 518, 668–686 (2010).
78. Ren, J. et al. Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei. Elife 8, 1–36 (2019).
79. Tzschentke, T. M. & Schmidt, W. J. Functional heterogeneity of the rat medial prefrontal cortex: Effects of discrete subarea-specific lesions on drug-induced conditioned place preference and behavioural sensitization. Eur. J. Neurosci. 11, 4099–4109 (1999).
80. Otis, J. M., Dashew, K. B. & Mueller, D. Neurobiological dissociation of retrieval and reconsolidation of cocaine-associated memory. J. Neurosci. 33, 1271–1281 (2013).
81. Hayashi, K., Nakao, K. & Nakamura, K. Appetitive and aversive information coding in the primate dorsal raphé nucleus. J. Neurosci. 35, 6195–6208 (2015).
82. Tan, K. R. et al. GABA neurons of the VTA drive conditioned place aversion. Neuron 73, 1173–83 (2012).
83. Solecki, W. B. et al. Effects of brief inhibition of the ventral tegmental area dopamine neurons on the cocaine seeking during abstinence. Addict. Biol. 1–13 (2019). doi:10.1111/adb.12826
84. Di Giovanni, G. & De Deurwaerdère, P. New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders. Pharmacol. Ther. 157, 125–162 (2016).
85. Kupfer, D. J., Frank, E. & Phillips, M. L. Major depressive disorder: New clinical, neurobiological, and treatment perspectives. Lancet 379, 1045–1055 (2012).
86. Mann, J. J. Role of the serotonergic system in the pathogenesis of major depressionand suicidal behavior. Neuropsychopharmacology 21, 99S-105S (1999).
87. Köhler, S., Cierpinsky, K., Kronenberg, G. & Adli, M. The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants. J. Psychopharmacol. 30, 13–22 (2016).
88. Teissier, A. et al. Activity of Raphé Serotonergic Neurons Controls Emotional Behaviors. Cell Rep. 13, 1965–1976 (2015).
89. Sagi, Y. et al. Emergence of 5-HT5A signaling in parvalbumin neurons mediates delayed antidepressant action. Mol. Psychiatry 25, 1191–1201 (2020).
90. Katz, M. M. et al. Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression. Neuropsychopharmacology 29, 566–579 (2004).
91. Krishnan, V. et al. Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions. Cell 131, 391–404 (2007).
92. Golden, S. A., Covington, H. E., Berton, O. & Russo, S. J. A standardized protocol for repeated social defeat stress in mice. Nat. Protoc. 6, 1183–1191 (2011).
93. Sachs, B. D., Ni, J. R. & Caron, M. G. Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress. Proc. Natl. Acad. Sci. U. S. A. 112, 2557–2562 (2015).
94. Berton, O. et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 311, 864–868 (2006).
95. Challis, C. et al. Raphe GABAergic Neurons Mediate the Acquisition of Avoidance after Social Defeat. J. Neurosci. 33, 13978–13988 (2013).
96. Zou, W. J. et al. A discrete serotonergic circuit regulates vulnerability to social stress. Nat. Commun. 11, 1–13 (2020).
97. Fanselow, M. S. & Dong, H. W. Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures? Neuron 65, 7–19 (2010).
98. O’Reilly, R. C. & McClelland, J. L. Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade‐off. Hippocampus 4, 661–682 (1994).
99. Dale, E. et al. Effects of serotonin in the hippocampus: How SSRIs and multimodal antidepressants might regulate pyramidal cell function. CNS Spectr. 21, 143–161 (2016).
100. Bower, G. H. Commentary on mood and memory. Behav. Res. Ther. 25, 443–55 (1987).
101. Gotlib, I. H. et al. Coherence and specificity of information-processing biases in depression and social phobia. J. Abnorm. Psychol. 113, 386–398 (2004).
102. Hamilton, J. P. & Gotlib, I. H. Neural Substrates of Increased Memory Sensitivity for Negative Stimuli in Major Depression. Biol. Psychiatry 63, 1155–1162 (2008).
103. Koster, E. H. W., De Raedt, R., Leyman, L. & De Lissnyder, E. Mood-congruent attention and memory bias in dysphoria: Exploring the coherence among information-processing biases. Behav. Res. Ther. 48, 219–225 (2010).
104. Gaddy, M. A. & Ingram, R. E. A meta-analytic review of mood-congruent implicit memory in depressed mood. Clin. Psychol. Rev. 34, 402–416 (2014).
105. Seligman, M. E. P. Positive Psychology: A Personal History. Annu. Rev. Clin. Psychol. 15, 1–23 (2019).
106. Fredrickson, B. L. The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. Am. Psychol. 56, 218–26 (2001).
107. Sin, N. L. & Lyubomirsky, S. Enhancing well-being and alleviating depressive symptoms with positive psychology interventions: a practice-friendly meta-analysis. J. Clin. Psychol. 65, 467–87 (2009).
108. Wong, P. T. P. Existential positive psychology and integrative meaning therapy. Int. Rev. Psychiatry 32, 565–578 (2020).
109. Frankland, P. W., Josselyn, S. A. & Köhler, S. The neurobiological foundation of memory retrieval. Nat. Neurosci. 22, 1576–1585 (2019).
110. Josselyn, S. A. & Tonegawa, S. Memory engrams: Recalling the past and imagining the future. Science. 367, (2020).
111. Schacter, D. L., Eich, J. E. & Tulving, E. Richard Semon’s theory of memory. J. Verbal Learning Verbal Behav. 17, 721–743 (1978).
112. Liu, X. et al. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 484, 381–385 (2012).
113. Ramirez, S. et al. Creating a false memory in the hippocampus. Science. 341, 387–91 (2013).
114. Redondo, R. L. et al. Bidirectional switch of the valence associated with a hippocampal contextual memory engram. Nature 513, 426–430 (2014).
115. Roy, D. S. et al. Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease. Nature 531, 508–512 (2016).
116. Roy, D. S., Muralidhar, S., Smith, L. M. & Tonegawa, S. Silent memory engrams as the basis for retrograde amnesia. Proc. Natl. Acad. Sci. U. S. A. 114, E9972–E9979 (2017).
117. Chen, B. K. et al. Artificially Enhancing and Suppressing Hippocampus-Mediated Memories. Curr. Biol. 29, 1885-1894.e4 (2019).
118. Zhang, T. R. et al. Negative memory engrams in the hippocampus enhance the susceptibility to chronic social defeat stress. J. Neurosci. 39, 7576–7590 (2019).
119. Doucette, E. et al. Social behavior in mice following chronic optogenetic stimulation of hippocampal engrams. Neurobiol. Learn. Mem. 176, (2020).
120. Ramirez, S. et al. Activating positive memory engrams suppresses depression-like behaviour. Nature 522, 335–339 (2015).
121. Ye, L. et al. Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences. Cell 165, 1776–1788 (2016).
122. Guenthner, C. J., Miyamichi, K., Yang, H. H., Heller, H. C. & Luo, L. Permanent genetic access to transiently active neurons via TRAP: Targeted recombination in active populations. Neuron 78, 773–784 (2013).
123. Denny, C. A. et al. Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron 83, 189–201 (2014).
124. Kirihara, Y., Takechi, M., Kurosaki, K., Kobayashi, Y. & Kurosawa, T. Anesthetic effects of a mixture of medetomidine, midazolam and butorphanol in two strains of mice. Exp. Anim. 62, 173–80 (2013).
125. Andoh, C. et al. TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility. Brain Res. 1704, 68–77 (2019).
126. Matsuda, T. & Cepko, C. L. Controlled expression of transgenes introduced by in vivo electroporation. Proc. Natl. Acad. Sci. U. S. A. 104, 1027–1032 (2007).
127. Kaufling, J. Alterations and adaptation of ventral tegmental area dopaminergic neurons in animal models of depression. Cell Tissue Res. 59–71 (2019) doi:10.1007/s00441-019-03007-9
128. Douma, E. H. & de Kloet, E. R. Stress-induced plasticity and functioning of ventral tegmental dopamine neurons. Neurosci. Biobehav. Rev. 108, 48–77 (2020).
129. Wittmann, B. C. et al. Reward-related fMRI activation of dopaminergic midbrain is associated with enhanced hippocampus-dependent long-term memory formation. Neuron 45, 459–467 (2005).
130. Russo, S. J. & Nestler, E. J. The brain reward circuitry in mood disorders. Nat. Rev. Neurosci. 14, 609–625 (2013).
131. Castillo Díaz, F., Caffino, L. & Fumagalli, F. Bidirectional role of dopamine in learning and memory-active forgetting. Neurosci. Biobehav. Rev. 131, 953–963 (2021).
132. Chaudhury, D. et al. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 493, 532–536 (2013).
133. Tye, K. M. et al. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 493, 537–541 (2013).
134. Friedman, A. K. et al. Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science. 344, 313–9 (2014).
135. Wook Koo, J. et al. Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors. Biol. Psychiatry 80, 469–478 (2016).
136. Steru, L., Chermat, R., Thierry, B. & Simon, P. The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl). 85, 367–370 (1985).
137. Walsh, J. J. et al. 5-HT release in nucleus accumbens rescues social deficits in mouse autism model. Nature (2018). doi:10.1038/s41586-018-0416-4
138. Dölen, G., Darvishzadeh, A., Huang, K. W. & Malenka, R. C. Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature 501, 179–184 (2013).
139. Marcinkiewcz, C. A. et al. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature 537, 97–101 (2016).
140. Mosienko, V. et al. Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Transl. Psychiatry 2, e122-9 (2012).
141. Takahashi, A., Shimamoto, A., Boyson, C. O., DeBold, J. F. & Miczek, K. A. GABAB receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in mice. J. Neurosci. 30, 11771–11780 (2010).
142. Stanton, C. H., Holmes, A. J., Chang, S. W. C. & Joormann, J. From Stress to Anhedonia: Molecular Processes through Functional Circuits. Trends Neurosci. 42, 23–42 (2019).
143. Nagai, Y. et al. The role of dorsal raphe serotonin neurons in the balance between reward and aversion. Int. J. Mol. Sci. 21, 1–17 (2020).
144. Nazzi, S., Maddaloni, G., Pratelli, M. & Pasqualetti, M. Fluoxetine Induces Morphological Rearrangements of Serotonergic Fibers in the Hippocampus. ACS Chem. Neurosci. 10, 3218–3224 (2019).
145. Medrihan, L. et al. Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron 95, 564-576.e4 (2017).
146. Felsenberg, J. et al. Integration of Parallel Opposing Memories Underlies Memory Extinction. Cell 175, 709-722.e15 (2018).
147. Zhang, X., Kim, J. & Tonegawa, S. Amygdala Reward Neurons Form and Store Fear Extinction Memory. Neuron 105, 1077-1093.e7 (2020).
148. Kitamura, T. et al. Engrams and circuits crucial for systems consolidation of a memory. Science. 356, 73–78 (2017).
149. DeNardo, L. A. et al. Temporal evolution of cortical ensembles promoting remote memory retrieval. Nat. Neurosci. 22, 460–469 (2019).
150. Sengupta, A. & Holmes, A. A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory. Neuron 1–17 (2019). doi:10.1016/j.neuron.2019.05.029
151. Knowland, D. et al. Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression. Cell 170, 284-297.e18 (2017).
152. Zhou, W. et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nat. Neurosci. 22, (2019).
論文の公開元へ
