Prognostic factors for bone metastases from head and neck squamous cell carcinoma: A case series of 97 patients

概要

〔目的(Purpose)〕
Although bone is the second-most frequent site of distant metastases of head and neck squamous cell carcinomas, variable prognostic factors in patients with bone metastases from head and neck squamous cell carcinomas have not been fully investigated. This study aimed to assess the prognostic factors affecting overall survival in these patients. The medical records of 97 patients at two institutions who developed bone metastases from head and neck squamous cell carcinoma between January 2010 and December 2019 were retrospectively reviewed.

〔方法ならびに成績(Methods/Results>〕
A multivariate analysis using a Cox proportional hazards model was performed to identify potential clinical predictive factors for longer overall survival. The median overall survival was 7 months, and the 1-and 2-year overall survival rates for all patients were 35. 4% and 19. 2%, respectively. The independent predictive factors for longer overall survival were single bone metastasis, good performance status, and receiving systemic chemotherapy. The median overall survival with each predictor was 10,10, and 10.5 months, respectively. In a selected group of patients with these three factors, the overall survival was 14.5 months.

〔総括(Conclusion)〕
Single bone metastasis, a good performance status, and receiving systemic chemotherapy were independent predictors of longer overall survival but their contributions were limited.