Associating Liver Partition and Portal vein ligation for Staged hepatectomy（ALPPS）手術における，門脈塞栓術を凌駕する迅速な肝再生現象の原因は明らかでない．我々は，ラット門脈結紮（PVL）モデルとALPPSモデル，ならびにALPPSモデルの虚血肝領域を切除する肝切除モデル（Hx）を確立して，それぞれの手術の動門脈血流動態の差とeNOSの関連に着目し，ALPPSの肝再生促進にeNOS活性化が関与していることを明らかにした．
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