[1] S.H. Orkin, L.I. Zon, Hematopoiesis: an evolving paradigm for stem cell biology, Cell 132 (2008) [631]e[644], https://doi.org/10.1016/j.cell.2008.01.025. S0092-8674(08)00125-6 [pii].
[2] W.M. Yu, X. Liu, J. Shen, O. Jovanovic, E.E. Pohl, S.L. Gerson, T. Finkel, H.E. Broxmeyer, C.K. Qu, Metabolic regulation by the mitochondrial phos- phatase PTPMT1 is required for hematopoietic stem cell differentiation, Cell Stem Cell 12 (2013) 62e74, https://doi.org/10.1016/j.stem.2012.11.022.
[3] M. Maryanovich, Y. Zaltsman, A. Ruggiero, A. Goldman, L. Shachnai, S.L. Zaidman, Z. Porat, K. Golan, T. Lapidot, A. Gross, An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate, Nat. Commun. 6 (2015) 7901, https://doi.org/10.1038/ncomms8901.
[4] N.S. Chandel, H. Jasper, T.T. Ho, E. Passegue´, Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing, Nat. Cell Biol. 18 (2016) 823e832, https://doi.org/10.1038/ncb3385.
[5] D. Karigane, H. Kobayashi, T. Morikawa, Y. Ootomo, M. Sakai, G. Nagamatsu, Y. Kubota, N. Goda, M. Matsumoto, E.K. Nishimura, T. Soga, K. Otsu, M. Suematsu, S. Okamoto, T. Suda, K. Takubo, p38a activates purine meta- bolism to initiate hematopoietic stem/progenitor cell cycling in response to stress, Cell Stem Cell 19 (2016) 192e204, https://doi.org/10.1016/j.stem.2016.05.013.
[6] T. Schirmer, P.R. Evans, Structural basis of the allosteric behaviour of phos- phofructokinase, Nature 343 (1990) 140e145, https://doi.org/10.1038/ 343140a0.
[7] R.M. Denton, P.J. Randle, B.J. Bridges, R.H. Cooper, A.L. Kerbey, H.T. Pask, D.L. Severson, D. Stansbie, S. Whitehouse, Regulation of mammalian pyruvate dehydrogenase, Mol. Cell. Biochem. 9 (1975) 27e53.
[8] R.A. Harris, J.W. Hawes, K.M. Popov, Y. Zhao, Y. Shimomura, J. Sato, J. Jaskiewicz, T.D. Hurley, Studies on the regulation of the mitochondrial alpha-ketoacid dehydrogenase complexes and their kinases, Adv. Enzym. Regul. 37 (1997) 271e293.
[9] M.J. Kiel, O.H. Yilmaz, T. Iwashita, C. Terhorst, S.J. Morrison, SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells, Cell 121 (2005) 1109e1121, https://doi.org/ 10.1016/j.cell.2005.05.026. S0092-8674(05)00540-4 [pii].
[10] M. Kondo, I.L. Weissman, K. Akashi, Identification of clonogenic common lymphoid progenitors in mouse bone marrow, Cell 91 (1997) 661e672.
[11] K. Akashi, D. Traver, T. Miyamoto, I.L. Weissman, A clonogenic common myeloid progenitor that gives rise to all myeloid lineages, Nature 404 (2000) 193e197, https://doi.org/10.1038/35004599.
[12] H. Kobayashi, T. Morikawa, A. Okinaga, F. Hamano, T. Hashidate-Yoshida, S. Watanuki, D. Hishikawa, H. Shindou, F. Arai, Y. Kabe, M. Suematsu, T. Shimizu, K. Takubo, Environmental optimization enables maintenance of quiescent hematopoietic stem cells Ex Vivo, BioRxiv (2018) 475905, https:// doi.org/10.1101/475905.
[13] S. Comazzetto, M.M. Murphy, S. Berto, E. Jeffery, Z. Zhao, S.J. Morrison, Restricted hematopoietic progenitors and erythropoiesis require SCF from leptin Receptor+ niche cells in the bone marrow, Cell Stem Cell 24 (2019) 477e486, https://doi.org/10.1016/j.stem.2018.11.022, e476.
[14] K. Takubo, G. Nagamatsu, C.I. Kobayashi, A. Nakamura-Ishizu, H. Kobayashi, E. Ikeda, N. Goda, Y. Rahimi, R.S. Johnson, T. Soga, A. Hirao, M. Suematsu, T. Suda, Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells, Cell Stem Cell 12 (2013) 49e61, https://doi.org/10.1016/j.stem.2012.10.011.
[15] K. Takubo, N. Goda, W. Yamada, H. Iriuchishima, E. Ikeda, Y. Kubota, H. Shima, R.S. Johnson, A. Hirao, M. Suematsu, T. Suda, Regulation of the HIF-1 alpha level is essential for hematopoietic stem cells, Cell Stem Cell 7 (2010) [391]e[402], https://doi.org/10.1016/j.stem.2010.06.020. S1934-5909(10)00344-9 [pii].
[16] F. Buttgereit, M.D. Brand, A hierarchy of ATP-consuming processes in mammalian cells, Biochem. J. 312 (Pt 1) (1995) 163e167.
[17] I. Beerman, J. Seita, M.A. Inlay, I.L. Weissman, D.J. Rossi, Quiescent hemato- poietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle, Cell Stem Cell 15 (2014) 37e50, https://doi.org/10.1016/ j.stem.2014.04.016.
[18] M. Nakano, H. Imamura, T. Nagai, H. Noji, Ca2+ regulation of mitochondrial ATP synthesis visualized at the single cell level, ACS Chem. Biol. 6 (7) (2011) 709e715, https://doi.org/10.1021/cb100313n.
[19] Y.H. Wang, W.J. Israelsen, D. Lee, V.W. Yu, N.T. Jeanson, C.B. Clish, L.C. Cantley, M.G. Vander Heiden, D.T. Scadden, Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis, Cell 158 (2014) 1309e1323, https://doi.org/10.1016/j.cell.2014.07.048.
[20] L. Oburoglu, S. Tardito, V. Fritz, S.C. de Barros, P. Merida, M. Craveiro, J. Mamede, G. Cretenet, C. Mongellaz, X. An, D. Klysz, J. Touhami, M. Boyer- Clavel, J.L. Battini, V. Dardalhon, V.S. Zimmermann, N. Mohandas, E. Gottlieb, M. Sitbon, S. Kinet, N. Taylor, Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification, Cell Stem Cell 15 (2014) 169e184, https://doi.org/10.1016/j.stem.2014.06.002.
[21] F. Paul, Y.A. Arkin, A. Giladi, D.A. Jaitin, E. Kenigsberg, H.,. Keren-Shaul, E. David, Transcriptional heterogeneity and lineage commitment in myeloid progenitors, Cell 163 (7) (2015) 1663e1677, https://doi.org/10.1016/ j.cell.2015.12.046.