1. Lindemann, B. Receptors and transduction in taste. Nature 413, 219–225 (2001).
2. Tu, Y. H. et al. An evolutionarily conserved gene family encodes proton-selective ion channels. Science 359, 1047–1050 (2018).
3. Chandrashekar, J., Hoon, M. A., Ryba, N. J. P. & Zuker, C. S. The receptors and cells for mammalian taste. Nature 444, 288–294 (2006).
4. Ninomiya, Y., Tonosaki, K. & Funakoshi, M. Gustatory neural response in the mouse. Brain Res. 244, 370–373 (1982).
5. Yoshida, R. et al. Taste responsiveness of fungiform taste cells with action potentials. J. Neurophysiol. 96, 3088–3095 (2006).
6. Yoshida, R. et al. NaCl responsive taste cells in the mouse fungiform taste buds. Neuroscience 159, 795–803 (2009).
7. Beidler, L. M. & Smallman, R. L. Renewal of cells within taste buds. J. Cell Biol. 27, 263–272 (1965).
8. Farbman, A. I. Renewal of taste bud cells in rat circumvallate papillae. Cell Tissue Kinet. 13, 349–357 (1980).
9. Runge, E. M., Hoshino, N., Biehl, M. J., Ton, S. & Rochlin, M. W. Neurotrophin-4 is more potent than brain-derived neurotrophic factor in promoting, attracting and suppressing geniculate ganglion neurite outgrowth. Dev. Neurosci. 34, 389–401 (2012).
10. Treffy, R. W. et al. Ephrin-B/EphB signaling is required for normal innervation of lingual gustatory papillae. Dev. Neurosci. 38, 124–138 (2016).
11. Lee, H., Macpherson, L. J., Parada, C. A., Zuker, C. S. & Ryba, N. J. P. Rewiring the taste system. Nature 548, 330–333 (2017).
12. Spielman, A. I. & Brand, J. G. Wiring taste receptor cells to the central gustatory system. Oral Dis. 24, 1388–1389 (2018).
13. De Wit, J. & Ghosh, A. Specification of synaptic connectivity by cell surface interactions. Nat. Rev. Neurosci. 17, 22–35 (2016).
14. Takeichi, M. The cadherin superfamily in neuronal connections and interactions. Nat. Rev. Neurosci. 8, 11–20 (2007).
15. Katsunuma, S. et al. Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium. J. Cell Biol. 212, 561–575 (2016).
16. Duan, X., Krishnaswamy, A., De La Huerta, I. & Sanes, J. R. Type II cadherins guide assembly of a direction-selective retinal circuit. Cell 158, 793–807 (2014).
17. Hondoh, A. et al. Distinct expression of cold receptors (TRPM8 and TRPA1) in the rat nodose-petrosal ganglion complex. Brain Res. 1319, 60–69 (2010).
18. Chandrashekar, J. et al. The taste of carbonation. Science 326, 443–445 (2009).
19. Adler, E. et al. A novel family of mammalian taste receptors. Cell 100, 693–702 (2000).
20. Kim, M. R. et al. Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem. Biophys. Res. Commun. 312, 500–506 (2003).
21. Shigemura, N. et al. Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin. Biochem. Biophys. Res. Commun. 367, 356–363 (2008).
22. Kusuhara, Y. et al. Taste responses in mice lacking taste receptor subunit T1R1. J. Physiol. 591, 1967–1985 (2013).
23. Damak, S. et al. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 301, 850–853 (2003).
24. Thu, C. A. et al. Single-cell identity generated by combinatorial homophilic interactions between α, β, and γ protocadherins. Cell 158, 1045–1059 (2014).
25. Kim, S. Y., Yasuda, S., Tanaka, H., Yamagata, K. & Kim, H. Non-clustered protocadherin. Cell Adh. Migr. 5, 97–105 (2011).
26. Kim, S. Y., Chung, H. S., Sun, W. & Kim, H. Spatiotemporal expression pattern of non-clustered protocadherin family members in the developing rat brain. Neuroscience 147, 996–1021 (2007).
27. Lee, W., Cheng, T. W. & Gong, Q. Olfactory sensory neuron-specific and sexually dimorphic expression of protocadherin 20. J. Comp. Neurol. 507, 1076–1086 (2008).
28. Vuckovic, D. et al. Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss. Hum. Mol. Genet. 24, 5655–5664 (2015).
29. Kusakabe, Y. et al. The neural differentiation gene Mash-1 has a distinct pattern of expression from the taste reception-related genes gustducin and T1R2 in the taste buds. Chem. Senses 27, 445–451 (2002).
30. Shigemura, N. et al. Expression of amiloride-sensitive epithelial sodium channels in mouse taste cells after chorda tympani nerve crush. Chem. Senses 30, 531–538 (2005).
31. Yasumatsu, K., Kusuhara, Y., Shigemura, N. & Ninomiya, Y. Recovery of two independent sweet taste systems during regeneration of the mouse chorda tympani nerve after nerve crush. Eur. J. Neurosci. 26, 1521–1529 (2007).
32. Zhang, J. et al. Sour sensing from the tongue to the brain. Cell 179, 392–402.e15 (2019).
33. Damak, S., Mosinger, B. & Margolskee, R. F. Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice. BMC Neurosci. 9, 96, https://doi.org/10.1186/1471-2202-9-96 (2008).
34. Shigemura, N. et al. Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures. Endocrinology 145, 839–847 (2004).
35. Shigemura, N. et al. Angiotensin II modulates salty and sweet taste sensitivities. J. Neurosci. 33, 6267–6277 (2013).
36. Shigemura, N. et al. Expression of renin-angiotensin system components in the taste organ of mice. Nutrients, 11, https://doi. org/10.3390/nu11092251 (2019).
37. Shigemura, N., Miura, H., Kusakabe, Y., Hino, A. & Ninomiya, Y. Expression of leptin receptor (Ob-R) isoforms and signal transducers and activators of transcription (STATs) mRNAs in the mouse taste buds. Arch. Histol. Cytol. 66, 253–260 (2003).
38. Shigemura, N. et al. Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice. Am. J. Physiol. Integr. Comp. Physiol. 294, R66–R75 (2008).