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Acknowledgements
We appreciate the technical assistance from The Research Support Center, Research Center for Human Disease
Modeling, Kyushu University Graduate School of Medical Sciences. We thank OxMedComms (http://www.
oxmedcomms.com) for proofreading the manuscript.
Author contributions
Conceptualization, A.O., S.I. and N.S.; methodology, A.O., S.I., Y.K., S.T., K.S. and N.S.; validation, A.O., S.I.,
A.H., Y.K., S.T., K.S., N.W. and N.S.; formal analysis, A.O., S.I. and N.S.; investigation, A.O. and S.I.; resources,
S.I. and N.S.; data curation, A.O., S.I. and N.S.; writing—original draft preparation, A.O., S.I. and N.S.; writing—review and editing, A.O., S.I. and N.S.; visualization, A.O., S.I., A.H., Y.O., Y.N., Y.K., S.T., K.S. and N.S.;
supervision, S.I. and N.S.; project administration, N.W. and N.S.; funding acquisition, A.O., S.I. and N.S. All
authors have read and agreed to the published version of the manuscript.
Funding
This work was supported by JSPS KAKENHI grants (JP18K17016, JP19H03818, JP20K18458, JP21H05006,
JP22K09905 and JP22K19672) and JST SPRING grants (JPMJSP2136). The funders had no role in the study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests The authors declare no competing interests.
Additional information
Supplementary Information The online version contains supplementary material available at https://doi.org/
10.1038/s41598-022-25755-5.
Correspondence and requests for materials should be addressed to N.S.
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