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大学・研究所にある論文を検索できる 「マウスの抗がん剤による味覚機能障害の重症度は氷水を用いた経口冷却療法により軽減される」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

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マウスの抗がん剤による味覚機能障害の重症度は氷水を用いた経口冷却療法により軽減される

尾崎, 礼奈 OSAKI, Ayana オサキ, アヤナ 九州大学

2021.03.24

概要

味覚障害は、栄養状態を悪化させ、生活の質を低下させ得るがん化学療法の一般的な副作用の一つである。しかしながら、化学療法誘発性味覚障害の根底にある分子メカニズムはほとんど不明のままである。さらに、化学療法誘発性味覚障害に対する効果的な予防策はない。本研究では、頭頸部がん治療において一般的に用いられる3つの抗がん剤(TPF:ドセタキセル、シスプラチン、5-フルオロウラシル)がマウスの味覚組織の構造と機能に及ぼす影響を調査し、TPF投与後に氷水を飲むとこれらの影響が軽減されるかどうかを調べた。その結果、TPF投与により、舌の有郭乳頭味蕾においてアポトーシスおよび増殖マーカーを発現する細胞の数が有意に増加した。また、甘味・うま味・苦味を伝えるⅡ型味細胞のマーカータンパク質であるガストデューシンやPLCβ2、甘味・うま味を伝えるⅡ型味細胞マーカータンパク質であるT1R3、および酸味を伝えるⅢ型味細胞マーカータンパク質であるCaⅣを発現する味細胞の数が有意に減少した。さらに、味溶液に対する舌咽神経応答の大きさが有意に減少した。上記の結果は、抗がん剤による味覚機能障害は、味覚関連分子を発現する味細胞数の減少により生じる可能性があることが示唆された。加えて、これらの味細胞マーカーの発現と味覚神経応答に対するTPFの影響は、氷水を飲むことによって軽減された。以上により、氷水を用いた経口冷却療法は、ヒトの化学療法誘発性味覚障害の予防に役立つ可能性があることが示唆された。

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