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DAAs治療によるHCV排除が肝病変及び肝外病変に与える影響についての検討

得地, 祐匡 北海道大学

2023.03.23

概要

【背景と目的】
直接作用型抗ウイルス薬(Direct acting antivirals, DAAs)は、合併症のな
い C 型肝炎ウイルス(Hepatitis C virus, HCV)感染患者だけでなく、併存疾
患を有する患者においても安全かつ高率に HCV を排除できる事が報告さ
れている。しかし DAAs 治療による HCV 排除が、併存疾患にどのような影
響を及ぼすかは十分に検討されていない。HCV 感染は、腎機能障害の原因
となり得るため、DAAs 治療による HCV 排除によって腎機能の改善が期待
されるが、最近の研究で DAAs 治療による HCV 排除後に推定糸球体濾過量
(estimated Glomerular filtration rate, eGFR)の低下を認めた事が報告され
た。一方、慢性肝疾患患者では骨格筋量低下に伴う血清クレアチニン濃度の
低下により腎機能の過大評価が頻繁に起こる事が報告されている。また、低
骨格筋量患者で DAAs 治療後に骨格筋量増加を認めた事が報告され、DAAs
治療後の骨格筋量増加が eGFR に影響を与えた可能性が考えられた。そこ
で第一章では、DAAs 治療による HCV 排除が腎機能に及ぼす真の影響を明
らかにする事を目的とした。
さらに、DAAs 治療後の骨格筋量変化のメカニズムについては明らかにさ
れていないため、第二章では DAAs 治療前後の骨格筋量変化と関連した因
子について検討した。
また、HCV 感染は肝脂肪化を引き起こす事が示唆されており、HCV 排除は
肝脂肪化の改善に寄与する可能性がある。一方で HCV 排除は、肝臓のコレ
ステロール分泌を促進し、脂質異常症を引き起こす事が危惧される。HCV
排除後の脂肪肝の存在は肝発癌、線維化進行との関連が報告されているが、
HCV 排除後の脂肪肝、脂質異常症の長期的な変化や関連については十分に
明らかにされていない。第三章では DAAs 治療による HCV 排除が肝脂肪化
及び脂質異常症に与える影響を検討した。
【対象と方法】
(第一章)
2014 年 10 月から 2018 年 4 月の間に当院で DAAs 治療を受けた HCV 感
染患者で、治療開始時及び投与終了後 48 週目(以降、Sustained virological
response 48:SVR48)に臨床情報と保存血清を有する 207 例を対象とした。 ...

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参考文献

Assy, N., Hochberg, Z., Amit, T., Shen-Orr, Z., Enat, R., and Baruch, Y.

(1997). Growth hormone-stimulated insulin-like growth factor (IGF) I

and IGF-binding protein-3 in liver cirrhosis. J. Hepatol. 27 , 796-802.

Beste, L.A., Green, P.K., Berry, K., Kogut, M.J., Allison, S.K., and

Ioannou, G.N. (2017). Effectiveness of hepatitis C antiviral treatment in

a USA cohort of veteran patients with hepatocellular carcinoma. J.

Hepatol. 67 , 32-39.

Børsheim, E., Bui, Q.U., Tissier, S., Kobayashi, H., Ferrando, A.A., and

Wolfe, R.R. (2008). Effect of amino acid supplementation on muscle mass,

strength and physical function in elderly. Clin. Nutr. 27, 189-195.

Brass, E.P. (2000). Supplemental carnitine and exercise. Am. J. Clin.

Nutr. 72 , 618s-623s.

Cacoub, P., Desbois, A.C., Isnard-Bagnis, C., Rocatello, D., and Ferri, C.

(2016). Hepatitis C virus infection and chronic kidney disease: Time for

reappraisal. J. Hepatol. 65 , s82-s94.

Ceglia, L., da Silva Morais, M., Park, L.K., Morris, E., Harris, S.S.,

Bischoff-Ferrari, H.A., Fielding, R.A., and Dawson-Hughes, B. (2010).

Multi-step immunofluorescent analysis of vitamin D receptor loci and

myosin heavy chain isoforms in human skeletal muscle. J. Mol. Histol.

41 , 137-142.

Cheng, Y., Dharancy, S., Malapel, M., and Desreumaux, P. (2005).

Hepatitis C virus infection down-regulates the expression of peroxisome

proliferator-activated receptor alpha and carnitine palmitoyl acyl-CoA

transferase 1A. World J. Gastroenterol. 11, 7591-7596.

Chiu, S.M., Tsai, M.C., Lin, C.Y., Chen, C.H., Lu, S.N., Hung, C.H., Sheen,

100

I.S., Chien, R.N., Lin, C.L., Hu, T.H., et al. (2020). Serial changes of renal

function after directly acting antivirals treatment for chronic hepatitis

C: A 1-year follow-up study after treatment. PLoS One 15, e0231102.

Cruz-Jentoft, A.J., Baeyens, J.P., Bauer, J.M., Boirie, Y., Cederholm, T.,

Landi, F., Martin, F.C., Michel, J.P., Rolland, Y., Schneider, S.M., et al.

(2010). Sarcopenia: European consensus on definition and diagnosis:

Report of the European Working Group on Sarcopenia in Older People.

Age Ageing 39, 412-423.

Czaja, A.J., Carpenter, H.A., Santrach, P.J., and Moore, S.B. (1998).

Host- and disease-specific factors affecting steatosis in chronic hepatitis

C. J. Hepatol. 29 , 198-206.

Dasarathy, S. (2012). Consilience in sarcopenia of cirrhosis. J Cachexia

Sarcopenia Muscle 3 , 225-237.

Donaghy, A.J., Delhanty, P.J., Ho, K.K., Williams, R., and Baxter, R.C.

(2002). Regulation of the growth hormone receptor/binding protein,

insulin-like growth factor ternary complex system in human cirrhosis. J.

Hepatol. 36 , 751-758.

Fabrizi, F., Plaisier, E., Saadoun, D., Martin, P., Messa, P., and Cacoub,

P. (2013). Hepatitis C virus infection, mixed cryoglobulinemia, and

kidney disease. Am. J. Kidney Dis. 61, 623-637.

Fioravante, M., Alegre, S.M., Marin, D.M., Lorena, S.L., Pereira, T.S.,

and Soares, E.C. (2012). Weight loss and resting energy expenditure in

patients with chronic hepatitis C before and during standard treatment.

Nutrition 28 , 630-634.

Flanagan, J.L., Simmons, P.A., Vehige, J., Willcox, M.D., and Garrett, Q.

(2010). Role of carnitine in disease. Nutr. Metab. (Lond.) 7 , 30.

Fouad, Y., Lazarus, J.V., Negro, F., Peck-Radosavljevic, M., Sarin, S.K.,

101

Ferenci, P., Esmat, G., Ghazinian, H., Nakajima, A., Silva, M., et al.

(2021). MAFLD considerations as a part of the global hepatitis C

elimination effort: an international perspective. Aliment. Pharmacol.

Ther. 53, 1080-1089.

Francoz, C., and Sola, E. (2019). Assessment of renal function in

cirrhosis: Sarcopenia, gender and ethnicity matter. J. Hepatol. 70 , 828830.

Gnoni, A., Longo, S., Gnoni, G.V., and Giudetti, A.M. (2020). Carnitine in

Human Muscle Bioenergetics: Can Carnitine Supplementation Improve

Physical Exercise? Molecules 25.

Hanai, T., Shiraki, M., Ohnishi, S., Miyazaki, T., Ideta, T., Kochi, T., Imai,

K., Suetsugu, A., Takai, K., Moriwaki, H., and Shimizu, M. (2016). Rapid

skeletal muscle wasting predicts worse survival in patients with liver

cirrhosis. Hepatol. Res. 46 , 743-751.

Hevonoja, T., Pentikäinen, M.O., Hyvönen, M.T., Kovanen, P.T., and Ala Korpela, M. (2000). Structure of low density lipoprotein (LDL) particles:

basis for understanding molecular changes in modified LDL. Biochim.

Biophys. Acta 1488 , 189-210.

Hoogeveen, R.C., Gaubatz, J.W., Sun, W., Dodge, R.C., Crosby, J.R., Jiang,

J., Couper, D., Virani, S.S., Kathiresan, S., Boerwinkle, E., and

Ballantyne, C.M. (2014). Small dense low-density lipoprotein-cholesterol

concentrations

predict

risk

for

coronary

heart

disease:

the

Atherosclerosis Risk In Communities (ARIC) study. Arterioscler. Thromb.

Vasc. Biol. 34 , 1069-1077.

Ichikawa, T., Miyaaki, H., Miuma, S., Motoyoshi, Y., Narita, S., Toda, S.,

Takahashi, Y., Honda, T., Yajima, H., Uehara, R., et al. (2019). Carotid

Intima-media Thickness and Small Dense Low-density Lipoprotein

Cholesterol Increase after One Year of Treatment with Direct-acting

Antivirals in Patients with Hepatitis C Virus Infection. Intern. Med. 58 ,

102

1209-1215.

Iritani, S., Imai, K., Takai, K., Hanai, T., Ideta, T., Miyazaki, T., Suetsugu,

A., Shiraki, M., Shimizu, M., and Moriwaki, H. (2015). Skeletal muscle

depletion is an independent prognostic factor for hepatocellular

carcinoma. J. Gastroenterol. 50 , 323-332.

Ito, T., Ishigami, M., Zou, B., Tanaka, T., Takahashi, H., Kurosaki, M.,

Maeda, M., Thin, K.N., Tanaka, K., Takahashi, Y., et al. (2021). The

epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with

individual and forecasting analysis, 1995-2040. Hepatol. Int. 15 , 366-379.

Izumi, N., Hayashi, N., Kumada, H., Okanoue, T., Tsubouchi, H.,

Yatsuhashi, H., Kato, M., Ki, R., Komada, Y., Seto, C., and Goto, S. (2014).

Once-daily simeprevir with peginterferon and ribavirin for treatmentexperienced

HCV

genotype

1-infected

patients

in

Japan:

the

CONCERTO-2 and CONCERTO-3 studies. J. Gastroenterol. 49 , 941-953.

Ji, D., Chen, G.F., Niu, X.X., Zhang, M., Wang, C., Shao, Q., Wu, V., Wang,

Y., Cheng, G., Hurwitz, S.J., et al. (2021). Non-alcoholic fatty liver

disease is a risk factor for occurrence of hepatocellular carcinoma after

sustained virologic response in chronic hepatitis C patients: A

prospective four-years follow-up study. Metabol Open 10 , 100090.

Karlas, T., Petroff, D., Sasso, M., Fan, J.G., Mi, Y.Q., de Lédinghen, V.,

Kumar, M., Lupsor-Platon, M., Han, K.H., Cardoso, A.C., et al. (2017).

Individual

patient

data

meta-analysis

of

controlled

attenuation

parameter (CAP) technology for assessing steatosis. J. Hepatol. 66, 10221030.

Katsanos, C.S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., and

Wolfe, R.R. (2006). A high proportion of leucine is required for optimal

stimulation of the rate of muscle protein synthesis by essential amino

acids in the elderly. Am. J. Physiol. Endocrinol. Metab. 291 , E381-387.

103

Katsiki, N., Mikhailidis, D.P., and Mantzoros, C.S. (2016). Non-alcoholic

fatty liver disease and dyslipidemia: An update. Metabolism 65, 11091123.

Kawagishi, N., Suda, G., Kimura, M., Maehara, O., Shimazaki, T.,

Yamada, R., Kitagataya, T., Shigesawa, T., Suzuki, K., Nakamura, A., et

al. (2020). High serum angiopoietin-2 level predicts non-regression of

liver stiffness measurement-based liver fibrosis stage after direct-acting

antiviral therapy for hepatitis C. Hepatol. Res. 50, 671-681.

Kawagishi, N., Suda, G., Nakamura, A., Kimura, M., Maehara, O.,

Suzuki, K., Nakamura, A., Ohara, M., Izumi, T., Umemura, M., et al.

(2018). Liver steatosis and dyslipidemia after HCV eradication by direct

acting antiviral agents are synergistic risks of atherosclerosis. PLoS One

13 , e0209615.

Kobayashi, M., Suzuki, F., Fujiyama, S., Kawamura, Y., Sezaki, H.,

Hosaka, T., Akuta, N., Suzuki, Y., Saitoh, S., Arase, Y., et al. (2017).

Sustained virologic response by direct antiviral agents reduces the

incidence of hepatocellular carcinoma in patients with HCV infection. J.

Med. Virol. 89, 476-483.

Koizumi, T., Nikaido, H., Hayakawa, J., Nonomura, A., and Yoneda, T.

(1988). Infantile disease with microvesicular fatty infiltration of viscera

spontaneously occurring in the C3H-H-2(0) strain of mouse with

similarities to Reye's syndrome. Lab. Anim. 22 , 83-87.

Korenaga, M., Wang, T., Li, Y., Showalter, L.A., Chan, T., Sun, J., and

Weinman,

S.A.

(2005).

Hepatitis

virus

core

protein

inhibits

mitochondrial electron transport and increases reactive oxygen species

(ROS) production. J. Biol. Chem. 280 , 37481-37488.

Krishnan, P., Schnell, G., Tripathi, R., Beyer, J., Reisch, T., Dekhtyar, T.,

Irvin, M., Xie, W., Fu, B., Burroughs, M., et al. (2018). Integrated

Resistance Analysis of CERTAIN-1 and CERTAIN-2 Studies in Hepatitis

104

C Virus-Infected Patients Receiving Glecaprevir and Pibrentasvir in

Japan. Antimicrob. Agents Chemother. 62 .

Lavanchy, D. (2011). Evolving epidemiology of hepatitis C virus. Clin.

Microbiol. Infect. 17 , 107-115. 10.1111/j.1469-0691.

Lee, J.J., Lin, M.Y., Chang, J.S., Hung, C.C., Chang, J.M., Chen, H.C.,

Yu, M.L., and Hwang, S.J. (2014). Hepatitis C virus infection increases

risk of developing end-stage renal disease using competing risk analysis.

PLoS One 9 , e100790.

Leslie, J., Geh, D., Elsharkawy, A.M., Mann, D.A., and Vacca, M. (2022).

Metabolic dysfunction and cancer in HCV: Shared pathways and mutual

interactions. J. Hepatol. 77, 219-236.

Lok, A.S., and McMahon, B.J. (2007). Chronic hepatitis B. Hepatology 45,

507-539.

Machado, M.V., Oliveira, A.G., and Cortez-Pinto, H. (2010). Hepatic

steatosis

in

patients

coinfected

with

human

immunodeficiency

virus/hepatitis C virus: a meta-analysis of the risk factors. Hepatology

52 , 71-78. 10.1002/hep.23619.

Magoulas, P.L., and El-Hattab, A.W. (2012). Systemic primary carnitine

deficiency: an overview of clinical manifestations, diagnosis, and

management. Orphanet J. Rare Dis. 7 , 68.

Martin, P., DiMartini, A., Feng, S., Brown, R., Jr., and Fallon, M. (2014).

Evaluation for liver transplantation in adults: 2013 practice guideline by

the American Association for the Study of Liver Diseases and the

American Society of Transplantation. Hepatology 59, 1144-1165.

Masuda, T., Shirabe, K., Ikegami, T., Harimoto, N., Yoshizumi, T.,

Soejima, Y., Uchiyama, H., Ikeda, T., Baba, H., and Maehara, Y. (2014).

Sarcopenia is a prognostic factor in living donor liver transplantation.

Liver Transpl. 20, 401-407.

105

McPherron, A.C., Lawler, A.M., and Lee, S.J. (1997). Regulation of

skeletal muscle mass in mice by a new TGF-beta superfamily member.

Nature 387 , 83-90.

Mettke, F., Schlevogt, B., Deterding, K., Wranke, A., Smith, A., Port, K.,

Manns, M.P., Vogel, A., Cornberg, M., and Wedemeyer, H. (2018).

Interferon-free therapy of chronic hepatitis C with direct-acting

antivirals does not change the short-term risk for de novo hepatocellular

carcinoma in patients with liver cirrhosis. Aliment. Pharmacol. Ther. 47 ,

516-525.

Misiani, R., Bellavita, P., Fenili, D., Vicari, O., Marchesi, D., Sironi, P.L.,

Zilio, P., Vernocchi, A., Massazza, M., Vendramin, G., and et al. (1994).

Interferon alfa-2a therapy in cryoglobulinemia associated with hepatitis

C virus. N. Engl. J. Med. 330 , 751-756.

Mitwalli, A.H., Al-Wakeel, J.S., Alam, A., Tarif, N., Abu-Aisha, H.,

Rashed, M., and Al Nahed, N. (2005). L-carnitine supplementation in

hemodialysis patients. Saudi J. Kidney Dis. Transpl. 16 , 17-22.

Miyanari, Y., Atsuzawa, K., Usuda, N., Watashi, K., Hishiki, T., Zayas,

M., Bartenschlager, R., Wakita, T., Hijikata, M., and Shimotohno, K.

(2007). The lipid droplet is an important organelle for hepatitis C virus

production. Nat. Cell Biol. 9, 1089-1097.

Moriwaki, H., Miwa, Y., Tajika, M., Kato, M., Fukushima, H., and Shiraki,

M. (2004). Branched-chain amino acids as a protein- and energy-source

in liver cirrhosis. Biochem. Biophys. Res. Commun. 313, 405-409.

Nagata, H., Nakagawa, M., Asahina, Y., Sato, A., Asano, Y., Tsunoda, T.,

Miyoshi, M., Kaneko, S., Otani, S., Kawai-Kitahata, F., et al. (2017).

Effect of interferon-based and -free therapy on early occurrence and

recurrence of hepatocellular carcinoma in chronic hepatitis C. J. Hepatol.

67 , 933-939.

106

Nakanishi, H., Kurosaki, M., Tsuchiya, K., Nakakuki, N., Takada, H.,

Matsuda, S., Gondo, K., Asano, Y., Hattori, N., Tamaki, N., et al. (2015).

L-carnitine Reduces Muscle Cramps in Patients With Cirrhosis. Cli n.

Gastroenterol. Hepatol. 13 , 1540-1543.

Nishikawa, H., Shiraki, M., Hiramatsu, A., Moriya, K., Hino, K., and

Nishiguchi, S. (2016). Japan Society of Hepatology guidelines for

sarcopenia in liver disease (1st edition): Recommendation from the

working group for creation of sarcopenia assessment criteria. Hepatol.

Res. 46 , 951-963.

Noureddin, M., Wong, M.M., Todo, T., Lu, S.C., Sanyal, A.J., and Mena,

E.A. (2018). Fatty liver in hepatitis C patients post-sustained virological

response with direct-acting antivirals. World J. Gastroenterol. 24 , 12691277.

Ohara, M., Ogawa, K., Suda, G., Kimura, M., Maehara, O., Shimazaki,

T., Suzuki, K., Nakamura, A., Umemura, M., Izumi, T., et al. (2018). L Carnitine Suppresses Loss of Skeletal Muscle Mass in Patients Wit h

Liver Cirrhosis. Hepatol Commun 2, 906-918.

Ohara, M., Suda, G., Kimura, M., Maehara, O., Shimazaki, T., Shigesawa,

T., Suzuki, K., Nakamura, A., Kawagishi, N., Nakai, M., et al. (2020a).

Analysis of the optimal psoas muscle mass index cut-off values, as

measured by computed tomography, for the diagnosis of loss of skeletal

muscle mass in Japanese people. Hepatol. Res. 50, 715-725.

Ohara, M., Suda, G., Kimura, M., Maehara, O., Shimazaki, T., Shigesawa,

T., Suzuki, K., Nakamura, A., Kawagishi, N., Nakai, M., et al. (2020b).

Computed tomography, not bioelectrical impedance analysis, is the

proper method for evaluating changes in skeletal muscle mass in liver

disease. JCSM Rapid Communications 3 , 103-114.

Perlemuter, G., Sabile, A., Letteron, P., Vona, G., Topilco, A., Chrétien, Y.,

107

Koike, K., Pessayre, D., Chapman, J., Barba, G., and Bréchot, C. (2002).

Hepatitis C virus core protein inhibits microsomal triglyceride transfer

protein activity and very low density lipoprotein secretion: a model of

viral-related steatosis. FASEB J. 16, 185-194.

Poynard, T., Ratziu, V., McHutchison, J., Manns, M., Goodman, Z.,

Zeuzem, S., Younossi, Z., and Albrecht, J. (2003). Effect of treatment with

peginterferon or interferon alfa-2b and ribavirin on steatosis in patients

infected with hepatitis C. Hepatology 38 , 75-85.

Price, J.C., Ma, Y., Scherzer, R., Korn, N., Tillinghast, K., Peters, M.G.,

Noworolski, S.M., and Tien, P.C. (2017). Human immunodeficiency virusinfected and uninfected adults with non-genotype 3 hepatitis C virus

have less hepatic steatosis than adults with neither infection. Hepatology

65 , 853-863.

Rawlings, N.D., and Barrett, A.J. (1990). Evolution of proteins of the

cystatin superfamily. J. Mol. Evol. 30 , 60-71.

Reig, M., Mariño, Z., Perelló, C., Iñarrairaegui, M., Ribeiro, A., Lens, S.,

Díaz, A., Vilana, R., Darnell, A., Varela, M., et al. (2016). Unexpected

high rate of early tumor recurrence in patients with HCV-related HCC

undergoing interferon-free therapy. J. Hepatol. 65 , 719-726.

Reuter, S.E., and Evans, A.M. (2012). Carnitine and acylcarnitines:

pharmacokinetic,

pharmacological

and

clinical

aspects.

Clin.

Pharmacokinet. 51 , 553-572.

Ridker, P.M., Danielson, E., Fonseca, F.A., Genest, J., Gotto, A.M., Jr. ,

Kastelein, J.J., Koenig, W., Libby, P., Lorenzatti, A.J., MacFadyen, J.G.,

et al. (2008). Rosuvastatin to prevent vascular events in men and women

with elevated C-reactive protein. N. Engl. J. Med. 359 , 2195-2207.

Roguljic, H., Nincevic, V., Bojanic, K., Kuna, L., Smolic, R., Vcev, A.,

Primorac, D., Vceva, A., Wu, G.Y., and Smolic, M. (2021). Impact of DAA

108

Treatment on Cardiovascular Disease Risk in Chronic HCV Infection: An

Update. Front. Pharmacol. 12 , 678546.

Rubbia-Brandt, L., Quadri, R., Abid, K., Giostra, E., Malé, P.J., Mentha,

G., Spahr, L., Zarski, J.P., Borisch, B., Hadengue, A., and Negro, F. (2000).

Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype

3. J. Hepatol. 33, 106-115.

Rudman, D., Sewell, C.W., and Ansley, J.D. (1977). Deficiency of carnitine

in cachectic cirrhotic patients. J. Clin. Invest. 60, 716-723.

Sakamoto, N., and Watanabe, M. (2009). New therapeutic approaches to

hepatitis C virus. J. Gastroenterol. 44, 643-649.

Schmidt-Arras, D., and Rose-John, S. (2016). IL-6 pathway in the liver:

From physiopathology to therapy. J. Hepatol. 64, 1403-1415.

Silvério, R., Laviano, A., Rossi Fanelli, F., and Seelaender, M. (2011). l carnitine and cancer cachexia: Clinical and experimental aspects. J

Cachexia Sarcopenia Muscle 2, 37-44.

Suda, G., Hasebe, C., Abe, M., Kurosaki, M., Itakura, J., Izumi, N.,

Uchida, Y., Mochida, S., Haga, H., Ueno, Y., et al. (2019a). Safety and

efficacy of glecaprevir and pibrentasvir in Japanese hemodialysis

patients with genotype 2 hepatitis C virus infection. J. Gastroenterol. 54 ,

641-649.

Suda, G., Nakai, M., Sho, T., Kimura, M., Shimazaki, T., Maehara, O.,

Shigesawa, T., Suzuki, K., Nakamura, A., Ohara, M., et al. (2019b). The

Successful Retreatment with Glecaprevir and Pibrentasvir of Genotype 1

or 2 HCV-infected Hemodialysis Patients who Failed to Respond to NS5A

and Protease Inhibitor Treatment. Intern. Med. 58 , 943-947.

Suda, G., Ogawa, K., Morikawa, K., and Sakamoto, N. (2018). Treatment

of hepatitis C in special populations. J. Gastroenterol. 53, 591-605.

109

Suda, G., and Sakamoto, N. (2021). Recent advances in the treatment of

hepatitis C virus infection for special populations and remaining

problems. J. Gastroenterol. Hepatol. 36, 1152-1158.

Suda, G., Sakamoto, N., Itsui, Y., Nakagawa, M., Tasaka-Fujita, M.,

Funaoka, Y., Watanabe, T., Nitta, S., Kiyohashi, K., Azuma, S., et al.

(2010).

IL-6-mediated

intersubgenotypic

variation

of

interferon

sensitivity in hepatitis C virus genotype 2a/2b chimeric clones. Virology

407 , 80-90.

Sugimoto, R., Iwasa, M., Hara, N., Tamai, Y., Yoshikawa, K., Ogura, S.,

Tanaka, H., Eguchi, A., Yamamoto, N., Kobayashi, Y., et al. (2018).

Changes in liver function and body composition by direct-acting antiviral

therapy for hepatitis C virus infection. Hepatol. Res. 48 , 337-344.

Sun, H.Y., Cheng, P.N., Tseng, C.Y., Tsai, W.J., Chiu, Y.C., and Young,

K.C. (2018). Favouring modulation of circulating lipoproteins and lipid

loading capacity by direct antiviral agents grazoprevir/elbasvir or

ledipasvir/sofosbuvir treatment against chronic HCV infection. Gut 67,

1342-1350.

Syed, G.H., Tang, H., Khan, M., Hassanein, T., Liu, J., and Siddiqui, A.

(2014). Hepatitis C virus stimulates low-density lipoprotein receptor

expression to facilitate viral propagation. J. Virol. 88 , 2519-2529.

Takehara, T., Sakamoto, N., Nishiguchi, S., Ikeda, F., Tatsumi, T., Ueno,

Y., Yatsuhashi, H., Takikawa, Y., Kanda, T., Sakamoto, M., et al. (2019).

Efficacy and safety of sofosbuvir-velpatasvir with or without ribavirin in

HCV-infected Japanese patients with decompensated cirrhosis: an openlabel phase 3 trial. J. Gastroenterol. 54 , 87-95.

Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S.,

Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. (2014). Other types of

primary hyperlipoproteinemia(hyperlipidemia). Executive summary of

110

the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and

prevention of atherosclerotic cardiovascular diseases in Japan--2012

version. J Atheroscler Thromb 21, 82-85.

Tsai, M.C., Lin, C.Y., Hung, C.H., Lu, S.N., Tung, S.Y., Chien, R.N., Lin,

C.L., Wang, J.H., Chien-Hung, C., Chang, K.C., et al. (2019). Evolution

of renal function under direct-acting antivirals treatment for chronic

hepatitis C: A real-world experience. J. Viral Hepat. 26 , 1404-1412.

Tsuge, M., Hiramatsu, A., Shinohara, F., Nakano, N., Nakamura, Y.,

Hatooka, M., Morio, K., Morio, R., Kan, H., Fujino, H., et al. (2016).

Improvement of renal dysfunction in a patient with hepatitis C virus related liver cirrhosis by daclatasvir and asunaprevir combination

therapy: A case report. Hepatol. Res. 46 , 944-948.

Tsukuda, Y., Suda, G., Tsunematsu, S., Ito, J., Sato, F., Terashita, K.,

Nakai, M., Sho, T., Maehara, O., Shimazaki, T., et al. (2017). Anti adipogenic and antiviral effects of l-carnitine on hepatitis C virus

infection. J. Med. Virol. 89, 857-866.

Vallet-Pichard, A., Mallet, V., Nalpas, B., Verkarre, V., Nalpas, A.,

Dhalluin-Venier, V., Fontaine, H., and Pol, S. (2007). FIB-4: an

inexpensive and accurate marker of fibrosis in HCV infection.

comparison with liver biopsy and fibrotest. Hepatology 46, 32-36.

Wiesner, R., Edwards, E., Freeman, R., Harper, A., Kim, R., Kamath, P.,

Kremers, W., Lake, J., Howard, T., Merion, R.M., et al. (2003). Model for

end-stage liver disease (MELD) and allocation of donor livers.

Gastroenterology 124, 91-96.

Yoo, J.J., Kim, S.G., Kim, Y.S., Lee, B., Lee, M.H., Jeong, S.W., Jang, J.Y.,

Lee, S.H., Kim, H.S., Kim, Y.D., and Cheon, G.J. (2019). Estimation of

renal function in patients with liver cirrhosis: Impact of muscle mass and

sex. J. Hepatol. 70 , 847-854.

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