Alstermark B, Kümmel H, Tantisira B. Monosynaptic raphespinal and reticulospinal projection to forelimb motoneurones in cats. Neurosci Lett. 1987. 74(3):286-90.
Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV. Astrocyte scar formation aids central nervous system axon regeneration. Nature. 2016. 532(7598):195-200.
Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG. Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J. Neurotrauma. 2006. 23, 635–659.
Barthélemy D, Grey MJ, Nielsen JB, Bouyer L. Involvement of the corticospinal tract in the control of human gait. Prog Brain Res. 2011. 192:181-97.
Bareyre FM, Kerschensteiner M, Raineteau O, Mettenleiter TC, Weinmann O, Schwab ME. The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats. Nat Neurosci. 2004. 7(3):269-77.
Bellani S, Mescola A, Ronzitti G, Tsushima H, Tilve S, Canale C, Valtorta F, Chieregatti E. GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein. Cell Death Differ. 2014. 21(12):1971-83.
Berger CL, Dong Z, Hanlon D, Bisaccia E, Edelson RL. A Lymphocyte Cell Surface Heat Shock Protein Homologous to the Endoplasmic Reticulum Chaperone, Immunoglobulin Heavy Chain Binding Protein BIP. Int J Cancer. 1997. 71(6):1077-85.
Bradbury EJ, Burnside ER. Moving beyond the glial scar for spinal cord repair. Nat. Commun. 2019. 10(1):3879.
Buffo A, Rolando C, Ceruti S. Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential. Biochem Pharmacol. 2010. 79(2):77-89.
Burikhanov R, Zhao Y, Goswami A, Qiu S, Schwarze SR, Rangnekar VM. The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis. Cell. 2009. 138(2):377-88.
Casaca-Carreira J, Temel Y, Hescham SA, Jahanshahi A. Transependymal Cerebrospinal Fluid Flow: Opportunity for Drug Delivery? Mol. Neurobiol. 2018. 55 (4), 2780–2788.
Casas C. GRP78 at the Centre of the Stage in Cancer and Neuroprotection. Front Neurosci. 2017. 11:177.
Chevilley A, Lesept F, Lenoir S, Ali C, Parcq J, Vivien D. Impacts of tissue-type plasminogen activator (tPA) on neuronal survival. Front Cell Neurosci. 2015. 9:415.
Chiu CG, St-Pierre P, Nabi IR, Wiseman SM. Autocrine Motility Factor Receptor: A Clinical Review. Expert Rev Anticancer Ther. 2008. 8(2):207-17.
Courtine G, Roy RR, Raven J, Hodgson J, McKay H, Yang H, Zhong H, Tuszynski MH, Edgerton VR. Performance of locomotion and foot grasping following a unilateral thoracic corticospinal tract lesion in monkeys (Macaca mulatta). Brain. 2005. 128(Pt 10):2338-58.
Courtine G, Sofroniew MV. Spinal Cord Repair: Advances in Biology and Technology. Nat Med. 2019. 25(6):898-908.
Deng L, Shi B, Zhuang Y, Chu J, Shi X, Zhang S, Guo M. Performance and mechanism of neuroleukin in the growth and survival of sertoli cell-induced neurons in a coculture system. Cell Transplant. 2014. 23(3):381-94.
Dazert S, Kim D, Luo L, Aletsee C, Garfunkel S, Maciag T, Baird A, Ryan AF. Focal delivery of fibroblast growth factor-1 by transfected cells induces spiral ganglion neurite targeting in vitro. J Cell Physiol. 1998. 177(1):123-9.
Decourt B, Bouleau Y, Dulon D, Hafidi A. Expression analysis of neuroleukin, calmodulin, cortactin, and Rho7/Rnd2 in the intact and injured mouse brain. Brain Res Dev Brain Res. 2005. 159(1):36-54.
Diez H, Benitez MJ, Fernandez S, Torres-Aleman I, Garrido JJ, Wandosell F. Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation. Biochim Biophys Acta. 2016. 1863(11):2574-2583.
Dougherty KD, Dreyfus CF, Black IB. Brainderived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury. Neurobiol. Dis. 2000. 7(6 Pt B), 574–585.
Dowell JA, Johnson JA, Li L. Identification of astrocyte secreted proteins with a combination of shotgun proteomics and bioinformatics. J. Proteome Res. 2009. 8, 4135–4143.
Fairbank M, St-Pierre P, Nabi IR. The Complex Biology of Autocrine Motility factor/phosphoglucose Isomerase (AMF/PGI) and Its Receptor, the gp78/AMFR E3 Ubiquitin Ligase. Mol Biosyst. 2009. 5(8):793-801.
Funasaka T, Haga A, Raz A, Nagase H. Tumor autocrine motility factor is an angiogenic factor hat stimulates endothelial cell motility. Biochem. Biophys. Res. Commun. 2001. 284(5) : 1116-25.
Funasaka T, Yanagawa T, Hogan V, Raz A. Regulation of phosphoglucose isomerase/autocrine motility factor expression by hypoxia. FASEB J. 2005. 19(11):1422-30.
Geng H, Xue C, Mendonca J, Sun XX, Liu Q, Reardon PN, Chen Y, Qian K, Hua V, Chen A, Pan F, Yuan J, Dang S, Beer TM, Dai MS, Kachhap SK, Qian DZ. Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy. Nat Commun. 2018. 9(1):4972.
Goldenberg-Cohen N, Raiter A, Gaydar V, Dratviman-Storobinsky O, Goldstein T, Weizman A, Hardy B. Peptide-binding GRP78 protects neurons from hypoxia-induced apoptosis. Apoptosis. 2012 Mar;17(3):278-88.
Gonzalez-Gronow M, Selim MA, Papalas J, Pizzo SV. GRP78: a multifunctional receptor on the cell surface. Antioxid Redox Signal. 2009. 11(9):2299-306.
Gopal U, Gonzalez-Gronow M, Pizzo SV. Activated α2-Macroglobulin Regulates Transcriptional Activation of c-MYC Target Genes through Cell Surface GRP78 Protein. J Biol Chem. 2016. 291(20):10904-15.
Gurney ME, Apatoff BR, Heinrich SP. Suppression of terminal axonal sprouting at the neuromuscular junction by monoclonal antibodies against a muscle-derived antigen of 56,000 daltons. J Cell Biol. 1986a. 102(6):2264-72.
Gurney ME, Heinrich SP, Lee MR, Yin HS. Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons. Science. 1986b. 234, 566–574.
Haga A, Funasaka T, Deyashiki Y, Raz A. Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix met alloproteinase-3 expression via a MAPK pathway. FEBS Lett. 2008. 582(13):1877-82.
Haga A, Tanaka N, Funasaka T, Hashimoto K, Nakamura KT, Watanabe H, Raz A, Nagase H. The autocrine motility factor (AMF) and AMF-receptor combination needs sugar chain recognition ability and interaction using the C-terminal region of AMF. J Mol Biol. 2006. 358 (3): 741-53.
Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, Kijima K, Yoshizaki S, Harimaya K, Nakashima Y, Okada S. Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury. Nat Med. 2017. 23(7):818-828.
Hermann PM, van Kesteren RE, Wildering WC, Painter SD, Reno JM, Smith JS, Kumar SB, Geraerts WP, Ericsson LH, Smit AB, Bulloch AG, Nagle GT. Neurotrophic actions of a novel molluscan epidermal growth factor. J Neurosci. 2000. 20(17):6355-64.
Honda T, Horie M, Daito T, Ikuta K, Tomonaga K. Molecular chaperone BiP interacts with Borna disease virus glycoprotein at the cell surface. J Virol. 2009. 83(23):12622-5.
Huang SP, Chen JC, Wu CC, Chen CT, Tang NY, Ho YT, Lo C, Lin JP, Chung JG, Lin JG. Capsaicin-induced apoptosis in human hepatoma HepG2 cells. Anticancer Res. 2009. 29(1):165-74.
Huang Z, Zhang N, Zha L, Mao HC, Chen X, Xiang JF, Zhang H, Wang ZW. Aberrant Expression of the Autocrine Motility Factor Receptor Correlates with Poor Prognosis and Promotes Metastasis in Gastric Carcinoma. Asian Pac J Cancer Prev. 2014. 15(2):989-97.
Hughes SJ, Antoshchenko T, Chen Y, Lu H, Pizarro JC, Park HW. Probing the ATP Site of GRP78 with Nucleotide Triphosphate Analogs. PLoS One. 2016. 11(5):e0154862.
Hurlbert RJ. Methylprednisolone for Acute Spinal Cord Injury: An Inappropriate Standard of Care. J Neurosurg. 2000. 93(1 Suppl):1-7.
Inada T, Takahashi H, Yamazaki M, Okawa A, Sakuma T, Kato K, Hashimoto M, Hayashi K, Furuya T, Fujiyoshi T, Kawabe J, Mannoji C, Miyashita T, Kadota R, Someya Y, Ikeda O, Hashimoto M, Suda K, Kajino T, Ueda H, Ito Y, Ueta T, Hanaoka H, Takahashi K, Koda M. Multicenter Prospective Nonrandomized Controlled Clinical Trial to Prove Neurotherapeutic Effects of Granulocyte Colony-Stimulating Factor for Acute Spinal Cord Injury. Spine (Phila Pa 1976). 2014. 39(3):213-9.
Ito S, Nagoshi N, Tsuji O, Shibata S, Shinozaki M, Kawabata S, Kojima K, Yasutake K, Hirokawa T, Matsumoto M, Takei K, Nakamura M, Okano H. LOTUS Inhibits Neuronal Apoptosis and Promotes Tract Regeneration in Contusive Spinal Cord Injury Model Mice. eNeuro. 2018. 5(5):ENEURO.0303-18.2018.
Karimi-Abdolrezaee S, Billakanti R. Reactive astrogliosis after spinal cord injury-beneficial and detrimental effects. Mol. Neurobiol. 2012. 46, 251 - 264.
Karve IP, Taylor JM, Crack PJ. The contribution of astrocytes and microglia to traumatic brain injury. Br. J. Pharmacol. 2016. 173, 692 - 702.
Kelber JA, Panopoulos AD, Shani G, Booker EC, Belmonte JC, Vale WW, Gray PC. Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways. Oncogene. 2009. 28(24): 2324-36.
Kern J, Untergasser G, Zenzmaier C, Sarg B, Guenther Gastl, Eberhard Gunsilius, Michael Steurer. GRP-78 Secreted by Tumor Cells Blocks the Antiangiogenic Activity of Bortezomib. Blood. 2009. 114(18):3960-7.
Kho DH, Nangia-Makker P, Balan V, Hogan V, Tait L, Wang Y, Raz A. Autocrine motility factor promotes HER2 cleavage and signaling in breast cancer cells. Cancer Res. 2013. 73(4):1411-9.
Kho DH, Zhang T, Balan V, Wang Y, Ha SW, Xie Y, Raz A. Autocrine motility factor modulates EGF-mediated invasion signaling. Cancer Res. 2014. 74(8):2229-37.
Kodani A, Kikuchi T, Tohda C. Acteoside improves muscle atrophy and motor function by inducing new myokine secretion in chronic spinal cord injury. J Neurotrauma. 2019. 36(12):1935-1948.
Kojic LD, Joshi B, Lajoie P, Le PU, Cox ME, Turbin DA, Wiseman SM, Nabi IR. Raft-dependent endocytosis of autocrine motility factor is phosphatidylinositol 3-kinase-dependent in breast carcinoma cells. J Biol Chem. 2007. 282(40):29305-13.
Kojic LD, Wiseman SM, Ghaidi F, Joshi B, Nedev H, Saragovi HU, Nabi IR. Raft-dependent Endocytosis of Autocrine Motility factor/phosphoglucose Isomerase: A Potential Drug Delivery Route for Tumor Cells. PLoS One. 2008. 3(10):e3597.
Krenz NR, Weaver LC. Nerve growth factor in glia and inflammatory cells of the injured rat spinal cord. J. Neurochem. 2000. 74, 730–739.
Krüttgen A, Möller JC, Heymach JV Jr, Shooter EM. Neurotrophins induce release of neurotrophins by the regulated secretory pathway. Proc Natl Acad Sci U S A. 1998. 95(16):9614-9.
Kuboyama T, Wahane S, Huang Y, Zhou X, Wong JK, Koemeter-Cox A, Martini M, Friedel RH, Zou H. HDAC3 inhibition ameliorates spinal cord injury by immunomodulation. Sci Rep. 2017. 7(1):8641.
Lagana A, Goetz JG, Y N, Altschuler Y, Nabi IR. pH-specific sequestration of phosphoglucose isomerase/autocrine motility factor by fibronectin and heparan sulphate. J Cell Sci. 2005. 118(Pt 18):4175-85.
Le Moan N, Baeten KM, Rafalski VA, Ryu JK, Rios Coronado PE, Bedard C, Syme C, Davalos D, Akassoglou K. Hypoxia Inducible Factor-1α in Astrocytes and/or Myeloid Cells Is Not Required for the Development of Autoimmune Demyelinating Disease. eNeuro. 2015. 2(2):ENEURO.0050-14.2015.
Leclerc N, Vallée A, Nabi IR. Expression of the AMF/neuroleukin receptor in developing and adult brain cerebellum. J Neurosci Res. 2000. 60(5):602-12.
Lee SH, Ko HM, Kwon KJ, Lee J, Han SH, Han DW, Cheong JH, Ryu JH, Shin CY. tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells. Mol Neurobiol. 2014. 49(1):199-215.
Lewy TG, Grabowski JM, Bloom ME. BiP: Master Regulator of the Unfolded Protein Response and Crucial Factor in Flavivirus Biology. Yale J Biol Med. 2017. 90(2):291-300.
Li Y, Jia Y, Bian Y, Tong H, Qu J, Wang K, Wan XP. Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1. Cell Commun Signal. 2019. 17(1):22.
Li Z, Zhang L, Zhao Y, Li H, Xiao H, Fu R, Zhao C, Wu H, Li Z. Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. Int J Biochem Cell Biol. 2013. 45(5):987-94.
Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA. Neurotoxic Reactive Astrocytes Are Induced by Activated Microglia. Nature. 2017. 541(7638):481 - 487.
Lin ML, Chen SS, Ng SH. CHM-1 Suppresses Formation of Cell Surface-associated GRP78-p85α Complexes, Inhibiting PI3K-AKT Signaling and Inducing Apoptosis of Human Nasopharyngeal Carcinoma Cells. Anticancer Res. 2015. 35(10):5359-68.
Lin CH, Lin W, Su YC, Cheng-Yo Hsuan Y, Chen YC, Chang CP, Chou W, Lin KC. Modulation of parietal cytokine and chemokine gene profiles by mesenchymal stem cell as a basis for neurotrauma recovery. J Formos Med Assoc. 2019. 118(12):1661-1673.
Liu W, Wang Y, Gong F, Rong Y, Luo Y, Tang P, Zhou Z, Zhou Z, Xu T, Jiang T, Yang S, Yin G, Chen J, Fan J, Cai
W. Exosomes Derived from Bone Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by Suppressing the Activation of A1 Neurotoxic Reactive Astrocytes. J Neurotrauma. 2019. 36(3):469-484.
Liotta LA, Mandler R, Murano G, Katz DA, Gordon RK, Chiang PK, Schiffmann E. Tumor cell autocrine motility factor. Proc. Natl. Acad. Sci. U.S.A. 1986. 83, 3302–3306.
Liu R, Li X, Gao W, Zhou Y, Wey S, Mitra SK, Krasnoperov V, Dong D, Liu S, Li D, Zhu G, Louie S, Conti PS, Li Z, Lee AS, Gill PS. Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis. Clin Cancer Res. 2013. 19(24):6802-11.
Lomenick B, Hao R, Jonai N, Chin RM, Aghajan M, Warburton S, Wang J, Wu RP, Gomez F, Loo JA, Wohlschlegel JA, Vondriska TM, Pelletier J, Herschman HR, Clardy J, Clarke CF, Huang J. Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A. 2009. 106(51):21984-9.
Louessard M, Bardou I, Lemarchand E, Thiebaut AM, Parcq J, Leprince J, Terrisse A, Carraro V, Fafournoux P, Bruhat A, Orset C, Vivien D, Ali C, Roussel BD. Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death. Cell Death Differ. 2017. 24 (9):1518-1529.
Lu P, Wang Y, Graham L, McHale K, Gao M, Wu D, Brock J, Blesch A, Rosenzweig ES, Havton LA, Zheng B, Conner JM, Marsala M, Tuszynski MH. Long-distance growth and connectivity of neural stem cells after severe spinal cord injury. Cell. 2012. 150(6):1264-73.
Lu Y, Yu SS, Zong M, Fan SS, Lu TB, Gong RH, Sun LS, Fan LY. Glucose-6-Phosphate Isomerase (G6PI) Mediates Hypoxia-Induced Angiogenesis in Rheumatoid Arthritis. Sci Rep. 2017. 7:40274.
Lucarelli G, Galleggiante V, Rutigliano M, Sanguedolce F, Cagiano S, Bufo P, Lastilla G, Maiorano E, Ribatti D, Giglio A, Serino G, Vavallo A, Bettocchi C, Selvaggi FP, Battaglia M, Ditonno P. Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma. Oncotarget. 2015. 6 (15): 13371-86.
Luo Y, Long JM, Lu C, Chan SL, Spangler EL, Mascarucci P, Raz A, Longo DL, Mattson MP, Ingram DK, Weng NP. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. J Neurochem. 2002. 80(2):354-61.
Marek R, Caruso M, Rostami A, Grinspan JB, Das Sarma J. Magnetic cell sorting: a fast and effective method of concurrent isolation of high purity viable astrocytes and microglia from neonatal mouse brain tissue. J Neurosci Methods. 2008. 175(1):108-18.
Matsumoto T, Tamaki T, Kawakami M, Yoshida M, Ando M, Yamada H. Early Complications of High-Dose Methylprednisolone Sodium Succinate Treatment in the Follow-Up of Acute Cervical Spinal Cord Injury. Spine (Phila Pa 1976). 2001. 26(4):426-30.
McCarthy KD, de Vellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol. 1980. 85(3):890-902.
Miao YR, Eckhardt BL, Cao Y, Pasqualini R, Argani P, Arap W, Ramsay RG, Anderson RL. Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78. Clin Cancer Res. 2013. 19(8):2107-16.
Mikami M, Sadahira Y, Haga A, Otsuki T, Wada H, Sugihara T. Hypoxia-inducible factor-1 drives the motility of the erythroid progenitor cell line, UT-7/Epo, via autocrine motility factor. Exp Hematol. 2005. 33(5):531-41.
Mishra S, Raz A, Murphy LJ. Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and inhibits the AMF/PGI function. Cancer Res. 2004. 64(7):2516-22.
Misra UK, Deedwania R, Pizzo SV. Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK. J Biol Chem. 2005. 280(28):26278-86.
Misra UK, Deedwania R, Pizzo SV. Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. J Biol Chem. 2006. 281(19):13694-707.
Muir GD, Whishaw IQ. Red nucleus lesions impair overground locomotion in rats: a kinetic analysis. Eur J Neurosci. 2000. 12(3):1113-22.
Murray KC, Nakae A, Stephens MJ, Rank M, D'Amico J, Harvey PJ, Li X, Harris RL, Ballou EW, Anelli R, Heckman CJ, Mashimo T, Vavrek R, Sanelli L, Gorassini MA, Bennett DJ, Fouad K. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med. 2010. 16(6):694-700.
Nagoshi N, Tsuji O, Kitamura K, Suda K, Maeda T, Yato Y, Abe T, Hayata D, Matsumoto M, Okano H, Nakamura
M. Phase I/II Study of Intrathecal Administration of Recombinant Human Hepatocyte Growth Factor in Patients with Acute Spinal Cord Injury: A Double-Blind, Randomized Clinical Trial of Safety and Efficacy. J Neurotrauma. 2020. doi: 10.1089/neu.2019.6854. Online ahead of print.
Nakajima S, Numakawa T, Adachi N, Ooshima Y, Odaka H, Yoshimura A, Kunugi H. Self-amplified BDNF transcription is a regulatory system for synaptic maturation in cultured cortical neurons. Neurochem Int. 2015. 91:55-61.
Nakamura M, Okano H. Cell Transplantation Therapies for Spinal Cord Injury Focusing on Induced Pluripotent Stem Cells. Cell Res. 2013. 23(1):70-80.
Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H. Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex. Diabetes. 2012 . 61(11):2823-32.
Ni M, Zhang Y, Lee AS. Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting. Biochem J. 2011. 434(2):181-8.
Ni M, Zhou H, Wey S, Baumeister P, Lee AS. Regulation of PERK signaling and leukemic cell survival by a novel cytosolic isoform of the UPR regulator GRP78/BiP. PLoS One. 2009. 4(8):e6868.
Niinaka Y, Paku S, Haga A, Watanabe H, Raz A. Expression and secretion of neuroleukin/phosphohexose isomerase/maturation factor as autocrine motility factor by tumor cells. Cancer Res. 1998. 58 (12): 2667-74.
Niizeki H, Kobayashi M, Horiuchi I, Akakura N, Chen J, Wang J, Hamada JI, Seth P, Katoh H, Watanabe H, Raz A, Hosokawa M. Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells. Br J Cancer. 2002. 86(12):1914-9.
Ohtake Y, Sami A, Jiang X, Horiuchi M, Slattery K, Ma L, Smith GM, Selzer ME, Muramatsu SI, Li S. Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1. Mol Ther. 2019. 27(1):102-117.
Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, Ishii K, Yamane J, Yoshimura A, Iwamoto Y, Toyama Y, Okano H. Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat. Med. 2006. 12, 829-834.
Ono K, Toyono T, Inenaga K. Nicotinic receptor subtypes in rat subfornical organ neurons and glial cells. Neuroscience. 2008. 154 (3): 994-1001.
Osaka M, Honmou O, Murakami T, Nonaka T, Houkin K, Hamada H, Kocsis DJ. Intravenous Administration of Mesenchymal Stem Cells Derived From Bone Marrow After Contusive Spinal Cord Injury Improves Functional Outcome. Brain Res. 2010. 1343:226-35.
Oshigiri T, Sasaki T, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Oka S, Morita T, Hirota R, Yoshimoto M, Yamashita T, Hashimoto-Torii K, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Alters Motor Cortex Gene Expression in a Rat Model of Acute Spinal Cord Injury. J Neurotrauma. 2019. 36(3):411-420.
Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia. 2005. 50(4):427-34.
Philippova M, Ivanov D, Joshi MB, Kyriakakis E, Rupp K, Afonyushkin T, Bochkov V, Erne P, Resink TJ. Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival. Mol Cell Biol. 2008. 28(12):4004-17.
Pollard ME, Apple DF. Factors Associated With Improved Neurologic Outcomes in Patients With Incomplete Tetraplegia. Spine (Phila Pa 1976). 2003. 28(1):33-9.
Qiao Y, Dsouza C, Matthews AA, Jin Y, He W, Bao J, Jiang F, Chandna R, Ge R, Fu L. Discovery of small molecules targeting GRP78 for antiangiogenic and anticancer therapy. Eur J Med Chem. 2020. 193:112228.
Read DE, Gorman AM. Involvement of Akt in neurite outgrowth. Cell Mol Life Sci. 2009. 66(18):2975-84.
Robbins HL, Hague A. The PI3K/Akt Pathway in Tumors of Endocrine Tissues. Front Endocrinol (Lausanne). 2016. 6:188.
Romagnoli A, Oliverio S, Evangelisti C, Iannicola C, Ippolito G, Piacentini M. Neuroleukin inhibition sensitises neuronal cells to caspase-dependent apoptosis. Biochem. Biophys. Res. Commun. 2003. 302(3):448-53.
Ruiz-Palmero I, Hernando M, Garcia-Segura LM, Arevalo MA. G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons. Mol Cell Endocrinol. 2013. 372(1-2):105-15.
Saura J, Tusell JM, Serratosa J. High-yield isolation of murine microglia by mild trypsinization. Glia. 2003. 44(3):183-9.
Shaikh H, Boudes E, Khoja Z, Shevell M, Wintermark P. Angiogenesis dysregulation in term asphyxiated newborns treated with hypothermia. PLoS One. 2015. 10(5):e0128028.
Shani G, Fischer WH, Justice NJ, Kelber JA, Vale W, Gray PC. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol. 2008. 28(2) 666-77.
Shankar J, Kojic LD, St-Pierre P, Wang PT, Fu M, Joshi B, Nabi IR.Raft endocytosis of AMF regulates mitochondrial dynamics through Rac1 signaling and the Gp78 ubiquitin ligase. J Cell Sci. 2013. 126(Pt 15):3295-304.
Shigyo M, Kuboyama T, Sawai Y, Tada-Umezaki M, Tohda C. Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth. Sci. Rep. 2015. 5, 12055.
Shigyo M, Tanabe N, Kuboyama T, Choi SH, Tohda C. New reliable scoring system, Toyama mouse score, to evaluate locomotor function following spinal cord injury in mice. BMC Res Notes. 2014. 7:332.
Shigyo M, Tohda C. Extracellular vimentin is a novel axonal growth facilitator for functional recovery in spinal cord-injured mice. Sci. Rep. 2016. 6:28293.
Shih CH, Lacagnina M, Leuer-Bisciotti K, Pröschel C. Astroglial-derived periostin promotes axonal regeneration after spinal cord injury. J Neurosci. 2014. 34(7):2438-43.
Shimizu K, Tani M, Watanabe H, Nagamachi Y, Niinaka Y, Shiroishi T, Ohwada S, Raz A, Yokota J. The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett. 1999. 456(2):295-300.
Shinozaki, Y., Shibata, K., Yoshida, K., Shigetomi, E., Gachet, C., Ikenaka, K, Tanaka KF, Koizumi S. Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y1 receptor downregulation. Cell Rep. 2017. 19, 1151–1164.
Silletti S, Watanabe H, Hogan V, Nabi IR, Raz A. Purification of B16-F1 melanoma autocrine motility factor and its receptor. Cancer Res. 1991. 51, 3507–3511.
Silver J, Miller JH. Regeneration beyond the glial scar. Nat. Rev. Neurosci. 2004. 5, 146–156.
Sofroniew MV, Vinters HV. Astrocytes: Biology and Pathology. Acta Neuropathol. 2010. 119(1):7-35.
Sun YJ, Chou CC, Chen WS, Wu RT, Meng M, Hsiao CD. The crystal structure of a multifunctional protein: phosphoglucose isomerase/autocrine motility factor/neuroleukin. Proc Natl Acad Sci U S A. 1999. 96(10):5412-7.
Sun FC, Wei S, Li CW, Chang YS, Chao CC, Lai YK. Localization of GRP78 to mitochondria under the unfolded protein response. Biochem J. 2006. 396(1):31-9.
Tanabe N, Kuboyama T, Kazuma K, Konno K, Tohda C. The Extract of Roots of Sophora flavescens Enhances the Recovery of Motor Function by Axonal Growth in Mice with a Spinal Cord Injury. Front Pharmacol. 2016. 6:326.
Tanabe N, Kuboyama T, Tohda C. Matrine directly activates extracellular heat shock protein 90, resulting in axonal growth and functional recovery in spinal cord injured-mice. Front. Pharmacol. 2018. 9:446.
Tanaka N, Haga A, Naba N, Shiraiwa K, Kusakabe Y, Hashimoto K, Funasaka T, Nagase H, Raz A, Nakamura KT. Crystal structures of mouse autocrine motility factor in complex with carbohydrate phosphate inhibitors provide insight into structure-activity relationship of the inhibitors. J Mol Biol. 2006. 356 (2): 312-24.
Tanie Y, Kuboyama T, Tohda C. GRP78-Mediated Signaling Contributes to Axonal Growth Resulting in Motor Function Recovery in Spinal Cord-Injured Mice. Front Pharmacol. 2020. 11:789.
Tanie Y, Tanabe N, Kuboyama T, Tohda C. Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth in vitro and in vivo. Front Pharmacol. 2018. 9:1228.
Tao B, Shi K. Decreased miR-195 Expression Protects Rats from Spinal Cord Injury Primarily by Targeting HIF-1α. Ann Clin Lab Sci. 2016. 46(1):49-53.
Teshigawara K, Kuboyama T, Shigyo M, Nagata A, Sugimoto Kf, Matsuya Y, Tohda C. A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin. Br. J. Pharmacol. 2013. 168, 903–919.
Tian K, Zhong W, Zheng X, Zhang J, Liu P, Zhang W, Liu H. Neuroleukin/autocrine motility factor receptor pathway promotes proliferation of articular chondrocytes through activation of AKT and Smad2/3. Sci. Rep. 2015. 5:15101.
Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T. Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012. 2:535.
Tsai MC, Shen LF, Kuo HS, Cheng H, Chak KF. Involvement of acidic fibroblast growth factor in spinal cord injury repair processes revealed by a proteomics approach. Mol Cell Proteomics. 2008. 7(9):1668-87.
Tsai MJ, Tsai SK, Huang MC, Liou DY, Huang SL, Hsieh WH, Huang WC, Huang SS, Cheng H. Acidic FGF promotes neurite outgrowth of cortical neurons and improves neuroprotective effect in a cerebral ischemic rat model. Neuroscience. 2015. 305:238-47.
Vig S, Buitinga M, Rondas D, Crèvecoeur I, van Zandvoort M, Waelkens E, Eizirik DL, Gysemans C, Baatsen P, Mathieu C, Overbergh L. Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells. Cell Death Dis. 2019. 10(4):309.
Walters BC, Hadley MN, Hurlbert RJ, Aarabi B, Dhall SS, Gelb DE, Harrigan MR, Rozelle CJ, Ryken TC, Theodore N; American Association of Neurological Surgeons; Congress of Neurological Surgeons. Guidelines for the Management of Acute Cervical Spine and Spinal Cord Injuries: 2013 Update. Neurosurgery. 2013. 60(CN_suppl_1):82-91.
Wang L, Pei S, Han L, Guo B, Li Y, Duan R, Yao Y, Xue B, Chen X, Jia Y. Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury. Cell Physiol Biochem. 2018. 50(4):1535-1559.
Watanabe H, Carmi P, Hogan V, Raz T, Silletti S, Nabi IR, Raz A. Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor. J. Biol. Chem. 1991. 266, 13442–13448.
Watanabe H, Takehana K, Date M, Shinozaki T, Raz A. Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide. Cancer Res. 1996. 56 (13): 2960-3.
Watari H, Shimada Y, Tohda C. Cytosolic aspartate aminotransferase, a direct binding protein of kamikihito, regulates axon growth. Traditional & Kampo Medicine. 2016. 3: 41–49
Widenfalk J, Lundströmer K, Jubran M, Brene S, Olson L. Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J. Neurosci. 2001. 21(10):3457-75.
Xiaowei H, Ninghui Z, Wei X, Yiping T, Linfeng X. The experimental study of hypoxia-inducible factor-1alpha and its target genes in spinal cord injury. Spinal Cord. 2006. 44(1):35-43.
Xin H, Li Y, Shen LH, Liu X, Wang X, Zhang J, Pourabdollah-Nejad D S, Zhang C, Zhang L, Jiang H, Zhang ZG, Chopp M. Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse. PLoS One. 2010. 5(2):e9027.
Xiu J, Nordberg A, Zhang JT, Guan ZZ. Expression of nicotinic receptors on primary cultures of rat astrocytes and up-regulation of the alpha7, alpha4 and beta2 subunits in response to nanomolar concentrations of the beta-amyloid peptide(1-42). Neurochem Int. 2005. 47(4): 281-90.
Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest. 2005. 115(10):2656-64.
Yanagawa T, Funasaka T, Tsutsumi S, Watanabe H, Raz A. Novel roles of the autocrine motility factor/phosphoglucose isomerase in tumor malignancy. Endocr Relat Cancer. 2004. 11(4):749-59.
Yang T, Dai Y, Chen G, Cui S. Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury. Front Cell Neurosci. 2020. 14:78.
Yang Z, Kuboyama T, Tohda C. A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer's Disease and Its Target Molecule. Front Pharmacol. 2017. 19; 8:340.
Yang Y, Cheng XR, Zhang GR, Zhou WX, Zhang YX. Autocrine motility factor receptor is involved in the process of learning and memory in the central nervous system. Behav Brain Res. 2012. 229(2):412-8.
Yin Y, Chen C, Chen J, Zhan R, Zhang Q, Xu X, Li D, Li M. Cell surface GRP78 facilitates hepatoma cells proliferation and migration by activating IGF-IR. Cell Signal. 2017. 35:154-162.
Yiu G, He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci. 2006. 7(8):617-27.
Yun SP, Kam T, Panicker N, Kim SM, Oh Y, Park J, Kwon S, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang S, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke VV, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS. Block of A1 Astrocyte Conversion by Microglia Is Neuroprotective in Models of Parkinson's Disease. Nat Med. 2018. 24(7):931-938.
Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA. Genomic analysis of reactive astrogliosis. J Neurosci. 2012. 32(18):6391-410.
Zhang Y, Tseng CC, Tsai YL, Fu X, Schiff R, Lee AS. Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production. PLoS One. 2013. 8(11):e80071.
Zhao Q, Du J, Gu H, Teng X, Zhang Q, Qin H, Liu N. Effects of YC-1 on hypoxia-inducible factor 1-driven transcription activity, cell proliferative vitality, and apoptosis in hypoxic human pancreatic cancer cells. Pancreas. 2007. 34(2):242-7.
Zhao T, Qi Y, Li Y, Xu K. PI3 Kinase regulation of neural regeneration and muscle hypertrophy after spinal cord injury. Mol Biol Rep. 2012. 39(4):3541-7.
Ziemlińska E, Kügler S, Schachner M, Wewiór I, Czarkowska-Bauch J, Skup M. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. PLoS One. 2014. 9(2):e88833.
安藤優子、ITB (髄腔内バクロフェン) 療法 - 日本における新しい重度攣縮の治療 -. 日薬理誌 (Foolia Pharmacol. Jpn.). 2008. 131, 109-114.
中野葵 Diosgenin の持続的髄腔内投与による慢性期脊髄損傷の運動機能回復 修士論文医学のあゆみ、271 巻 7 号、2019、医歯薬出版株式会社