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Apoptosis inhibitor of macrophage (AIM)/CD5Lの慢性閉塞性肺疾患における役割に関する研究

佐藤, 理子 北海道大学

2023.09.25

概要

【背景と目的】
慢性閉塞性肺疾患 (chronic obstructive pulmonary disease: COPD) はタバコ
煙を主とする有害物質の長期吸入曝露などにより 発症し, 末梢気道病変や
気腫性病変が生じることにより呼吸機能検査で 気流閉塞を示す. 世界保健
機関の調査では世界の死因第 3 位であり, 公衆衛生上の多大な負荷となっ
ている. 本邦においても有病率 8.6%, 患者数約 530 万人と推定され, 今後高
齢化が加速する社会において益々大きな問題となることが予想される . 気
管支拡張薬吸入, 呼吸不全に対しては酸素投与などの対症療法が行 われて
いるが抜本的な治療法はなく, 病態の解明および新規治療開発が切実に望
まれる.
Apoptosis inhibitor of macrophage (AIM)/CD5 molecule-like (CD5L) は血清
に 5 μg/ml 程度存在する分泌タンパクである. 血中では主に immunoglobulin
(Ig)M の 5 量体と結合して存在し, その濃度は IgM と相関する. AIM は各種
細胞のアポトーシス抑制のほか腎尿細管での老廃物排泄, 脂肪酸分解, T
helper 17 (Th17) 細胞の病態制御スイッチなどの様々な機能が判明している.
生体内において病態促進的・抑制的の両者の作用が知られているが, 当教室
の過去の 研究で は, 呼 吸器疾 患にお いて促 進的に作 用して いた . 現時点 で
COPD の病態における AIM の役割に関し ては報告が少ないが , 既報では
COPD 患者で肺胞マクロファージの生存維持に関与し, マウスモデルにお
いては AIM の過剰発現で肺気腫が誘導された. この度 AIM が COPD の病態
に促進的に作用すると仮説を立て実験を行った.
【材料と方法】
1. ...

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