[1] 内閣府、令和 3 年版高齢社会白書 "令和 2 年度高齢化の状況及び高齢社会対策の実施状
況", p. 2 (2021).
[2] Anneloes E. Gerritsen, P. Finbarr Allen, Dick J. Witter, Ewald M. Bronkhorst, Nico H. J.
Creugers, Tooth loss and oral health-related quality of life: a systematic review and meta-analysis,
Health Qual Life Outcomes, Vol. 8, 126 (2010).
DOI: 10.1186/1477-7525-8-126
[3] Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana
Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro
Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa, A Piezo1/KLF15/IL-6 axis mediates
immobilization-induced muscle atrophy, Journal of Clinical Investigation, Vol. 132 (10), pp. 1-13
(2022).
DOI: 10.1172/JCI154611
[4] Qian-Li Xue, Karen Bandeen-Roche, Ravi Varadhan, Jing Zhou, Linda P Fried, Initial
manifestations of frailty criteria and the development of frailty phenotype in the Women's Health
and Aging Study II, Journal of Gerontology: Biological Sciences and the Journal of Gerontology:
Medical Sciences, Vol. 63 (9), pp. 984-990 (2008).
DOI: 10.1093/gerona/63.9.984
[5] Tomoki Tanaka, Kyo Takahashi, Hirohiko Hirano, Takeshi Kikutani, Yutaka Watanabe, Yuki
Ohara, Hiroyasu Furuya, Tsuji Tetsuo, Masahiro Akishita, Katsuya Iijima, Oral Frailty as a Risk
Factor for Physical Frailty and Mortality in Community-Dwelling Elderly, The journals of
gerontology. Series A, Biological sciences and medical sciences, Vol. 73 (12), pp. 1661-1667
(2018).
DOI: doi: 10.1093/gerona/glx225
[6] 厚生労働省, "日本人の食事摂取基準" 2020 年版 (2020).
[7] H. Yamanaka, M. Nishi, T. Kanemaki, N. Hosoda, K. Hioki, M. Yamamoto, Preoperative
nutritional assessment to predict postoperative complication in gastric cancer patients, Journal of
Parenteral and Enteral Nutrition, Vol. 13 (3), pp. 286-291 (1989).
DOI: 10.1177/0148607189013003286
[8] Mary D. Litchford, Becky Dorner, Mary Ellen Posthauer, Malnutrition as a Precursor of Pressure
Ulcers, Advances in Wound Care, Vol. 3 (1), pp. 54-63 (2014).
DOI: 10.1089/wound.2012.0385
[9] L. Stopher, S. Jansen, Systematic review of the impact and treatment of malnutrition in patients
with chronic vascular wounds, Wound Practice & Research: Journal of the Australian Wound
Management Association, Vol. 25 (2), pp. 71-80 (2017).
ISSN:1837-6304
[10] Alfonso J. Cruz-Jentoft, Gülistan Bahat, Jürgen Bauer, Yves Boirie, Olivier Bruyère, Tommy
Cederholm, Cyrus Cooper, Francesco Landi, Yves Rolland, Avan Aihie Sayer, Stéphane M.
Schneider, Cornel C. Sieber, Eva Topinkova, Maurits Vandewoude, Marjolein Visser, Mauro
Zamboni, Sarcopenia: revised European consensus on definition and diagnosis, Age and Ageing,
Vol. 48 (1), pp. 16-31 (2019).
DOI: 10.1093/ageing/afy169
[11] Minoru Yamada , Shu Nishiguchi, Naoto Fukutani, Takanori Tanigawa, Taiki Yukutake, Hiroki
Kayama, Tomoki Aoyama, Hidenori Arai, Prevalence of sarcopenia in community-dwelling
Japanese older adults, Journal of the American Medical Directors Association, Vol. 14 (2), pp.
911-915 (2013).
DOI: 10.1016/j.jamda.2013.08.015.
[12] Akihiko Kitamura , Satoshi Seino , Takumi Abe , Yu Nofuji , Yuri Yokoyama , Hidenori
Amano , Mariko Nishi , Yu Taniguchi , Miki Narita , Yoshinori Fujiwara , Shoji Shinkai,
Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older
adults, Journal of Cachexia, Sarcopenia and Muscle, Vol. 12 (1), pp. 30-38 (2021).
DOI: 10.1002/jcsm.12651
[13] Seon Won Go , Young Hwa Cha, Jung A Lee, Hye Soon Park, Association between Sarcopenia,
Bone Density, and Health-Related Quality of Life in Korean Men Korean, Journal of General and
Family Medicine, Vol. 34 (4), pp. 281-288 (2013).
DOI: 10.4082/kjfm.2013.34.4.281
[14] Kazuya Tanimura , Susumu Sato , Yoshinori Fuseya , Koichi Hasegawa , Kiyoshi Uemasu ,
Atsuyasu Sato , Tsuyoshi Oguma , Toyohiro Hirai , Michiaki Mishima , Shigeo Muro , Quantitative
Assessment of Erector Spinae Muscles in Patients with Chronic Obstructive Pulmonary Disease.
Novel Chest Computed Tomography-derived Index for Prognosis, Observational Study, Annals of
the. American Thoracic Society, Vol. 13 (3), pp. 334-41 (2016).
DOI: 10.1513/AnnalsATS.201507-446OC
[15] Yoshihiro Kugimiya, Masanori Iwasaki, Yuki Ohara, Keiko Motokawa, Ayako Edahiro, Maki
Shirobe, Yutaka Watanabe, Yu Taniguchi, Satoshi Seino, Takumi Abe, Shuichi Obuchi, Hisashi
Kawai, Takeshi Kera, Yoshinori Fujiwara, Akihiko Kitamura, Kazushige Ihara, Hunkyung Kim,
Shoji Shinkai, Hirohiko Hirano, Association between sarcopenia and oral functions in
community-dwelling older adults: A cross-sectional study, Journal of Cachexia, Sarcopenia and
Muscle, 5 December, 2022 (2022).
DOI: 10.1002/jcsm.13145
[16] Ichiro Fujishima, Masako Fujiu-Kurachi, Hidenori Arai, Masamitsu Hyodo, Hitoshi Kagaya,
Keisuke Maeda, Takashi Mori, Shinta Nishioka, Fumiko Oshima, Sumito Ogawa, Koichiro Ueda,
Toshiro Umezaki, Hidetaka Wakabayashi, Masanaga Yamawaki, Yoshihiro Yoshimura, Sarcopenia
and dysphagia: Position paper by four professional organizations,Geriatrics & Gerontology
International, Vol. 19 (2), pp. 91-97 (2019).
DOI: 10.1111/ggi.13591
[17] 平畑典子, サルコペニアの摂食嚥下障害とは何か, 看護技術, 65 (6): 28-31, 2019.
[18] Keisuke Maeda, Miki Takaki, Junji Akagi, Decreased Skeletal Muscle Mass and Risk Factors
of Sarcopenic Dysphagia: A Prospective Observational Cohort Study, Journals of Gerontology
Series A: Biological Sciences and Medical Sciences, Vol. 72 (9), pp. 1290-1294 (2017).
DOI: 10.1093/gerona/glw190
[19] Ryuichi Shirahase, Yutaka Watanabe, Tohru Saito, Yusuke Sunakawa, Yuya Matsushita,
Hideki Tsugayasu, Yutaka Yamazaki, A Cross-Sectional Study on the Relationship between Oral
Function and Sarcopenia in Japanese Patients with Regular Dental Maintenance, International
Journal of Environmental Research and Public Health, Vol. 19 (9), 5178 (2022).
DOI: 10.3390/ijerph19095178
[20] 渡邊 裕, 口の機能の低下はどのように評価し予防できるか, 総合リハビリテーシ
ョン、Vol. 50 (8), pp. 937-944 (2022).
[21] 厚生労働省, "平成 28 年歯科疾患実態調査" (2017) .
[22] Shunsuke Minakuchi, Kazuhiro Tsuga, Kazunori Ikebe, Takayuki Ueda, Fumiyo Tamura, Kan
Nagao, Junichi Furuya, Koichiro Matsuo, Ken Yamamoto, Manabu Kanazawa, Yutaka Watanabe,
Hirohiko Hirano, Takeshi Kikutani, Kaoru Sakurai, Oral hypofunction in the older population:
Position paper of the Japanese Society of Gerodontology in 2016, Gerodontology, Vol. 35 (4), pp.
317-324 (2018).
DOI: 10.1111/ger.12347
[23] Liang-Kung Chen, Jean Woo, Prasert Assantachai, Tung-Wai Auyeung, Ming-Yueh Chou,
Katsuya Iijima, Hak Chul Jang, Lin Kang, Miji Kim, Sunyoung Kim, Taro Kojima, Masafumi
Kuzuya, Jenny S W Lee, Sang Yoon Lee, Wei-Ju Lee, Yunhwan Lee, Chih-Kuang Liang,
Jae-Young Lim, Wee Shiong Lim, Li-Ning Peng, Ken Sugimoto, Tomoki Tanaka, Chang Won Won,
Minoru Yamada, Teimei Zhang, Masahiro Akishita, Hidenori Arai, Asian Working Group for
Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment, Journal of the
American Medical Directors Association, Vol. 21 (3), pp. 300-307 (2020).
DOI: 10.1016/j.jamda.2019.12.012
[24] 平野浩彦, 渡辺 裕, 石山直欣, 渡辺郁馬, 鈴木隆雄, 那須郁夫, 老年者咀噛能力に影響
する因子の解析, 老年歯学, Vol. 9 (3), pp. 184-190 (1995).
[25] T. Shimizu, T. Ueda, K. Sakurai, New method for evaluation of tongue-coating status, Journal
of Oral Rehabilitation, Vol. 34 (6), pp. 442-447 (2007).
DOI: 10.1111/j.1365-2842.2007.01733.x
[26] H. Yamada, Y. Nakagawa, Y. Nomura, K. Yamamoto, M. Suzuki, N. Y. Watanabe, I. Saito, K.
Seto, Preliminary results of moisture checker for Mucus in diagnosing dry mouth, Oral Diseases,
Vol. 11 (6), pp. 405-407 (2005).
DOI: 10.1111/j.1601-0825.2005.01136.x
[27] A. Yamada, M. Kanazawa, Y. Komagamine, S. Minakuchi, Association between tongue and lip
functions and masticatory performance in young dentate adults, Journal of Oral Rehabilitation, Vol.
42 (11), pp. 833-839 (2015).
DOI: 10.1111/joor.12319
[28] Mineka Yoshikawa, Tatsuyuki Fukuoka, Takahiro Mori, Aya Hiraoka, Chiaki Higa, Azusa
Kuroki, Chiho Takeda, Mariko Maruyama, Mitsuyoshi Yoshida, Kazuhiro Tsuga, The Journal of
Dental Sciences, Vol. 16 (1), pp. 214-219 (2021).
DOI: 10.1016/j.jds.2020.06.005
[29] Hanako Uesugi and Hiroshi Shiga, Relationship between masticatory performance using a
gummy jelly and masticatory movement, Journal of Prosthodontic Research, Vol. 61 (4), pp.419-425
(2017).
DOI: 10.1016/j.jpor.2017.01.001
[30] Ruri Ohkuma, Ichiro Fujishima, Chieko Kojima, Kyoko Hojo, Itaru Takehara, Yutaka
Motohashi, Development of a questionnaire to screen dysphagia, The Japanese Journal of Dysphagia
Rehabilitation, Vol. 6 (1), pp. 3-8 (2002).
DOI: 10.32136/jsdr.6.1_3
[31] Maya Nakamura, Tomofumi Hamada, Akihiko Tanaka, Keitaro Nishi, Kenichi Kume, Yuichi
Goto, Mahiro Beppu, Hiroshi Hijioka, Yutaro Higashi, Hiroaki Tabata, Kazuki Mori, Yumiko
Mishima, Yoshinori Uchino, Kouta Yamashiro, Yoshiaki Matsumura, Hyuma Makizako, Takuro
Kubozono, Takayuki Tabira, Toshihiro Takenaka, Mitsuru Ohishi, Tsuyoshi Sugiura, Association of
Oral Hypofunction with Frailty, Sarcopenia, and Mild Cognitive Impairment: A Cross-Sectional
Study of Community-Dwelling Japanese Older Adults, Journal of Clinical Medicine, Vol. 10 (8),
1626 (pp. 1-12), (2021).
DOI: 10.3390/jcm10081626
[32] Franz Faul, Edgar Erdfelder, Albert-Georg Lang, Axel Buchner, G*Power 3: a flexible
statistical power analysis program for the social, behavioral, and biomedical sciences, Behavior
Research Methods, Vol. 39 (2), pp. 175-191 (2007).
DOI: 10.3758/bf03193146
[33] M. Maria Glymour, "Using Causal Diagrams to Understand Common Problems in Social
Epidemiology", J. Michael Oakes & Jay S. Kaufman (Eds.), Methods in Social Epidemiology, 2nd
Edition, pp. 458-492, Jossey-Bass, US (2017).
ISBN：978-1118505595
[34] 対馬栄輝, "医療系データ解析", 東京図書 (2021).
ISBN: 978-4-489-02358-3
[35] Kotomi Sakai, Enri Nakayama, Haruka Tohara, Osamu Takahashi, Sayako Ohnishi, Hidetaka
Tsuzuki, Mayumi Hayata, Takahiro Takehisa, Yozo Takehisa, Koichiro Ueda, Diagnostic accuracy
of lip force and tongue strength for sarcopenic dysphagia in older inpatients: A cross-sectional
observational study, Clin Nutrition, Vol. 38 (1), pp. 303-309 (2019).
DOI: 10.1016/j.clnu.2018.01.016
[36] Kotomi Sakai, Enri Nakayama, Haruka Tohara, Keiji Kodama, Takahiro Takehisa, Yozo
Takehisa, Koichiro Ueda, Relationship between tongue strength, lip strength, and nutrition-related
sarcopenia in older rehabilitation inpatients: a cross-sectional study, Clinical Interventions in Aging,
Vol. 12, pp. 1207-1214 (2017).
DOI: 10.2147/CIA.S141148
[37] Nami Machida, Haruka Tohara, Koji Hara, Ayano Kumakura, Yoko Wakasugi, Ayako Nakane,
Shunsuke Minakuchi, Effects of aging and sarcopenia on tongue pressure and jaw-opening force,
Geriatrics & Gerontology International, Vol. 17 (2), pp. 295-301 (2017).
DOI: 10.1111/ggi.12715
[38] Seungwoo Cha, Won-Seok Kim, Ki Woong Kim, Ji Won Han, Hak Chul Jang, Soo Lim,
Nam-Jong Paik, Sarcopenia is an Independent Risk Factor for Dysphagia in Community-Dwelling
Older Adults, Dysphagia, Vol. 34 (5), pp. 692-697 (2019).
DOI: 10.1007/s00455-018-09973-6
[39] Maya Nakamura, Tomofumi Hamada, Akihiko Tanaka, Keitaro Nishi, Kenichi Kume, Yuichi
Goto, Mahiro Beppu, Hiroshi Hijioka, Yutaro Higashi, Hiroaki Tabata, Kazuki Mori, Yumiko
Mishima, Yoshinori Uchino, Kouta Yamashiro, Yoshiaki Matsumura, Hyuma Makizako, Takuro
Kubozono, Takayuki Tabira, Toshihiro Takenaka, Mitsuru Ohishi, Tsuyoshi Sugiura, Association of
Oral Hypofunction with Frailty, Sarcopenia, and Mild Cognitive Impairment: A Cross-Sectional
Study of Community-Dwelling Japanese Older Adults, Journal of Clinical Medicine, Vol. 10 (8), pp.
1626 (2021).
DOI: 10.3390/jcm10081626
[40] Mizue Suzuki, Yosuke Kimura, Yuhei Otobe, Tomoe Kikuchi, Hiroaki Masuda, Ryota Taguchi,
Shu Tanaka, Yuya Narita, Shuhei Shino, Haruhiko Kusumi, Minoru Yamada, Relationship between
Sarcopenia and Swallowing Capacity in Community-Dwelling Older Women, Geriatrics &
Gerontology International, Vol. 66 (6), pp. 549-552 (2020).
DOI: 10.1159/000511359
[41] John A. Batsis, Dennis T. Villareal, Sarcopenic obesity in older adults: aetiology, epidemiology
and treatment strategies, Nature Reviews Endocrinology, 14 (9), pp. 513-537 (2018).
DOI: 10.1038/s41574-018-0062-9
[42] 松尾浩一郎, 谷口裕重, 中川量晴, 金澤 学, 古屋純一, 津賀一弘, 池邉一典, 上田貴之,
田村文誉, 永尾 寛, 山本 健, 櫻井 薫, 水口俊介, 急性期病院入院高齢者における口腔機能
低下と低栄養との関連性, 老年歯科医, Vol. 31 (2), pp. 123-133 (2016).
DOI: 10.11259/jsg.31.123
[43] Kenji Wakai, Mariko Naito Toru Naito, Masaaki Kojima, Haruo Nakagaki, Osami Umemura,
Makoto Yokota, Nobuhiro Hanada, Takashi Kawamura, Tooth loss and intakes of nutrients and
foods: a nationwide survey of Japanese dentists, Community Dentistry Oral Epidemiology, Vol. 38
(1), pp. 43-49 (2010).
[44] Mayu Hayashi, Katsutaro Morino, Kayo Harada, Itsuko Miyazawa, Miki Ishikawa, Takako
Yasuda, Yoshie Iwakuma, Kazushi Yamamoto, Motonobu Matsumoto, Hiroshi Maegawa, Atsushi
Ishikado, PLoS One, Vol. 17 (9), e0274465 (2022).
DOI: 10.1371/journal.pone.0274465
[45] 水口俊介, 津賀一弘, 池邉一典, 上田貴之, 田村文誉, 永尾寛, 古屋純一, 松尾浩一郎,
山本 健, 金澤 学, 渡邊 裕, 平野 浩彦, 菊谷 武, 櫻井 薫, 高齢期における口腔機能低下─
学会見解論文 2016 年度版─, 老年歯科医学, Vol. 31 (2), pp. 81-99 (2016).
DOI: 10.11259/jsg.31.81
[46] Noriko Takeuchi, Nanami Sawada, Daisuke Ekuni, Manabu Morita, Oral Factors as Predictors
of Frailty in Community-Dwelling Older People: A Prospective Cohort Study, International Journal
of Environmental Research and Public Health, Vol. 19 (3), pp. 1145 (2022).
DOI: 10.3390/ijerph19031145
[47] 伊藤加代子, 葭原明弘, 高野尚子, 石上和男, 清田義和, 井上 誠, 北原 稔, 宮崎秀夫,
オーラルディアドコキネシスの測定法に関する検討, 老年歯科医, Vol. 24 (1), pp. 48-54
(2009).
DOI: 10.11259/jsg.24.48
[48] Kuan-Cheng Chen, Tsung-Min Lee, Wei-Ting Wu, Tyng-Guey Wang, Der-Sheng Han, Ke-Vin
Chang, Assessment of Tongue Strength in Sarcopenia and Sarcopenic Dysphagia: A Systematic
Review and Meta-Analysi, Frontiers in Nutrition, Vol 8, 684840 (2021).
DOI: 10.3389/fnut.2021.684840
[49] Kentaro Okuno, Ryuichiro Kobuchi, Suguru Morita, Ayako Masago, Masaaki Imaoka, Kazuya
Takahashi, Relationships between the Nutrition Status and Oral Measurements for Sarcopenia in
Older Japanese Adults, Journal of Clinical Medicine, Vol. 11 (24), 7382 (2022).
DOI: 10.3390/jcm11247382
[50] 松尾浩一郎, 口腔機能低下症への対応と今後の方向性, 老年歯学医学, 33 (3), pp.
304-311 (2018).
[51] 池邉一典, 八田昂大, 三原佑介, 村上和裕, 口腔機能低下症」に関する論点整理, 老年歯
科医学, Vol. 34 (4), pp. 451-456 (2019).
DOI: 10.11259/jsg.34.451
[52] 竹内倫子, 澤田ななみ, 鷲尾憲文, 澤田弘一, 江國大輔, 森田 学, 地域在住高齢者にお
ける主観的認知機能低下と口腔機能およびソーシャル・キャピタルとの関連, 老年歯科医学,
Vol. 37 (2), pp. 64-75 (2022).
DOI: 10.11259/jsg.37.2_64
[53] Daisuke Yoshida, Takao Suzuki, Hiroyuki Shimada, Hyuntae Park, Hyuma Makizako,
Takehiko Doi, Yuya Anan, Kota Tsutsumimoto, Kazuki Uemura, Tadashi Ito, Sangyoon Lee, Using
two different algorithms to determine the prevalence of sarcopenia, Geriatrics & Gerontology
International, Vol. 14 (1), pp. 46-51 (2014).
DOI: 10.1111/ggi.12210
[54] Yutaka Watanabe, Hirohiko Hirano, Hidenori Arai, Shiho Morishita, Yuki Ohara, Ayako
Edahiro, Masaharu Murakami, Hiroyuki Shimada, Takeshi Kikutani, Takao Suzuki, Relationship
Between Frailty and Oral Function in Community-Dwelling Elderly Adults, Journal of the American
Geriatrics Society, Vol. 65 (1), pp. 66-76 (2017).
DOI: 10.1111/jgs.14355
[55] Masanori Iwasaki, Yuki Ohara, Keiko Motokawa, Misato Hayakawa, Maki Shirobe, Ayako
Edahiro, Yutaka Watanabe, Shuichi Awata, Tsuyoshi Okamura, Hiroki Inagaki, Naoko Sakuma,
Shuichi Obuchi, Hisashi Kawai, Manami Ejiri, Kumiko Ito, Yoshinori Fujiwara, Akihiko Kitamura,
Yu Nofuji, Takumi Abe, Katsuya Iijima, Tomoki Tanaka, Bo-Kyung Son, Shoji Shinkai, Hirohiko
Hirano, Population-based reference values for tongue pressure in Japanese older adults: A pooled
analysis of over 5,000 participants, Journal of Prosthodontic Research (2022, Early release).
DOI: 10.2186/jpr.JPR_D_21_00272
[56] 北海道国保連合会, "帯広市国民健康保険特定健康診査" (2015).
[57] Faisal F Hakeem, Eduardo Bernabé, Wael Sabbah, Association between oral health and frailty:
A systematic review of longitudinal studies, Gerodontology, Vol. 36 (3), pp. 205-215 (2019).
DOI: 10.1111/ger.12406
[58] 松尾浩一郎, 谷口裕重, 中川量晴, 金澤 学, 古屋純一, 津賀一弘, 池邉一典, 上田貴之,
田村文誉, 永尾 寛, 山本 健, 櫻井 薫, 水口俊介, 急性期病院入院高齢者における口腔機能
低下と低栄養との関連性, 老年歯科医学, Vol. 31 (2), pp. 123-133 (2016).
DOI: 10.11259/jsg.31.123
[59] Ya Su, Michiko Yuki, Mika Otsuki, Prevalence of stroke-related sarcopenia: A systematic
review and meta-analysis, Journal of Stroke and Cerebrovascular Diseases, Vol. 29 (9), 105092
(2020).
DOI: 10.1016/j.jstrokecerebrovasdis.2020.105092
[60] Tae Nyun Kim , Man Sik Park, Sae Jeong Yang, Hye Jin Yoo, Hyun Joo Kang, Wook Song, Ji
A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi, Kyung Mook Choi,
Prevalence and determinant factors of sarcopenia in patients with type 2 diabetes: the Korean
Sarcopenic Obesity Study (KSOS), Diabetes Care, Vol. 33 (7), pp. 1497-1499 (2010).
DOI: 10.2337/dc09-2310
[61] M. Locquet, O. Bruyère, L. Lengelé, J.Y. Reginster, C. Beaudart, Relationship between
smoking and the incidence of sarcopenia: The SarcoPhAge cohort, Public Health, Vol. 193 (4), pp.
101-108 (2021).
DOI: 10.1016/j.puhe.2021.01.017
[62] Zohre Najafi, Hadi Kooshyar, Reza Mazloom, Amin Azhari ,The Effect of Fun Physical
Activities on Sarcopenia Progression among Elderly Residents in Nursing Homes: a Randomized
Controlled Trial, Journal of Caring Sciences, Vol. 7 (3), pp. 137-142 (2018).
DOI: 10.15171/jcs.2018.022
[63] Konstantinos Prokopidis, Oliver C. Witard, Understanding the role of smoking and chronic
excess alcohol consumption on reduced caloric intake and the development of sarcopenia, Nutrition
Research Reviews , Vol. 35 (2), pp. 197-206 (2022).
DOI: 10.1017/S0954422421000135
Tables (1-3), Figure 1 and Supplementary Table 1
Table 1 サルコペニア 3 群間の対象患者の基本情報および全身既往歴に関する比較
データ数
All
Normal
N=290
n=235
適正、高 BMI
低 BMI
Sarcopenia
Sarcopenia
n=26
n=29
p-value
Analysis
基本情報
年齢（歳）
75.10±6.43
74.25±6.09
81.04±6.43
76.69±6.18
性別 男（%）
47.93
44.68
61.54
62.07
身長（cm）
157.19±8.84
157.80±8.88
153.04±7.35
<0.001***
0.073
155.96±8.87
0.037*
体重（kg）
59.08±10.41
60.46±9.83
57.97±10.14
48.92±9.72
<0.001***
BMI（kg/m2）
23.67±3.29
24.17±3.22
23.82±1.68
19.51±1.58
<0.001***
サルコペニア診断
握力（kgf）
27.19±9.16
28.31±9.29
23.33±6.07
21.60±7.41
<0.001***
歩行速度 (m/s）
1.07±0.26
1.11±0.25
0.89±0.20
0.97±0.26
<0.001***
SMI（kg/m2）
6.69±0.95
6.86±0.91
6.11±0.63
5.83±0.86
<0.001***
全身既往歴
高血圧（%）
40.69
42.55
38.46
27.59
0.293
糖尿病（%）
18.28
15.32
30.77
31.03
0.027*
脂質異常症（%)
21.03
22.55
11.54
17.24
0.370
循環器疾患（％）
15.52
15.74
19.23
10.34
0.646
悪性腫瘍（％）
12.07
11.49
7.69
20.69
0.276
BMI. Body Mass Index, SMI. Skeletal muscle Mass Index
a. Kruskal-Wallis Test,
b. Chi-Squared Test *. p<0.05 **. p<0.01 ***. p<0.001
Table 2 サルコペニア 3 群間の対象患者の口腔機能に関する比較
All
データ数
N=290
適正、高 BMI
低 BMI
Sarcopenia
Sarcopenia
n=26
n=29
p-value
Normal
n=235
Analysis
口腔機能
口腔衛生状態（%） 34.04±18.04
33.83±18.08
34.19±20.10
35.58±16.22
0.772
口腔粘膜湿潤度（%） 26.69±3.20
26.87±3.16
25.69±3.22
26.19±3.41
0.088
16.70±8.57
17.50±8.22
10.77±9.88
15.55±8.15
0.003**
6.13±0.92
6.19±0.86
5.96±1.02
5.77±1.17
0.151
[ta]（回/秒）
6.05±0.86
6.10±0.85
5.90±0.76
5.78±0.99
0.148
[ka]（回/秒）
5.59±0.93
5.67±0.89
5.29±0.88
5.18±1.17
0.004**
30.31±7.69
31.30±7.37
25.73±8.19
26.40±7.23
<0.001***
184.50±59.80
168.54±55.75
168.83±52.33
残存歯数（数）
舌口唇運動機能
[pa]（回/秒）
舌圧（kPa）
咀嚼機能（mg/dL） 181.50±58.89
嚥下機能（％）
22.76
20.42
19.23
44.83
0.204
0.011*
口腔機能低下該当項
2.67±1.29
目数（数）
2.51±1.24
3.35±1.41
3.41±1.24
<0.001***
口腔機能低下症の有
無（%）
機能歯数（数）
54.48
50.21
73.08
75.86
0.006**
27.50±0.95
27.52±0.88
27.31±1.49
27.48±0.87
0.962
65.96
76.92
65.52
0.522
可撤性義歯使用（％） 66.90
プロービングデプス
（mm）
BOP（%）
8.95±12.74
7.75±10.34
16.67±24.83
12.62±14.73
0.191
4.83±8.15
4.05±5.89
9.40±16.89
7.51±11.75
0.227
BOP. Bleeding on Probing, †. 嚥下機能低下者の割合
a. Kruskal-Wallis Test,
b. Chi-Squared Test
*. p<0.05,
**. p<0.01,
***. p<0.001
Table 3 サルコペニア 3 群間と口腔機能との関連（N＝290）
適正 or
高 BMI＋サルコペニア
低 BMI＋サルコペニア
OR
95 % CI
OR
95 % CI
口腔衛生状態（%）
0.99
0.97-1.01
1.00
0.98-1.02
口腔粘膜湿潤度（%）
0.91
0.81-1.02
0.94
0.84-1.05
残存歯数（数）
0.93
0.89-0.98**
0.98
0.93-1.03
[pa]（回/秒）
0.95
0.58-1.54
0.70
0.48-1.013
[ta]（回/秒）
1.00
0.58-1.73
0.71
0.47-1.10
[ka]（回/秒）
0.90
0.55-1.48
0.67
0.45-0.98*
舌圧（kPa）
0.92
0.86-0.98**
0.91
0.86-0.96***
咀嚼機能（mg/dL）
1.00
0.99-1.01
1.00
0.99-1.00
嚥下機能（%）
0.87
0.30-2.58
3.05
1.36-6.84**
可撤性義歯の使用（数）
1.17
0.42-3.23
0.86
0.37-2.00
機能歯数（数）
0.80
0.53-1.21
0.92
0.61-1.38
1.53
0.57-4.08
2.75
1.10-6.88**
1.34
0.92-1.94
1.69
1.22-2.34**
舌口唇運動機能
口腔機能低下症の有無（%）
口腔機能低下該当項目数
（%）
OR. Odds Ratio , 95 % CI. 95 % Confidence Interval (CI)
*. p<0.05, **. p<0.01, ***. p<0.001
Figure 1 パスモデル（口腔機能の低下が及ぼすサルコペニアおよび低 BMI の影響）
Supplementary Table 1 口腔機能低下症に及ぼすサルコペニアおよび BMI の影響（N＝290）
項目
因果関係
[ka]音
[ka]音
舌圧
舌圧
舌圧
サルコペニア有無
サルコペニア有無
サルコペニア有無
嚥下機能低下有無
低 BMI 有無
低 BMI 有無
低 BMI 有無
低 BMI 有無
推定値
標準誤差
検定統計量
p-value
年齢
-0.033
0.008
-4.042
<0.001
-0.254
0.106
-2.397
0.017
年齢
-0.300
0.067
-4.456
<0.001
3.282
0.848
3.869
<0.001
[ka]音
1.742
0.467
3.732
<0.001
年齢
0.012
0.004
3.314
<0.001
0.113
0.044
2.563
0.010
-0.012
0.003
-4.054
<0.001
サルコペニア有無
0.123
0.062
1.968
0.049
嚥下機能低下有無
0.166
0.054
3.096
0.002
サルコペニア有無
0.369
0.061
6.048
<0.001
年齢
-0.013
0.004
-3.464
<0.001
舌圧
-0.006
0.003
-2.073
0.038
舌圧
...
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