ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen

概要

One in eight women has breast cancer (BC) in their lifetime, and
approximately 67%–80% of BCs are estrogen receptor positive
(ER+).1,2 Approximately 5%–10% of BCs are hereditary, with mutations in the BRCA1, BRCA2, and ATM (ataxia telangiectasia
mutated) genes accounting for most cases.3–6 Approximately
0.5%–1% of the general population carries a germline mutation
in the ATM gene.7 Women carrying these germline mutations
develop BC with high penetrance after loss of their intact ATM
allele.4,5,8,9 Mechanistically, this loss causes ER+ BCs, while
loss of the intact BRCA1 or BRCA2 allele causes ER-negative
BCs.6,10 Considering that the loss of heterozygosity (LOH)
events occurs at extremely low frequency (approximately 10
5
per base) even in cancer cells, the loss of ATM in a small number ...

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