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Validation of a point-of-care quantitative immunoassay for total bile acid measurement in dogs and cats

Chiku, Hiroyuki Asai, Tomohito 北海道大学

2021.05

概要

Total bile acid (TBA) concentrations in the blood are measured using an enzymatic method and an automated chemistry analyzer to evaluate liver function in dogs and cats. This study aimed to validate the results of FUJI DRI-CHEM IMMUNO AU in the measurement of TBA concentrations (FDC v-BA; FUJIFILM Corporation, Tokyo, Japan). Serum and plasma samples from dogs and cats were analyzed using FDC v-BA; intra- and interassay precision, accuracy, correlation, and linearity were evaluated. The correlation between FDC v-BA and an automated chemistry analyzer was also statistically assessed. Intra-assay (between 0.8% and 1.34%) and interassay (1.22%) coefficients of variation were determined, and the linearity of canine and feline serum samples showed excellent correlations (correlation coefficient for dogs and cats: R = 1.00 and 1.00). Analysis results of the canine and feline plasma samples by using FDC v-BA were highly correlated with those obtained using the enzymatic method (R = 0.976 for dogs and 0.979 for cats). The cross-reactivity of FDC v-BA with ursodeoxycholic acid was lower than with the enzymatic reagent. FDC v-BA was used to determine the reference intervals. The fasting reference intervals were ≤7.9 μmol/L for dogs and ≤4.7 μmol/L for cats, and the postprandial values were ≤26.2 μmol/L for dogs and ≤9.1 μmol/L for cats. TBA concentrations in dogs with a portosystemic shunt exceeded the reference range when measured with FDC v-BA, demonstrating the validity of our reference ranges. Thus, FDC v-BA can be a useful point-of-care test for clinical diagnoses in dogs and cats.

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