1. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 11(2):85-97, 2011
2. McVinnie DS. Obesity and pain. Br J Pain. 7(4):163-170, 2013
3. Chung F, Ritchie E, Su J. Postoperative pain in ambulatory surgery. Anesth Analg. 85(4):808-816, 1997
4. Stone AA, Broderick JE. Obesity and pain are associated in the United States. Obesity. 20(7):1491-1495, 2012
5. Okifuji A, Hare BD. The association between chronic pain and obesity. J Pain Res. 8:399-408, 2015
6. Sandell LJ. Obesity and osteoarthritis: Is leptin the link? Arthritis Rheum. 60(10):2858-2860, 2009
7. Briggs MS, Givens DL, Schmitt LC, Taylor CA. Relations of C-reactive protein and obesity to the prevalence and the odds of reporting low back pain. Arch Phys Med Rehabil. 94(4):745-752, 2013
8. Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta. 380(1-2):24-30, 2007
9. Yamauchi T, Kamon J, Minokoshi Y, Ito H, Waki S, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 8(11):1288-1295, 2002
10. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matuszawa Y. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway. Circulation. 102:1296-1301, 2000
11. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadokawa T. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 423(6941):762-769, 2003
12. Yamauchi T, Nio Y, Maki T, Koabayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadokawa T. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med. 13(3):332-339, 2007
13. Siitonen N, Pulkkinen L, Lindström J, Kolehmainen M, Schwab U, Eriksson JG, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M. Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study. Cardiovasc Diabetol. 10(1):83, 2011
14. Rasmussen-Torvik LJ, Pankow JS, Jacobs DR, Steinberger J, Moran A, Sinaiko AR. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Hum Genet. 125(1):21-28, 2009
15. Siitonen N, Pulkkinen L, Mager U, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. Diabetologia. 49(8):1795-1805, 2006
16. Mora-García G, Ruiz-Díaz MS, Espitia-Almeida F, Gómez-Camargo D. Variations in ADIPOR1 but not ADIPOR2 are associated with hypertriglyceridemia and diabetes in an admixed Latin American population. Rev Diabet Stud. 14(2-3):311-328, 2017
17. Lötsch J, Geisslinger G. Current evidence for a modulation of nociception by human genetic polymorphisms. Pain. 132(1):18-22
18. Fernandez Robles CR, Degnan M, Candiotti KA. Pain and genetics. Curr Opin Anaesthesiol. 25(4):444-449, 2012
19. Hoofwijk DMN, van Reij RRI, Rutten BP, Kenis G, Buhre WF, Joosten EA. Genetic polymorphisms and their association with the prevalence and severity of chronic postsurgical pain: a systematic review. Br J Anaesth. 117(6):708-719, 2016
20. Hozumi J, Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Kusakae Y, Yamada Y. Resistin is a novel marker for postoperative pain intensity. Anesth Analg. 128(3):563-568, 2019
21. Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A. Combined catechol-O-methyltransferase and μ-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects. Anesth Analg. 112(2):448-453, 2011
22. Campa D, Gioia A, Tomei A, Poli P, Barale R. Association of ABCB1/MDR1 and OPRM1 Gene Polymorphisms With Morphine Pain Relief. Clin Pharmacol Ther. 83(4):559-566, 2008
23. Kobayashi H, Otsuka H, Yanai M, Hara M, Hishiki M, Soma M, Abe M. Adiponectin Receptor gene Polymorphisms are Associated with Kidney Function in Elderly Japanese Populations. J Atheroscler Thromb. 26(4):328-339, 2019
24. Carvalho B, Clark DJ, Angst MS. Local and Systemic Release of Cytokines, Nerve Growth Factor, Prostaglandin E2, and Substance P in Incisional Wounds and Serum Following Cesarean Delivery. J Pain. 9(7):650-657, 2008
25. Hurley RW, Wu CL. 87 Acute Postoperative Pain. Miller’s Anesthesia 7th edition. Miller RD. 2757-2781, 2010
26. Scholz J, Woolf CJ. The neuropathic pain triad: Neurons, immune cells and glia. Nat Neurosci. 10(11):1361-1368, 2007
27. Sag D, Carling D, Stout RD, Suttles J. Adenosine 5’-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol. 181(12):8633-8641, 2008
28. Cohen SS, Gammon MD, North KE, Millikan RC, Lange EM, Williams SM, Zheng W, Cai Q, Long J, Smith JR, Signorello LB, Blot WJ, Matthews CH. ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women. Obesity. 19(10):2053-2062, 2011
29. Peters KE, Beilby J, Cadby G, Warrington NM, Bruce DG, Davis WA, Davis TME, Wiltshire S, Knuiman M, McQuillan BM, Palmer LJ, Thompson PL, Hung J. A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. BMC Med Genet. 14(1):15, 2013
30. Iannitti T, Graham A, Dolan S. Adiponectin-mediated analgesia and anti-inflammatory effects in rat. PLoS One. 10(9):1-13, 2015
31. Sun L, Li H, Tai LW, Gu P, Cheung CW. Adiponectin regulates thermal nociception in a mouse model of neuropathic pain. Br J Anaesth. 120(6):1356-1367, 2018
32. Neumeier M, Weigert J, Buettner R, Wanniger J, Schäffler A, Müller AM, Killian S, Sauerbruch S, Schlachetzki F, Steinbrecher A, Aslanidis C, Schölmerich J, Buechler C. Detection of adiponectin in cerebrospinal fluid in humans. Am J Physiol Metab. 293(4):E965-E969, 2007
33. Inoue K, Tsuda M. Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci. 19(3):138-152, 2018
34. Svensson CI, Marsala M, Westerlund A, Calcutt NA, Campana WM, Freshwater JD, Catalano R, Feng Y, Protter AA, Scott B, Yaksh TK. Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. J Neurochem. 86(6):1534-1544, 2003
35. Wen YR, Suter MR, Ji RR, Yeh GC, Wu YS, Wang KC, Kohno T, Sun WZ, Wang CC. Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia. Anesthesiology. 110(1):155-165, 2009
36. Halvatsiotis I, Tsiotra PC, Ikonomidis I, Kollias A, Mitrou P, Maratou E, Boutati E, Lekakis J, Dimitriadis G, Economopoulos T, Kremastinos DT, Raptis SA. Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. Cardiovasc Diabetol. 9:10, 2010
37. Kaarniranta K, Paananen J, Nevalainen T, Sorri I, Seitsonen S, Immonen I, Salminen A, Pulkkinen L, Uusitupa M. Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population. Neurosci Lett. 513(2):233-237, 2012
38. Chen M, Xu H. Parainflammation, chronic inflammation, and age-related macular degeneration. J Leukoc Biol. 98(5):713-725, 2015
39. Kuan YH, Shyu BC. Nociceptive transmission and modulation via P2X receptors in central pain syndrome. Mol Brain. 9(1):58, 2016