1 Howell, W. H. The New Morphological Element of the Blood. Science 3, 46-48, doi:10.1126/science.ns-3.49.46 (1884).
2 Dawson, D. W. & Bury, H. P. The significance of Howell-Jolly bodies and giant metamyelocytes in marrow smears. J Clin Pathol 14, 374-380, doi:10.1136/jcp.14.4.374 (1961).
3 Sears, D. A. & Udden, M. M. Howell-Jolly bodies: a brief historical review. Am J Med Sci 343, 407-409, doi:10.1097/MAJ.0b013e31823020d1 (2012).
4 Luzhna, L., Kathiria, P. & Kovalchuk, O. Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond. Front Genet 4, 131, doi:10.3389/fgene.2013.00131 (2013).
5 Krupina, K., Goginashvili, A. & Cleveland, D. W. Causes and consequences of micronuclei. Curr Opin Cell Biol 70, 91-99, doi:10.1016/j.ceb.2021.01.004 (2021).
6 Miller, K. N., Dasgupta, N., Liu, T., Adams, P. D. & Vizioli, M. G. Cytoplasmic chromatin fragments-from mechanisms to therapeutic potential. Elife 10, doi:10.7554/eLife.63728 (2021).
7 Jagetia, G. C. & Adiga, S. K. Correlation between micronuclei induction and cell survival in V79 cells exposed to paclitaxel (taxol) in conjunction with radiation. Mutat Res 377, 105-113, doi:10.1016/s0027-5107(97)00067-5 (1997).
8 Morita, T., MacGregor, J. T. & Hayashi, M. Micronucleus assays in rodent tissues other than bone marrow. Mutagenesis 26, 223-230, doi:10.1093/mutage/geq066 (2011).
9 Fenech, M. & Morley, A. A. Measurement of micronuclei in lymphocytes. Mutat Res 147, 29-36, doi:10.1016/0165-1161(85)90015-9 (1985).
10 Watters, G. P., Smart, D. J., Harvey, J. S. & Austin, C. A. H2AX phosphorylation as a genotoxicity endpoint. Mutat Res 679, 50-58, doi:10.1016/j.mrgentox.2009.07.007 (2009).
11 Wolf, K. et al. Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. J Cell Biol 201, 1069-1084, doi:10.1083/jcb.201210152 (2013).
12 Denais, C. M. et al. Nuclear envelope rupture and repair during cancer cell migration. Science 352, 353-358, doi:10.1126/science.aad7297 (2016).
13 Raab, M. et al. ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death. Science 352, 359-362, doi:10.1126/science.aad7611 (2016).
14 Dou, Z. et al. Autophagy mediates degradation of nuclear lamina. Nature 527, 105-109, doi:10.1038/nature15548 (2015).
15 Mochida, K. et al. Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus. Nature 522, 359-362, doi:10.1038/nature14506 (2015).
16 Rello-Varona, S. et al. Autophagic removal of micronuclei. Cell Cycle 11, 170- 176, doi:10.4161/cc.11.1.18564 (2012).
17 Zink, D., Fischer, A. H. & Nickerson, J. A. Nuclear structure in cancer cells. Nat Rev Cancer 4, 677-687, doi:10.1038/nrc1430 (2004).
18 Dou, Z. et al. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature 550, 402-406, doi:10.1038/nature24050 (2017).
19 Bakhoum, S. F. et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature 553, 467-472, doi:10.1038/nature25432 (2018).
20 Zhang, C. Z. et al. Chromothripsis from DNA damage in micronuclei. Nature. 522, 179-184, doi:10.1038/nature14493 (2015).
21 S. Yue. et al., Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging. Aging Cell. 18(4), doi: 10.1111/acel.12952 (2019)
22 Amy H. Yang et al., Chromosome Segregation Defects Contribute to Aneuploidy in Normal Neural Progenitor Cells. J Neuro Sci. 23(32):10454 – 10462. (2003)
23 Migliore, L., Coppede, F., Fenech, M. & Thomas, P. Association of micronucleus frequency with neurodegenerative diseases. Mutagenesis 26, 85- 92, doi:10.1093/mutage/geq067 (2011).
24 Jaiswal, M., LaRusso, N. F., Burgart, L. J. & Gores, G. J. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res 60, 184-190 (2000).
25 Sommer, S., Buraczewska, I. & Kruszewski, M. Micronucleus Assay: The State of Art, and Future Directions. Int J Mol Sci 21, doi:10.3390/ijms21041534 (2020).
26 Shibai-Ogata, A., Kakinuma, C., Hioki, T. & Kasahara, T. Evaluation of high- throughput screening for in vitro micronucleus test using fluorescence-based cell imaging. Mutagenesis 26, 709-719, doi:10.1093/mutage/ger037 (2011).
27 Wilson, A. et al. Transforming early pharmaceutical assessment of genotoxicity: applying statistical learning to a high throughput, multi end point in vitro micronucleus assay. Sci Rep 11, 2535, doi:10.1038/s41598-021-82115-5 (2021)
28 Shuryak, I. et al. Machine learning methodology for high throughput personalized neutron dose reconstruction in mixed neutron + photon exposures. Sci Rep 11, 4022, doi:10.1038/s41598-021-83575-5 (2021)
29 Tsuruta, F., Okajima, T., Yano, S. & Chiba, T. Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes. J Vis Exp, doi:10.3791/55488 (2017).
30 Okun, E., Griffioen, K. J. & Mattson, M. P. Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci 34, 269-281, doi:10.1016/j.tins.2011.02.005 (2011).
31 Probert, L. TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects. Neuroscience 302, 2-22, doi:10.1016/j.neuroscience.2015.06.038 (2015).
32 Ablasser, A. & Chen, Z. J. cGAS in action: Expanding roles in immunity and inflammation. Science 363, doi:10.1126/science.aat8657 (2019).
33 Cui-Wang, T. et al. Local zones of endoplasmic reticulum complexity confine cargo in neuronal dendrites. Cell 148, 309-321, doi:10.1016/j.cell.2011.11.056 (2012).
34 Spacek, J. & Harris, K. M. Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J Neurosci 17, 190-203 (1997).
35 Paul, B. D., Snyder, S. H. & Bohr, V. A. Signaling by cGAS-STING in Neurodegeneration, Neuroinflammation, and Aging. Trends Neurosci 44, 83-96, doi:10.1016/j.tins.2020.10.008 (2021).
36 Yu, C. H. et al. TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS. Cell 183, 636-649 e618, doi:10.1016/j.cell.2020.09.020 (2020).
37 Smith, H. L. et al. Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration. Neuron 105, 855-866 e855, doi:10.1016/j.neuron.2019.12.014 (2020).
38 Zhao, J. et al. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Sci Rep 9, 5790, doi:10.1038/s41598-019-42286- 8 (2019).
39 Li, Q. & Barres, B. A. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol 18, 225-242, doi:10.1038/nri.2017.125 (2018).
40 Wolf, S. A., Boddeke, H. W. & Kettenmann, H. Microglia in Physiology and Disease. Annu Rev Physiol 79, 619-643, doi:10.1146/annurev-physiol-022516- 034406 (2017).
41 Masuda, T., Sankowski, R., Staszewski, O. & Prinz, M. Microglia Heterogeneity in the Single-Cell Era. Cell Rep 30, 1271-1281, doi:10.1016/j.celrep.2020.01.010 (2020).
42 Keren-Shaul, H. et al. A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. Cell 169, 1276-1290 e1217, doi:10.1016/j.cell.2017.05.018 (2017).
43 M. van der Poel, M. et al. Transcriptional profiling of human microglia reveals grey-white matter heterogeneity and multiple sclerosis-associated changes. Nat Commun 10, 1139, doi:10.1038/s41467-019-08976-7 (2019).
44 Nimmerjahn, A., Kirchhoff, F. & Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314- 1318, doi:10.1126/science.1110647 (2005).
45 Haynes, S. E. et al. The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 9, 1512-1519, doi:10.1038/nn1805 (2006).
46 Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S. & Nabekura, J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 29, 3974-3980, doi:10.1523/JNEUROSCI.4363-08.2009 (2009).
47 Davalos, D. et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 8, 752-758, doi:10.1038/nn1472 (2005).
48 Cunningham, C. L., Martinez-Cerdeno, V. & Noctor, S. C. Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J Neurosci 33, 4216-4233, doi:10.1523/JNEUROSCI.3441-12.2013 (2013).
49 Perez-Pouchoulen, M., VanRyzin, J. W. & McCarthy, M. M. Morphological and Phagocytic Profile of Microglia in the Developing Rat Cerebellum. eNeuro 2, doi:10.1523/ENEURO.0036-15.2015 (2015).
50 Block, M. L., Zecca, L. & Hong, J. S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8, 57-69, doi:10.1038/nrn2038 (2007).
51 Crasta, K. et al. DNA breaks and chromosome pulverization from errors in mitosis. Nature 482, 53-58, doi:10.1038/nature10802 (2012).
52 Shi, L., Qalieh, A., Lam, M. M., Keil, J. M. & Kwan, K. Y. Robust elimination of genome-damaged cells safeguards against brain somatic aneuploidy following Knl1 deletion. Nat Commun 10, 2588, doi:10.1038/s41467-019-10411-w (2019).
53 Tabata, H. & Nakajima, K. Efficient in utero gene transfer system to the developing mouse brain using electroporation: visualization of neuronal migration in the developing cortex. Neuroscience 103, 865-872, doi:10.1016/s0306-4522(01)00016-1 (2001).
54 Komatsu, M. et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169, 425-434, doi:10.1083/jcb.200412022 (2005).
55 Mo, A. et al. Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain. Neuron 86, 1369-1384, doi:10.1016/j.neuron.2015.05.018 (2015).
56 Moriyama, M., Koshiba, T. & Ichinohe, T. Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nat Commun 10, 4624, doi:10.1038/s41467-019-12632-5 (2019).
57 Goebbels, S. et al. Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice. Genesis 44, 611-621, doi:10.1002/dvg.20256 (2006).
58 Kim, J. et al. USP15 Deubiquitinates TUT1 Associated with RNA Metabolism and Maintains Cerebellar Homeostasis. Mol Cell Biol 40, doi:10.1128/MCB.00098-20 (2020).
59 Tabata, H. & Nakajima, K. Labeling embryonic mouse central nervous system cells by in utero electroporation. Dev Growth Differ 50, 507-511, doi:10.1111/j.1440-169X.2008.01043.x (2008).
60 Morrison, H., Young, K., Qureshi, M., Rowe, R. K. & Lifshitz, J. Quantitative microglia analyses reveal diverse morphologic responses in the rat cortex after diffuse brain injury. Sci Rep 7, 13211, doi:10.1038/s41598-017-13581-z (2017).
61 Mure, K., Takeshita, T. & Morimoto, K. Categorization of micronuclei by size and measurement of each ratio in cytokinesis-block and conventional cultures of human lymphocytes exposed to mitomycin C and colchicine. Environ Health Prev Med 1, 93-99, doi:10.1007/BF02931197 (1996).
62 Sekine, K., Honda, T., Kawauchi, T., Kubo, K. & Nakajima, K. The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent "inside-out" lamination in the neocortex. J Neurosci 31, 9426-9439, doi:10.1523/JNEUROSCI.0650-11.2011 (2011).
63 Kubo, K. et al. Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex. J Neurosci 30, 10953-10966, doi:10.1523/JNEUROSCI.0486-10.2010 (2010).
64 Kaizuka, T. et al. An Autophagic Flux Probe that Releases an Internal Control. Mol Cell 64, 835-849, doi:10.1016/j.molcel.2016.09.037 (2016).
65 Chennakrishnaiah, S. et al. Extracellular vesicles from genetically unstable, oncogene-driven cancer cells trigger micronuclei formation in endothelial cells. Sci Rep 10, 8532, doi:10.1038/s41598-020-65640-7 (2020).
66 Ginhoux, F., Lim, S., Hoeffel, G., Low, D. & Huber, T. Origin and differentiation of microglia. Front Cell Neurosci 7, 45, doi:10.3389/fncel.2013.00045 (2013).
67 Bennett, M. L. et al. New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci U S A 113, E1738-1746, doi:10.1073/pnas.1525528113 (2016).
68 Harding, S. M. et al. Mitotic progression following DNA damage enables pattern recognition within micronuclei. Nature 548, 466-470, doi:10.1038/nature23470 (2017).
69 Gluck, S. et al. Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence. Nat Cell Biol 19, 1061-1070, doi:10.1038/ncb3586 (2017).
70 Sekine, K., Kubo, K. & Nakajima, K. How does Reelin control neuronal migration and layer formation in the developing mammalian neocortex? Neurosci Res 86, 50-58, doi:10.1016/j.neures.2014.06.004 (2014).
71 Loncle, N., Agromayor, M., Martin-Serrano, J. & Williams, D. W. An ESCRT module is required for neuron pruning. Sci Rep 5, 8461, doi:10.1038/srep08461 (2015).
72 Gong, Y. N. et al. ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences. Cell 169, 286-300 e216, doi:10.1016/j.cell.2017.03.020 (2017).
73 Claude-Taupin, A. et al. ATG9A protects the plasma membrane from programmed and incidental permeabilization. Nat Cell Biol 23, 846-858, doi:10.1038/s41556-021-00706-w (2021).
74 Martini-Stoica, H., Xu, Y., Ballabio, A. & Zheng, H. The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective. Trends Neurosci 39, 221- 234, doi:10.1016/j.tins.2016.02.002 (2016).
75 Pastore, N. et al. TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages. Autophagy 12, 1240-1258, doi:10.1080/15548627.2016.1179405 (2016).
76 Ponpuak, M. et al. Secretory autophagy. Curr Opin Cell Biol 35, 106-116, doi:10.1016/j.ceb.2015.04.016 (2015).
77 Ejlerskov, P. et al. Tubulin polymerization-promoting protein (TPPP/p25alpha) promotes unconventional secretion of alpha-synuclein through exophagy by impairing autophagosome-lysosome fusion. J Biol Chem 288, 17313-17335, doi:10.1074/jbc.M112.401174 (2013).
78 Gui, X. et al. Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature 567, 262-266, doi:10.1038/s41586-019- 1006-9 (2019).
79 Dupont, N. et al. Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1beta. EMBO J 30, 4701-4711, doi:10.1038/emboj.2011.398 (2011).
80 Hayakawa, K. et al. Transfer of mitochondria from astrocytes to neurons after stroke. Nature 535, 551-555, doi:10.1038/nature18928 (2016).
81 Joshi, A. U. et al. Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nat Neurosci 22, 1635-1648, doi:10.1038/s41593-019-0486-0 (2019).
82 Budnik, V., Ruiz-Canada, C. & Wendler, F. Extracellular vesicles round off communication in the nervous system. Nat Rev Neurosci 17, 160-172, doi:10.1038/nrn.2015.29 (2016).
83 Asai, H. et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci 18, 1584-1593, doi:10.1038/nn.4132 (2015).
84 Yokoi, A. et al. Mechanisms of nuclear content loading to exosomes. Sci Adv 5, eaax8849, doi:10.1126/sciadv.aax8849 (2019).
85 Goldmann, T. et al. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat Immunol 17, 797-805, doi:10.1038/ni.3423 (2016).
86 Utz, S. G. et al. Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development. Cell 181, 557-573 e518, doi:10.1016/j.cell.2020.03.021 (2020).
87 Bialas, A. R. et al. Microglia-dependent synapse loss in type I interferon- mediated lupus.
88 Mackenzie, K. J. et al. cGAS surveillance of micronuclei links genome instability to innate immunity. Nature 548, 461-465, doi:10.1038/nature23449 (2017)
89 Bialas, A. R. et al. Microglia-dependent synapse loss in type I interferon- mediated lupus. Nature 546, 539-543, doi:10.1038/nature22821 (2017).
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