Amano H, Fukuda Y, Yokoo T, Yamaoka K. (2018) Interleukin-6 level among shift and night workers in Japan: Cross-sectional analysis of the J-HOPE study. J Atheroscler Thromb. 25:1206-14
Asai Y, Sano H, Miyazaki M, Iwakura M, Maeda Y, Hara M. (2019) Suvorexant (Belsomra® tablets 10, 15, and 20 mg): Japanese drug-use results survey. Drugs R D. 19:27-46
Betschart C, Hintermann S, Behnke D, Cotesta S, Fendt M, Gee CE, Jacobson LH, Laue G, Ofner S, Chaudhari V, Badiger S, Pandit C, Wagner J, Hoyer D. (2013) Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia. J Med Chem. 56:7590-607
Bonaz B, Sinniger V, Pellissier S. (2016) Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation. J Physiol. 594:5781-90
Born S, Gauvin DV, Mukherjee S, Briscoe R. (2017) Preclinical assessment of the abuse potential of the orexin receptor antagonist, suvorexant. Regul Toxicol Pharmacol. 86:181-92
Castro-Diehl C, Diez Roux AV, Redline S, Seeman T, McKinley P, Sloan R, Shea S. (2016) Sleep duration and quality in relation to autonomic nervous system measures: the multi-ethnic study of atherosclerosis (MESA). Sleep. 39:1927-40
Van Cauter E, Spiegel K, Tasali E, Leproult R. (2008) Metabolic consequences of sleep and sleep loss. Sleep Med. 9:S23-8
Chaput JP, Després JP, Bouchard C, Tremblay A. (2008) The association between sleep duration and weight gain in adults: a 6-year prospective study from the Quebec Family Study. Sleep. 31:517-23
Cox CD, Breslin MJ, Whitman DB, Schreier JD, McGaughey GB, Bogusky MJ, Roecker AJ, Mercer SP, Bednar RA, Lemaire W, Bruno JG, Reiss DR, Harrell CM, Murphy KL, Garson SL, Doran SM, Prueksaritanont T, Anderson WB, Tang C, Roller S, Cabalu TD, Cui D, Hartman GD, Young SD, Koblan KS, Winrow CJ, Renger JJ, Coleman PJ. (2010) Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia. J Med Chem. 53:5320-32
Dorheim SK, Bondevik GT, Eberhard-Gran M, Bjorvatn B. (2009) Sleep and depression in postpartum women: a population-based study. Sleep. 32:847-55
Etori K, Saito YC, Tsujino N, Sakurai T. (2014) Effects of a newly develped potent orexin-2 receptor-selective antagonist, compound 1m, on sleep/wakefulness states in mice. Front Neurosci. 8:8
Fan Y, Jiang E, Hahka T, Chen QH, Yan J, Shan Z. (2018) Orexin A increases sympathetic nerve activity through promoting expression of proinflammatory cytokines in Sprague Dawley rats. Acta Physiologica. 222:e13011
Fox SV, Gotter AL, Tye SJ, Garson SL, Savitz AT, Uslaner JM, Brunner JI, Tannenbaum PL, McDonald TP, Hodgson R, Yao L, Bowlby MR, Kuduk SD, Coleman PJ, Hargreaves R, Winrow CJ, Renger JJ. (2013) Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats. Neuropsychopharmacology. 38:2401-8
Goncalves AC, Tank J, Diedrich A, Hilzendeger A, Plehm R, Bader M, Luft FC, Jordan J, Gross V. (2009) Diabetic hypertensive leptin receptor-deficient db/db mice develop cardioregulatory autonomic dysfunction. Hypertension. 53:387-92
Gotter AL, Webber AL, Coleman PJ, Renger JJ, Winrow CJ. (2012) International union of basic and clinical pharmacology. LXXXVI. Orexin receptor function, nomenclature and pharmacology. Pharmacol Rev. 64:389-420
Gotter AL, Roecker AJ, Hargreaves R, Coleman PJ, Winrow CJ, Renger JJ. (2012) Orexin receptors as therapeutic drug targets. Prog Brain Res. 198:163-88
Gotter AL, Forman MS, Harrell CM, Stevens J, Svetnik V, Yee KL, Li X, Roecker AJ, Fox SV, Tannenbaum PL, Garson SL, Lepeleire ID, Calder N, Rosen L, Struyk A, Coleman PJ, Herring WJ, Renger JJ, Winrow CJ. (2016) Orexin 2 receptor antagonism is sufficient to promote NREM and REM sleep from mouse to man. Sci Rep. 6:27147
Gottlieb DJ, Punjabi NM, Newman AB, Resnick HE, Redline S, Baldwin CM, Nieto FJ. (2005) Association of sleep time with diabetes mellitus and impaired glucose tolerance. Intern Med. 165:863-7
Gottlieb DJ, Redline S, Nieto FJ, Baldwin CM, Newman AB, Resnick HE, Punjabi NM. (2006) Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep. 29:1009-14
Guarino D, Nannipieri M, Iervasi G, Taddei S, Bruno RM. (2017) The role of the autonomic nervous system in the pathophysiology of obesity. Front Physiol. 8:665
Hall MH, Muldoon MF, Jennings JR, Buysse DJ, Flory JD, Manuck SB. (2008) Self-reported sleep duration is associated with the metabolic syndrome in midlife adults. Sleep. 31:635-43
Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M. (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc Natl Acad Sci U S A. 114:5731-6
Irwin MR, Wang M, Campomayor CO, Collado-Hidalgo A, Cole S. (2006) Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch Intern Med. 166:1756-62
Irwin MR, Olmstead R, Carrillo C, Sadeghi N, Breen EC, Witarama T, Yokomizo M, Lavretsky H, Carroll JE, Motivala SJ, Bootzin R, Nicassio P. (2014) Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep. 37:1543-52
Irwin MR, Olmstead R, Carroll JE (2016) Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 80:40-52
Jackson KL, Dampney BW, Moretti JL, Stevenson ER, Davern PJ, Carrive P, Head GA. (2016) Contribution of orexin to the neurogenic hypertension in BPH/2J mice. Hypertension. 67:959-69
Kaczmarek P, Skrzypski M, Pruszynska-Oszmalek E, Sassek M, Kolodziejski PA, Billert M, Szczepankiewicz D, Wojciechowicz T, Maechler P, Nowak KW, Strowski MZ. (2017) Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions. J Physiol Pharmacol. 68:669-81
Lan F, Misu H, Chikamoto K, Takayama H, Kikuchi A, Mohri K, Takata N, Hayashi H, Matsuzawa-Nagata N, Takeshita Y, Noda H, Matsumoto Y, Ota T, Nagano T, Nakagen M, Miyamoto K, Takatsuki K, Seo T, Iwayama K, Tokuyama K, Matsugo S, Tang H, Saito Y, Yamagoe S, Kaneko S, Takamura T. (2014) LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. Diabetes. 63:1649-64
Laposky AD, Bradley MA, Williams DL, Bass J, Turek FW. (2008) Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice. Am J Physiol Regul Integr Comp Physiol. 295:R2059-66
Lee SWH, Ng KY, Chin WK. (2017) The impact of sleep amount and sleep quality on glycemic control in type 2 diabetes: A systematic review and meta-analysis. Sleep Med Rev. 31:91-101
Lewis PA, Knoblich G, Poe G. (2018) How memory replay in sleep boosts creative problem solving. Trends Cogn Sci. 22:491-503
Mayoral Monibas R, Johnson AM, Osborn O, Traves PG, Mahata SK. (2016) Distinct hepatic macrophage populations in lean and obese mice. Front Endocrinol. 7:152
Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM. (2004) Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 43:678-83
Minehira D, Takahara S, Adachi I, Toyooka N. (2014) Laboratory and practical synthesis of suvorexant, a selective dual orexin receptor antagonist. Tetrahedron Lett. 55:5778-80
Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, Kurita S, Ishikura K, Ando H, Takeshita Y, Ota T, Sakurai M, Yamashita T, Mizukoshi E, Yamashita T, Honda M, Miyamoto K, Kubota T, Kubota N, Kadowaki T, Kim HJ, Lee IK, Minokoshi Y, Saito Y, Takahashi K, Yamada Y, Takakura N, Kaneko S. (2010) A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 12:483-95
Nedeltcheva AV, Kessler L, Imperial J, Penev PD. (2009) Exposure to recurrent sleep restriction in the setting of high caloric intake and physical inactivity results in increased insulin resistance and reduced glucose tolerance. J Clin Endocrinol Metab. 94:3242-50
Ohkuma T, Fujii H, Iwase M, Kikuchi Y, Ogata S, Idewaki Y, Ide H, Doi Y, Hirakawa Y, Nakamura U, Kitazono T. (2013) Impact of sleep duration on obesity and the glycemic level in patients with type 2 diabetes: the Fukuoka Diabetes Registry. Diabetes care. 36:611-7
Park JH, Shim HM, Na AY, Bae JH, Im SS, Song DK. (2015) Orexin A regulates plasma insulin and leptin levels in a time-dependent manner following a glucose load in mice. Diabetologia. 58:1542-50
Qi D, Rodrigues B. (2007) Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism. Am J Physiol Endocrinol Metab. 292:E654-67
Qian J, Scheer FAJL. (2016) Circadian system and glucose metabolism: Implications for physiology and disease. Trends Endocrinol Metab. 27:282-93
Ramirez AD, Gotter AL, Fox SV, Tannenbaum PL, Yao L, Tye SJ, McDonald T, Brunner J, Garson SL, Reiss DR, Kuduk SD, Coleman PJ, Uslaner JM, Hodgson R, Browne SE, Renger JJ, Winrow CJ. (2013) Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators. Front Neurosci. 7:254
Rhyne DN, Anderson SL. (2015) Suvorexant in insomnia: efficacy, safety and place in therapy. Ther Adv Drug Saf. 6:189-95
Ross LE, McLean LM. (2006) Anxiety disorders during pregnancy and the postpartum period: a systematic review. J Clin Psychiatry. 67:1285-98
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 92:573-85
Saxton SN, Withers SB, Heagerty AM. (2019) Emerging roles of sympathetic nerves and inflammation in perivascular adipose tissue. Cardiovasc Drugs Ther. 33:245-59
Schwartz MW, Seeley RJ, Tschöp MH, Woods SC, Morton GJ, Myers MG, D'Alessio D. (2013) Cooperation between brain and islet in glucose homeostasis and diabetes. Nature. 503:59-66
Senador D, Kanakamedala K, Irigoyen MC, Morris M, Elased KM. (2009) Cardiovascular and autonomic phenotype of db/db diabetic mice. Exp Physiol. 94:648-58
Spiegel K, Sheridan JF, Van Cauter E. (2002) Effect of sleep deprivation on response to immunization. JAMA. 288:1471-2
Stranges S, Dorn JM, Cappuccio FP, Donahue RP, Rafalson LB, Hovey KM, Freudenheim JL, Kandala NB, Miller MA, Trevisan M. (2010) A population-based study of reduced sleep duration and hypertension: the strongest association may be in premenopausal women. J Hypertens. 28:896-902
Strawn JR, Pyne-Geithman GJ, Ekhator NN, Horn PS, Uhde TW, Shutter LA, Baker DG, Geracioti TD Jr. (2010) Low cerebrospinal fluid and plasma orexin-A (hypocretin-1) concentrations in combat-related posttraumatic stress disorder. Psychoneuroendocrinology. 35:1001-7
Stump CA, Cooke AJ, Bruno J, Cabalu TD, Gotter AL, Harell CM, Kuduk SD, McDonald TP, O'Brien J, Renger JJ, Williams PD, Winrow CJ, Coleman PJ. (2016) Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology. Bioorg Med Chem Lett. 26:5809-14
Szabo ST, Thorpy MJ, Mayer G, Peever JH, Kilduff TS. (2019) Neurobiological and immunogenetic aspects of narcolepsy: Implications for pharmacotherapy. Sleep Med Rev. 43:23-36
Taheri S, Lin L, Austin D, Young T, Mignot E. (2004) Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 3:e62
Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. (2018) Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 24:1058-69
Tasali E, Leproult R, Ehrmann DA, Van Cauter E. (2008) Slow-wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci U S A. 105:1044-9
Tannenbaum PL, Tye SJ, Stevens J, Gotter AL, Fox SV, Savitz AT, Coleman PJ, Uslaner JM, Kuduk SD, Hargreaves R, Winrow CJ, Renger JJ. (2016) Inhibition of orexin signaling promotes sleep yet preserves salient arousability in monkeys. Sleep. 39:603-12
Tsujino N, Sakurai T. (2009) Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev. 61:162-76
Tsujino N, Sakurai T. (2013) Role of orexin in modulating arousal, feeding, and motivation. Front Behav Neurosci. 7:28
Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka T. (2016) Timed inhibition of orexin system by suvorexant improved sleep and glucose metabolism in type 2 diabetic db/db mice. Endocrinology. 157:4146-57
Tsuneki H, Wada T, Sasaoka T. (2018) Chronopathophysiological implications of orexin in sleep disturbances and lifestyle-related disorders. Pharmacol Ther. 186:25-44
Xiao F, Jiang M, Du D, Xia C, Wang J, Cao Y, Shen L, Zhu D. (2013) Orexin A regulates cardiovascular responses in stress-induced hypertensive rats. Neuropharmacology. 67:16-24
Zarifkar M, Noshad S, Shahriari M, Afarideh M, Khajeh E, Karimi Z, Ghajar A, Esteghamati A. (2017) Inverse association of peripheral orexin-A with insulin resistance in type 2 diabetes mellitus: A randomized clinical trial. Rev Diabet Stud. 14:301-10
Zhu B, Shi C, Park CG, Zhao X, Reutrakul S. (2019) Effects of sleep restriction on metabolism-related parameters in healthy adults: A comprehensive review and meta-analysis of randomized controlled trials. Sleep Med Rev. 45:18-30
厚生労働省 平成 28 年「国民健康・栄養調査」
宮本雅之. (2018) 睡眠医療 (ライフ・サイエンス社). 48: 73-78
日本糖尿病学会 糖尿病診療ガイドライン 2019