Studies on Natural Products from Untapped Bacterial Resources [an abstract of entire text]

概要

Introduction
Natural product (NP) and its derivatives have made a major contribution to drug discovery and development. Thousands of NPs have been clinically approved to treat various human diseases. However, new therapeutic agents are still required to treat cancer and infectious diseases. In addition, recent exploration of novel NPs is challenged by high-rate rediscovery of previously reported molecules. On the other hand, metagenomic analysis of many marine invertebrates and soil ecosystems revealed enormous of biosynthetic gene clusters (BGCs) encoded for new bioactive small molecules. Furthermore, these potential BGCs are associated with diverse and rare bacteria that have never been investigated before. Thus, targeting these untapped microbial strains from marine and soil ecosystems would lead to discovery of novel natural products. This study covered explorations of novel NPs from untapped and rare bacterial strains living in marine invertebrates and soil ecosystem.

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