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大学・研究所にある論文を検索できる 「Oral caffeine intake amplifies the effect of isoproterenol in patients with frequent premature ventricular contractions」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Oral caffeine intake amplifies the effect of isoproterenol in patients with frequent premature ventricular contractions

長谷部, 秀幸 筑波大学 DOI:10.15068/0002000733

2021.07.28

概要

Aims: Infrequent appearance and failed induction of premature ventricular contractions (PVCs) at catheter ablation make their localization difficult and are associated with a poor procedural outcome. This study aimed to assess the effect of preprocedural oral caffeine intake on induction of PVCs during catheter ablation.

Methods: Seventy patients (age: 54 ± 14 years, 37 men) undergoing catheter ablation for monofocal PVCs were randomized to receive oral caffeine (5 mg/kg）or placebo. Before ablation, PVC counts for 5 min were performed at baseline and during isoproterenol infusion and the isoproterenol washout period. PVC count fluctuation was defined as the difference between the highest and lowest 5-min count among the three time periods.

Results: The 5-min PVC counts during baseline and isoproterenol infusion were equivalent between the groups. However, those during the isoproterenol washout period and PVC count fluctuation were significantly higher in the caffeine group than the control group (73.1 ± 73.2 vs. 38.9 ± 28.9 beats/5 min, P = .012 and 69.3 ± 61.3 vs. 37.7 ± 30.9 beats/5 min, P = .008, respectively). The procedure and ablation times were significantly shorter in the caffeine group than the control group (105.0 ± 23.4 vs. 136.9 ± 43.2 min, P < .01 and 219.1 ± 104.7 vs. 283.5 ± 136.0 sec, P < .01, respectively).

Conclusions: Oral caffeine intake amplified the effect of isoproterenol infusion on PVC induction during catheter ablation. The combined use of oral caffeine intake and isoproterenol infusion can be an option to increase intraprocedural PVCs.

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参考文献

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