Ahlqvist KJ, Hämäläinen RH, Yatsuga S, Uutela M, Terzioglu M, Götz A, Forsström S, Salven P, Angers-Loustau A, Kopra OH, Tyynismaa H, Larsson NG, Wartiovaara K, Prolla T, Trifunovic A, Suomalainen A. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metab. vol. 15, pp. 100-109, 2012.
Akiguchi I, Pallàs M, Budka H, Akiyama H, Ueno M, Han J, Yagi H, Nishikawa T, Chiba Y, Sugiyama H, Takahashi R, Unno K, Higuchi K, Hosokawa M. SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions. Neuropathology. vol. 37, pp. 293-305, 2017.
Amaral DG, Witter MP. The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience. vol. 31, pp. 571-591, 1989.
Ball MJ. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta Neuropathol. vol. 37, pp. 111-118, 1977.
Barnes CA. Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol. vol. 93, pp. 74-104, 1979.
Berridge MJ, Bootman MD, Lipp P. Calcium--a life and death signal. Nature. vol. 395, pp. 645-648, 1998.
Bliss TV, Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol. vol. 232, pp. 331-356, 1979.
Brose N, Petrenko AG, Südhof TC, Jahn R. Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science. vol. 256, pp. 1021-1025, 1992.
Burgess A, Wainwright SR, Shihabuddin LS, Rutishauser U, Seki T, Aubert I. Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus. Dev Neurobiol. vol. 68, pp. 1580-1590, 2008.
Buzsáki G. Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning. Hippocampus. vol. 25, pp. 1073-1188, 2015.
Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet. vol. 36, pp. 877-882, 2004.
Choi DW. Excitotoxic cell death. J Neurobiol. vol. 23, pp. 1261-1276, 1992.
Churchill JD, Stanis JJ, Press C, Kushelev M, Greenough WT. Is procedural memory relatively spared from age effects? Neurobiol Aging. vol. 24, pp. 883-892, 2003.
Clayton NS, Dickinson A. Episodic-like memory during cache recovery by scrub jays. Nature. vol. 395, pp. 272-274, 1998.
Coleman PD, Flood DG. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging. vol. 8, pp. 521-545, 1987.
Cremer H, Lange R, Christoph A, Plomann M, Vopper G, Roes J, Brown R, Baldwin S, Kraemer P, Scheff S, Barthels D, Rajewsky K, Wille W. Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature. vol. 367, pp. 455-459, 1994.
Daselaar SM, Fleck MS, Dobbins IG, Madden DJ, Cabeza R. Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study. Cereb Cortex. vol. 16, pp. 1771-1782, 2006.
del Valle J, Bayod S, Camins A, Beas-Zárate C, Velázquez-Zamora DA, González-Burgos I, Pallàs M. Dendritic spine abnormalities in hippocampal CA1 pyramidal neurons underlying memory deficits in the SAMP8 mouse model of Alzheimer's disease. J Alzheimers Dis. vol. 32, pp. 233-240, 2012.
Dere E, Huston JP, De Souza Silva MA. Episodic-like memory in mice: simultaneous assessment of object, place and temporal order memory. Brain Res Brain Res Protoc. vol. 16, pp. 10-19, 2005.
Dere E, Kart-Teke E, Huston JP, De Souza Silva MA. The case for episodic memory in animals. Neurosci Biobehav Rev. vol. 30, pp. 1206-1224, 2006.
Dierckx E, Engelborghs S, De Raedt R, De Deyn PP, D'Haenens E, Verte D, Ponjaert-Kristoffersen I. The 10-word learning task in the differential diagnosis of early Alzheimer's disease and elderly depression: A cross-sectional pilot study. Aging Ment Health. vol. 15, pp. 113-121, 2011.
Dityatev A, Dityateva G, Sytnyk V, Delling M, Toni N, Nikonenko I, Muller D, Schachner M. Polysialylated neural cell adhesion molecule promotes remodeling and formation of
Düzel E, Vargha-Khadem F, Heinze HJ, Mishkin M. Brain activity evidence for recognition without recollection after early hippocampal damage. Proc Natl Acad Sci U S A. vol. 98, pp. 8101-8106, 2001.
Eckhardt M, Bukalo O, Chazal G, Wang L, Goridis C, Schachner M, Gerardy-Schahn R, Cremer H, Dityatev A. Mice deficient in the polysialyltransferase ST8SiaIV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity. J Neurosci. vol. 20, pp. 5234-5244, 2000.
Eckles-Smith K, Clayton D, Bickford P, Browning MD. Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression. Brain Res Mol Brain Res. vol. 78, pp. 154-162, 2000.
Féart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, Scarmeas N, Barberger-Gateau P. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. vol. 302, pp. 638-648, 2009.
Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG. A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria. Science. vol. 11, pp. 1621-1623, 2006.
Foster TC. Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity. Prog Neurobiol. vol. 96, pp. 283-303, 2012.
Gallagher M, Landfield PW, McEwen B, Meaney MJ, Rapp PR, Sapolsky R, West MJ. Hippocampal neurodegeneration in aging. Science. vol. 274, pp. 484-485, 1996.
Gannon OJ, Robison LS, Custozzo AJ, Zuloaga KL. Sex differences in risk factors for vascular contributions to cognitive impairment & dementia. Neurochem Int. S0197-0186(18)30511-4., 2018.
Gottesman RF, Schneider AL, Albert M, Alonso A, Bandeen-Roche K, Coker L, Coresh J, Knopman D, Power MC, Rawlings A, Sharrett AR, Wruck LM, Mosley TH. Midlife hypertension and 20-year cognitive change: the atherosclerosis risk in communities neurocognitive study. JAMA Neurol. vol. 71, pp. 1218-1227, 2014.
Gutchess AH, Welsh RC, Hedden T, Bangert A, Minear M, Liu LL, Park DC. Aging and the neural correlates of successful picture encoding: frontal activations compensate for decreased medial-temporal activity. J Cogn Neurosci. vol. 17, pp. 84-96, 2005.
Hebb, DO. The Organization of Behavior: A Neuropsychological Theory. J Comp Physiol Psychol. vol. 42, pp. 192-206, 1949.
Heilbronn LK, Ravussin E. Calorie restriction and aging: review of the literature and implications for studies in humans. Am J Clin Nutr. vol. 78, pp. 361-369, 2003.
Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. vol. 85, pp. 1694-1704, 2004.
Hildebrandt H, Mühlenhoff M, Weinhold B, Gerardy-Schahn R. Dissecting polysialic acid and NCAM functions in brain development. J Neurochem. vol. 103 (Suppl 1), pp. 56-64, 2007.
Ito K, Contractor A, Swanson GT. Attenuated plasticity of postsynaptic kainate receptors in hippocampal CA3 pyramidal neurons. J Neurosci. vol. 24, pp. 6228-6236, 2004.
Jack CR Jr, Petersen RC, Xu Y, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF, Tangalos EG, Kokmen E. Rates of hippocampal atrophy correlate with change in clinical status in aging and AD. Neurology. vol. 55, pp. 484-489, 2000.
Jarrard LE. On the role of the hippocampus in learning and memory in the rat. Behav Neural Biol. vol. 60, pp. 9-26, 1993.
Kalmijn S, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Ann Neurol. vol. 42, pp. 776-782, 1997.
Kennedy KM, Raz N. Aging white matter and cognition: differential effects of regional variations in diffusion properties on memory, executive functions, and speed. Neuropsychologia. vol. 47, pp. 916-927, 2009.
Kikusui T, Shimozawa A, Kitagawa A, Nagasawa M, Mogi K, Yagi S, Shiota K. N-acetylmannosamine improves object recognition and hippocampal cell proliferation in middle-aged mice. Biosci Biotechnol Biochem. vol. 76, pp. 2249-2254, 2012.
Kitamura T, Ogawa SK, Roy DS, Okuyama T, Morrissey MD, Smith LM, Redondo RL, Tonegawa S. Engrams and circuits crucial for systems consolidation of a memory. Science. vol. 356, pp. 73-78, 2017.
Kontou M, Bauer C, Reutter W, Horstkorte R. Sialic acid metabolism is involved in the regulation of gene expression during neuronal differentiation of PC12 cells. Glycoconj J. vol. 25, pp. 237-244, 2008.
Kukolja J, Thiel CM, Wilms M, Mirzazade S, Fink GR. Ageing-related changes of neural activity associated with spatial contextual memory. Neurobiol Aging. vol. 30, pp. 630-345, 2009.
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. vol. 390, pp. 45-51, 1997.
Landfield PW, Pitler TA. Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats. Science. vol. 226, pp. 1089-1092, 1984.
Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, Kukull W. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med. vol. 144, pp. 73-81, 2006.
Lechner HA, Squire LR, Byrne JH. 100 years of consolidation--remembering Müller and Pilzecker. Learn Mem. vol. 6, pp. 77-87, 1999.
Li Q, Vo HT, Wang J, Fox-Quick S, Dobrunz LE, King GD. Klotho regulates CA1 hippocampal synaptic plasticity. Neuroscience. vol. 347, pp. 123-133, 2017.
Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K, Tonegawa S. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature. vol. 484, pp. 381-385, 2012.
Lombard DB, Beard C, Johnson B, Marciniak RA, Dausman J, Bronson R, Buhlmann JE, Lipman R, Curry R, Sharpe A, Jaenisch R, Guarente L. Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol. vol. 20, pp. 3286-3291, 2000.
Lustig C, Buckner RL. Preserved neural correlates of priming in old age and dementia. Neuron. vol. 42, pp. 865-875, 2004.
Lynch G, Larson J, Kelso S, Barrionuevo G, Schottler F. Intracellular injections of EGTA block induction of hippocampal long-term potentiation. Nature. vol. 305, pp. 719-721, 1983.
Maguire EA, Vargha-Khadem F, Mishkin M. The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval. Brain. vol. 124, pp. 1156-1170, 2001.
McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition. vol. 5, pp. 155-171, discussion 172, 1989.
McDaniel MA, Maier SF, Einstein GO. "Brain-specific" nutrients: a memory cure? Nutrition. vol. 19, pp. 957-975, 2003.
McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science. vol. 317, pp. 94-99, 2007.
McNaughton BL, Barnes CA, Rao G, Baldwin J, Rasmussen M. Long-term enhancement of hippocampal synaptic transmission and the acquisition of spatial information. J Neurosci. vol. 6, pp. 563-571, 1986.
Messier C, Awad N, Gagnon M. The relationships between atherosclerosis, heart disease, type 2 diabetes and dementia. Neurol Res. vol. 26, pp. 567-572, 2004.
Mitchell DB, Brown AS, Murphy DR. Dissociations between procedural and episodic memory: effects of time and aging. Psychol Aging. vol. 5, pp. 264-276, 1990.
Mitchell SJ, Scheibye-Knudsen M, Longo DL, de Cabo R. Animal models of aging research: implications for human aging and age-related diseases. Annu Rev Anim Biosci. vol. 3, pp. 283-303, 2015.
Moffat SD, Elkins W, Resnick SM. Age differences in the neural systems supporting human allocentric spatial navigation. Neurobiol Aging. vol. 27, pp. 965-972, 2006.
Morris RG, Anderson E, Lynch GS, Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature. vol. 319, pp. 774-776, 1986.
Mungas D, Beckett L, Harvey D, Farias ST, Reed B, Carmichael O, Olichney J, Miller J, DeCarli C. Heterogeneity of cognitive trajectories in diverse older persons. Psychol Aging. vol. 25, pp. 606-619, 2010.
Nabavi S, Fox R, Proulx CD, Lin JY, Tsien RY, Malinow R. Engineering a memory with LTD and LTP. Nature. vol. 511, pp. 348-352, 2014.
Nagasawa M, Shimozawa A, Mogi K, Kikusui T. N-acetyl-D-mannosamine treatment alleviates age-related decline in place-learning ability in dogs. J Vet Med Sci. vol. 76, pp. 757-761, 2014.
Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, Tonegawa S. Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell. vol. 149, pp. 188-201, 2012.
Naveh-Benjamin M. Adult age differences in memory performance: tests of an associative deficit hypothesis. J Exp Psychol Learn Mem Cogn. vol. 26, pp. 1170-1187, 2000.
O’Callaghan RM, Griffin EW, Kelly AM. Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus. Hippocampus. vol. 19, pp. 1019-1029, 2009.
Olton DS, Walker JA, Gage FH. Hippocampal connections and spatial discrimination. Brain Res. vol. 139, pp. 295-308, 1978.
Orozco Arbelaez E, Banegas JR, Rodríguez Artalejo F, López García E. Influence of habitual chocolate consumption over the Mini-Mental State Examination in Spanish older adults. Nutr Hosp. vol. 34, pp. 841-846, 2017.
Plancher G, Gyselinck V, Nicolas S, Piolino P. Age effect on components of episodic memory and feature binding: A virtual reality study. Neuropsychology. vol. 24, pp. 379-390, 2010.
Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C. What is memory? The present state of the engram. BMC Biol. vol. 14, 40, 2016
Posner HB, Tang MX, Luchsinger J, Lantigua R, Stern Y, Mayeux R. The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. Neurology. vol. 58, pp. 1175-1181, 2002.
Press GA, Amaral DG, Squire LR. Hippocampal abnormalities in amnesic patients revealed by high-resolution magnetic resonance imaging. Nature. vol. 341, pp. 54-57, 1989.
Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. vol. 4, pp. 487-499, 2005.
Rasmussen T, Schliemann T, Sørensen JC, Zimmer J, West MJ. Memory impaired aged rats: no loss of principal hippocampal and subicular neurons. Neurobiol Aging. vol. 17, pp. 143-147, 1996.
Raz N, Gunning FM, Head D, Dupuis JH, McQuain J, Briggs SD, Loken WJ, Thornton AE, Acker JD. Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex. vol. 7, pp. 268-282, 1997.
Reijmers LG, Perkins BL, Matsuo N, Mayford M. Localization of a stable neural correlate of associative memory. Science. vol. 317, pp. 1230-1233, 2007.
Scoville WB, Milner B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. vol. 20, pp. 11-21, 1957.
Senkov O, Sun M, Weinhold B, Gerardy-Schahn R, Schachner M, Dityatev A. Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning paradigm. J Neurosci. vol. 26, pp. 10888-10898, 2006.
Sharps MJ, Gollin ES. Memory for object locations in young and elderly adults. J Gerontol. vol. 42, pp. 336-341, 1987.
Shimada A, Keino H, Satoh M, Kishikawa M, Hosokawa M. Age-related loss of synapses in the frontal cortex of SAMP10 mouse: a model of cerebral degeneration. Synapse. vol. 48, pp. 198-204, 2003.
Shimada A, Tsuzuki M, Keino H, Satoh M, Chiba Y, Saitoh Y, Hosokawa M. Apical vulnerability to dendritic retraction in prefrontal neurones of ageing SAMP10 mouse: a model of cerebral degeneration. Neuropathol Appl Neurobiol. vol. 32, pp. 1-14, 2006.
Skoog I. Status of risk factors for vascular dementia. Neuroepidemiology. vol. 17, pp. 2-9, 1998. Smith ML, Milner B. The role of the right hippocampus in the recall of spatial location. Neuropsychologia. vol. 19, pp. 781-793, 1981.
Smith ML, Milner B. Differential effects of frontal-lobe lesions on cognitive estimation and spatial memory. Neuropsychologia. vol. 22, pp. 697-705, 1984.
Squire LR, Amaral DG, Press GA. Magnetic resonance imaging of the hippocampal formation and mammillary nuclei distinguish medial temporal lobe and diencephalic amnesia. J Neurosci. vo. 10, pp. 3106-3117, 1990.
Squire LR, Zola SM. Structure and function of declarative and nondeclarative memory systems. Proc Natl Acad Sci U S A. vol. 93, pp. 13515-13522, 1996.
Squire LR, Zola SM. The medial temporal lobe memory system. Science. vol. 253, pp. 1380-1386, 1991.
Takeda T. Senescence-accelerated mouse (SAM): a biogerontological resource in aging research. Neurobiol Aging. vol. 20, pp. 105-110, 1999.
Takeda T. Senescence-accelerated mouse (SAM) with special references to neurodegeneration models, SAMP8 and SAMP10 mice. Neurochem Res. vol. 34, pp. 639-659, 2009.
Takeda T, Hosokawa M, Takeshita S, Irino M, Higuchi K, Matsushita T, Tomita Y, Yasuhira K, Hamamoto H, Shimizu K, Ishii M, Yamamuro T. A new murine model of accelerated senescence. Mech Ageing Dev. vol. 17, pp. 183-194, 1981.
Tanaka Y, Han H, Hagishita T, Fukui F, Liu G, Ando S. alpha-Sialylcholesterol enhances the depolarization-induced release of acetylcholine and glutamate in rat hippocampus: in vivo microdialysis study. Neurosci Lett. vol. 357, pp. 9-12, 2004.
Thibault O, Landfield PW. Increase in single L-type calcium channels in hippocampal neurons during aging. Science. vol. 272, pp. 1017-1020, 1996.
Toescu EC, Vreugdenhil M. Calcium and normal brain ageing. Cell Calcium. vol. 47, pp. 158-164, 2010.
Tonegawa S, Liu X, Ramirez S, Redondo R. Memory Engram Cells Have Come of Age. Neuron. vol. 87, pp. 918-931, 2015.
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly-Y M, Gidlöf S, Oldfors A, Wibom R, Törnell J, Jacobs HT, Larsson NG. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. vol. 429, pp. 417-423, 2004.
Tulving E. Episodic and semantic memory. In E. Tulving & W. Donaldson (Eds.), Organization of memory. pp.382-403, 1972.
Tulving E. Elements of episodic memory. New York: Oxford University Press., 1983 Tulving E. Episodic memory: from mind to brain. Annu Rev Psychol. vol. 53pp. 1-25, 2002.
Unno K, Takabayashi F, Kishido T, Oku N. Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10). Exp Gerontol. vol. 39, pp. 1027-1034, 2004.
Varga R, Eriksson M, Erdos MR, Olive M, Harten I, Kolodgie F, Capell BC, Cheng J, Faddah D, Perkins S, Avallone H, San H, Qu X, Ganesh S, Gordon LB, Virmani R, Wight TN, Nabel EG, Collins FS. Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A. vol. 103, pp. 3250-3255, 2003.
Vargha-Khadem F, Gadian DG, Watkins KE, Connelly A, Van Paesschen W, Mishkin M. Differential effects of early hippocampal pathology on episodic and semantic memory. Science. vol. 277, pp. 376-380, 1997.
Waite LM. Treatment for Alzheimer's disease: has anything changed? Aust Prescr. vol. 38, pp. 60-63, 2015.
West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet. vol. 344, pp. 769-772, 1994.
Winocur G, Moscovitch M, Rosenbaum RS, Sekeres M. A study of remote spatial memory in aged rats. Neurobiol Aging. vol. 31, pp. 143-150, 2010.
Winocur G. A neuropsychological analysis of memory loss with age. Neurobiol Aging. vol. 9, pp. 487-494, 1988.
Yang SH, Meta M, Qiao X, Frost D, Bauch J, Coffinier C, Majumdar S, Bergo MO, Young SG, Fong LG. A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation. J Clin Invest. vol. 116, pp. 2115-2121, 2006.
Zola-Morgan S, Squire LR, Amaral DG. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J Neurosci. vol. 6, pp. 2950-2967, 1986.
Zornetzer SF, Thompson R, Rogers J. Rapid forgetting in aged rats. Behav Neural Biol. vol. 36, pp. 49-60, 1982.
小原知之、二宮利治、神庭重信、清原裕生活習慣病と認知症:久山町研究老年期認知症研究会誌vol.19, pp.54-57,2012.
厚生労働省。平成28年度国民生活基礎調査2017.
厚生労働省。平成29年国民健康・栄養調査報告2018.
厚生労働省。平成30年度版高齢社会白書2018.
佐藤暢哉。ヒト以外の動物のエピソード的(episodic-like)記憶-WWW記憶と心的時間旅行-動物心理学研究vol. 60, pp. 105-117, 2010.
高橋良哉。老化促進モデルマウスSAMを用いた抗老化研究薬学雑誌vol. 130, pp. 11-18, 2010.
竹田俊男。老化促進モデルマウス(SAM)-老化病態とその制御を中心に日本衛生学雑誌vol. 51, pp. 569-578, 1996.
鳥羽研二、秋下雅弘、水野有三、江頭正人、金承範、阿古潤哉、寺本信嗣、長瀬隆英、長野宏一朗、須藤紀子、吉栖正雄、難波吉雄、松瀬健、大内尉義。薬剤起因性疾患日本老年医学会雑誌vol. 36, pp. 181-185, 1999.