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146

Acknowledgments

At first, I owe my deepest gratitude to Prof. Mikiko C.

Siomi for her guidance and encouragement. Dr. Kaoru Sato and

Dr. Kensaku Murano

give

me

insightful comments

and

suggestions. I thank Dr. Lumi Negishi for performing mass

spectrometry analyses. I also thank Akiko Takahashi, Ken

Ohsumi, Mina Horikoshi and Masaru Ariura for technical

assistance, Dr. Tetsutaro Sumiyoshi, Dr. Yuka W. Iwasaki, Dr.

Shigeki Hirakata and Dr. Hikari Yoshitane for advices on

bioinformatic analyses, Hiromi Yamada for proofreading of the

text and members of the Siomi laboratories. Particularly Prof.

Haruhiko Siomi, Dr. Yuka W. Iwasaki and Dr. Soichiro Yamanaka

gave me constructive comments and warm encouragement. We

also thank Prof. Lei Zhang and Prof. Susumu Hirose for sharing

antibodies and Prof. Katsuhiko Shirahige for advices on ChIP.

147

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