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大学・研究所にある論文を検索できる 「CICR（Ca2+誘発性Ca2+遊離）とリアノジン受容体(筋生理の集い)」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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CICR（Ca2+誘発性Ca2+遊離）とリアノジン受容体(筋生理の集い)

小川, 靖男 東京慈恵会医科大学

2020.11.15

概要

A hypothesis that ryanodine binds CICR channels under the open state, keeping them open is widely accepted. In this review, this hypothesis is confirmed by experiments of CICR with skinned skeletal muscle fibers and [3H]ryanodine binding to SR vesicles and purified ryanodine receptor isoforms(RyR1 and RyR3). Although there is no difference in ryanodine binding activity between the two purified isoforms, RyR1 in situ, however, remains depressed with a decreased affinity to ryanodine, where CHAPS sensitive intra- and inter-molecular interactions may be involved. These interactions could play an important roles in the etiology of malignant hyperthermia as well as in Ca2+ release on depolarization.

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参考文献

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