1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
Assinck, P.; Duncan, G.J.; Hilton, B.J.; Plemel, J.R.; Tetzlaff, W. Cell Transplantation Therapy for Spinal Cord Injury. Nat. Neurosci.
2017, 20, 637–647. [CrossRef]
Xu, X.; Shen, D.; Gao, Y.; Zhou, Q.; Ni, Y.; Meng, H.; Shi, H.; Le, W.; Chen, S.; Chen, S. A Perspective on Therapies for Amyotrophic
Lateral Sclerosis: Can Disease Progression Be Curbed? Transl. Neurodegener. 2021, 10, 29. [CrossRef]
Goutman, S.A.; Savelieff, M.G.; Sakowski, S.A.; Feldman, E.L. Stem Cell Treatments for Amyotrophic Lateral Sclerosis: A Critical
Overview of Early Phase Trials. Expert Opin. Investig. Drugs 2019, 28, 525–543. [CrossRef]
Gordon, T.; Tyreman, N.; Raji, M.A. The Basis for Diminished Functional Recovery after Delayed Peripheral Nerve Repair.
J. Neurosci. 2011, 31, 5325–5334. [CrossRef] [PubMed]
Sarhane, K.A.; Slavin, B.R.; Hricz, N.; Malapati, H.; Guo, Y.N.; Grzelak, M.; Chang, I.A.; Shappell, H.; von Guionneau, N.;
Wong, A.L.; et al. Defining the Relative Impact of Muscle versus Schwann Cell Denervation on Functional Recovery after Delayed
Nerve Repair. Exp. Neurol. 2021, 339, 113650. [CrossRef] [PubMed]
Vansteensel, M.J.; Pels, E.G.M.; Bleichner, M.G.; Branco, M.P.; Denison, T.; Freudenburg, Z.V.; Gosselaar, P.; Leinders, S.;
Ottens, T.H.; Van Den Boom, M.A.; et al. Fully Implanted Brain-Computer Interface in a Locked-In Patient with ALS. N. Engl.
J. Med. 2016, 375, 2060–2066. [CrossRef]
Slutzky, M.W. Brain-Machine Interfaces: Powerful Tools for Clinical Treatment and Neuroscientific Investigations. Neuroscientist
2019, 25, 139–154. [CrossRef] [PubMed]
Willett, F.R.; Avansino, D.T.; Hochberg, L.R.; Henderson, J.M.; Shenoy, K.V. High-Performance Brain-to-Text Communication via
Handwriting. Nature 2021, 593, 249–254. [CrossRef] [PubMed]
Lewis, M.; Rushanan, S. The Role of Physical Therapy and Occupational Therapy in the Treatment of Amyotrophic Lateral
Sclerosis. NeuroRehabilitation 2007, 22, 451–461. [CrossRef]
Gonzalez-Bermejo, J.; Morélot-Panzini, C.; Tanguy, M.L.; Meininger, V.; Pradat, P.F.; Lenglet, T.; Bruneteau, G.;
Forestier, N.L.; Couratier, P.; Guy, N.; et al. Early Diaphragm Pacing in Patients with Amyotrophic Lateral Sclerosis
(RespiStimALS): A Randomised Controlled Triple-Blind Trial. Lancet Neurol. 2016, 15, 1217–1227. [CrossRef]
Erb, D.E.; Mora, R.J.; Bunge, R.P. Reinnervation of Adult Rat Gastrocnemius Muscle by Embryonic Motoneurons Transplanted
into the Axotomized Tibial Nerve. Exp. Neurol. 1993, 124, 372–376. [CrossRef] [PubMed]
Grumbles, R.M.; Wood, P.; Rudinsky, M.; Gomez, A.M.; Thomas, C.K. Muscle Reinnervation with Delayed or Immediate
Transplant of Embryonic Ventral Spinal Cord Cells into Adult Rat Peripheral Nerve. Cell Transplant. 2002, 11, 241–250. [CrossRef]
[PubMed]
Bryson, J.B.; Machado, C.B.; Crossley, M.; Stevenson, D.; Bros-Facer, V.; Burrone, J.; Greensmith, L.; Lieberam, I. Optical Control of
Muscle Function by Transplantation of Stem Cell-Derived Motor Neurons in Mice. Science 2014, 344, 94–97. [CrossRef]
Kurimoto, S.; Kato, S.; Nakano, T.; Yamamoto, M.; Takanobu, N.; Hirata, H. Transplantation of Embryonic Motor Neurons into
Peripheral Nerve Combined with Functional Electrical Stimulation Restores Functional Muscle Activity in the Rat Sciatic Nerve
Transection Model. J. Tissue Eng. Regen. Med. 2016, 10, E477–E484. [CrossRef] [PubMed]
Int. J. Mol. Sci. 2022, 23, 8773
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
13 of 14
Asano, K.; Nakano, T.; Tokutake, K.; Ishii, H.; Nishizuka, T.; Iwatsuki, K.; Onishi, T.; Kurimoto, S.; Yamamoto, M.; Tatebe, M.; et al.
Muscle Spindle Reinnervation Using Transplanted Embryonic Dorsal Root Ganglion Cells after Peripheral Nerve Transection in
Rats. Cell Prolif. 2019, 52, e12660. [CrossRef] [PubMed]
Asano, K.; Nakano, T.; Tokutake, K.; Ishii, H.; Nishizuka, T.; Iwatsuki, K.; Onishi, T.; Kurimoto, S.; Yamamoto, M.; Tatebe, M.; et al.
Innervation of Meissner’s Corpuscles And Merkel—Cells By Transplantation of Embryonic Dorsal Root Ganglion Cells after
Peripheral Nerve Section in Rats. J. Tissue Eng. Regen. Med. 2021, 15, 586–595. [CrossRef]
Yohn, D.C.; Miles, G.B.; Rafuse, V.F.; Brownstone, R.M. Transplanted mouse embryonic stem-cell-derived motoneurons form
functional motor units and reduce muscle atrophy. J. Neurosci. 2008, 28, 12409–12418. [CrossRef]
Toma, J.S.; Shettar, B.C.; Chipman, P.H.; Pinto, D.M.; Borowska, J.P.; Ichida, J.K.; Fawcett, J.P.; Zhang, Y.; Eggan, K.; Rafuse, V.F.
Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.
J. Neurosci. 2015, 35, 1291–1306. [CrossRef]
Pepper, J.P.; Wang, T.V.; Hennes, V.; Sun, S.Y.; Ichida, J.K. Human Induced Pluripotent Stem Cell-Derived Motor Neuron
Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury. JAMA Facial Plast. Surg. 2017, 19, 197–205.
[CrossRef]
Charitos, I.A.; Ballini, A.; Cantore, S.; Boccellino, M.; Di Domenico, M.; Borsani, E.; Nocini, R.; Di Cosola, M.; Santacroce, L.;
Bottalico, L. Stem Cells: A Historical Review about Biological, Religious, and Ethical Issues. Stem Cells Int. 2021, 2021, 9978837.
[CrossRef]
Guimaraes, M.Z.P.; De Vecchi, R.; Vitoria, G.; Sochacki, J.K.; Paulsen, B.S.; Lima, I.; Rodrigues da Silva, F.; da Costa, R.F.M.;
Castro, N.G.; Breton, L.; et al. Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by
TRPV1 Agonists. Front. Mol. Neurosci. 2018, 11, 277. [CrossRef] [PubMed]
Yang, L.; Güell, M.; Niu, D.; George, H.; Lesha, E.; Grishin, D.; Aach, J.; Shrock, E.; Xu, W.; Poci, J.; et al. Genome-Wide Inactivation
of Porcine Endogenous Retroviruses (PERVs). Science 2015, 350, 1101–1104. [CrossRef] [PubMed]
Duggan, E.M.; Griesemer, A. Progress towards Xenogenic Tolerance. Curr. Opin. Organ Transplant. 2020, 25, 457–463. [CrossRef]
[PubMed]
Sauvageot, C.M.; Stiles, C.D. Molecular Mechanisms Controlling Cortical Gliogenesis. Curr. Opin. Neurobiol. 2002, 12, 244–249.
[CrossRef]
Qian, X.; Shen, Q.; Goderie, S.K.; He, W.; Capela, A.; Davis, A.A.; Temple, S. Timing of CNS Cell Generation: A Programmed
Sequence of Neuron and Glial Cell Production from Isolated Murine Cortical Stem Cells. Neuron 2000, 28, 69–80. [CrossRef]
Cooper, D.K.; Ezzelarab, M.B.; Hara, H.; Iwase, H.; Lee, W.; Wijkstrom, M.; Bottino, R. The Pathobiology of Pig-to-Primate
Xenotransplantation: A Historical Review. Xenotransplantation 2016, 23, 83–105. [CrossRef]
Patience, C.; Takeuchi, Y.; Weiss, R.A. Infection of Human Cells by an Endogenous Retrovirus of Pigs. Nat. Med. 1997, 3, 282–286.
[CrossRef]
Matsumoto, S.; Abalovich, A.; Wechsler, C.; Wynyard, S.; Elliott, R.B. Clinical Benefit of Islet Xenotransplantation for the Treatment
of Type 1 Diabetes. EBiomedicine 2016, 12, 255–262. [CrossRef]
Deacon, T.; Schumacher, J.; Dinsmore, J.; Thomas, C.; Palmer, P.; Kott, S.; Edge, A.; Penney, D.; Kassissieh, S.; Dempsey, P.; et al.
Histological Evidence of Fetal Pig Neural Cell Survival after Transplantation into a Patient with Parkinson’s Disease. Nat. Med.
1997, 3, 350–353. [CrossRef]
Aron Badin, R.; Vadori, M.; Vanhove, B.; Nerriere-Daguin, V.; Naveilhan, P.; Neveu, I.; Jan, C.; Lévèque, X.; Venturi, E.;
Mermillod, P.; et al. Cell Therapy for Parkinson’s Disease: A Translational Approach to Assess the Role of Local and Systemic
Immunosuppression. Am. J. Transplant. 2016, 16, 2016–2029. [CrossRef]
Björklund, A.; Stenevi, U.; Schmidt, R.H.; Dunnett, S.B.; Gage, F.H. Intracerebral Grafting of Neuronal Cell Suspensions. I.
Introduction and General Methods of Preparation. Acta Physiol. Scand. Suppl. 1983, 522, 1–7.
Barker, R.A.; Fricker, R.A.; Abrous, D.N.; Fawcett, J.; Dunnett, S.B. A Comparative Study of Preparation Techniques for Improving
the Viability of Nigral Grafts Using Vital Stains, In Vitro Cultures, and In Vivo Grafts. Cell Transplant. 1995, 4, 173–200. [CrossRef]
Barker, R.A.; Ratcliffe, E.; Richards, A.; Dunnett, S.B. Fetal Porcine Dopaminergic Cell Survival In Vitro and Its Relationship to
Embryonic Age. Cell Transplant. 1999, 8, 593–599. [CrossRef]
Grumbles, R.M.; Almeida, V.W.; Casella, G.T.; Wood, P.M.; Hemstapat, K.; Thomas, C.K. Motoneuron Replacement for Reinnervation of Skeletal Muscle in Adult Rats. J. Neuropathol. Exp. Neurol. 2012, 71, 921–930. [CrossRef] [PubMed]
Kato, S.; Kurimoto, S.; Nakano, T.; Yoneda, H.; Ishii, H.; Mita-Sugiura, S.; Hirata, H. Successful Transplantation of Motoneurons
into the Peripheral Nerve Depends on the Number of Transplanted Cells. Nagoya J. Med. Sci. 2015, 77, 253–263.
Sawada, H.; Kurimoto, S.; Tokutake, K.; Saeki, S.; Hirata, H. Optimal conditions for graft survival and reinnervation of denervated
muscles after embryonic motoneuron transplantation into peripheral nerves undergoing Wallerian degeneration. J. Tissue Eng.
Regen. Med. 2021, 15, 763–775. [CrossRef]
Deshpande, D.M.; Kim, Y.S.; Martinez, T.; Carmen, J.; Dike, S.; Shats, I.; Rubin, L.L.; Drummond, J.; Krishnan, C.; Hoke, A.; et al.
Recovery from Paralysis in Adult Rats Using Embryonic Stem Cells. Ann. Neurol. 2006, 60, 32–44. [CrossRef] [PubMed]
Grumbles, R.M.; Casella, G.T.; Rudinsky, M.J.; Godfrey, S.; Wood, P.M.; Thomas, C.K. The Immunophilin Ligand FK506, but
Not the P38 Kinase Inhibitor SB203580, Improves Function of Adult Rat Muscle Reinnervated from Transplants of Embryonic
Neurons. Neuroscience 2005, 130, 619–630. [CrossRef]
Int. J. Mol. Sci. 2022, 23, 8773
39.
40.
41.
14 of 14
Grumbles, R.M.; Sesodia, S.; Wood, P.M.; Thomas, C.K. Neurotrophic Factors Improve Motoneuron Survival and Function of
Muscle Reinnervated by Embryonic Neurons. J. Neuropathol. Exp. Neurol. 2009, 68, 736–746. [CrossRef] [PubMed]
Yu, P.; Matloub, H.S.; Sanger, J.R.; Narini, P. Gait Analysis in Rats with Peripheral Nerve Injury. Muscle Nerve 2001, 24, 231–239.
[CrossRef]
Rueden, C.T.; Schindelin, J.; Hiner, M.C.; DeZonia, B.E.; Walter, A.E.; Arena, E.T.; Eliceiri, K.W. ImageJ2: ImageJ for the next
generation of scientific image data. BMC Bioinform. 2017, 18, 529. [CrossRef] [PubMed]
...
論文の公開元へ
