Barreiro, E., de la Puente, B., Busquets, S., Lopez-Soriano, F. J., Gea, J., and Argiles,
J. M. (2005). Both oxidative and nitrosative stress are associated with muscle
wasting in tumour-bearing rats. FEBS Lett. 579, 1646–1652. doi: 10.1016/j.
febslet.2005.02.017
DATA AVAILABILITY STATEMENT
The datasets used and/or analyzed during the current study are
available from the corresponding author on reasonable request.
ETHICS STATEMENT
The experimental protocol was approved by the committee of
animal research at Mie University.
AUTHOR CONTRIBUTIONS
TN and MT designed the research and wrote the manuscript. TI
and TA participated in the experimental design and techniques.
AS did final editing. All authors read and approved the
final manuscript.
FUNDING
This study was supported by Grant-in-Aid for Scientific Research
grants from the Japan Society for the Promotion of Science. This
study was also supported by Department of Orthopaedic Surgery,
Graduate School of Medicine Mie University (No. 26462238) and
the committee of animal research at Mie University. The funder
had no involvement in the design of the study and collection,
analysis, and interpretation of data and in writing the manuscript.
Akhmedov, D., and Berdeaux, R. (2013). The effects of obesity on skeletal muscle
regeneration. Front. Physiol. 4:371. doi: 10.3389/fphys.2013.00371
Frontiers in Physiology | www.frontiersin.org
January 2020 | Volume 10 | Article 1596
Nakanishi et al.
Skeletal Muscles in Ob/ob Mice
Brownlee, M. (2001). Biochemistry and molecular cell biology of
diabetic complications. Nature 414, 813–820. doi: 10.1038/41
4813a
Choi, M. H., Ow, J. R., Yang, N. D., and Taneja, R. (2016). Oxidative
stress-mediated skeletal muscle degeneration: molecules, mechanisms, and
therapies. Oxid. Med. Cell Longev. 2016:6842568. doi: 10.1155/2016/684
2568
Conti, V., Corbi, G., Simeon, V., Russomanno, G., Manzo, V., Ferrara, N.,
et al. (2015). Aging-related changes in oxidative stress response of human
endothelial cells. Aging Clin. Exp. Res. 27, 547–553. doi: 10.1007/s40520-0150357-9
Crawford, R. S., Albadawi, H., Robaldo, A., Peck, M. A., Abularrage, C. J., Yoo, H. J.,
et al. (2013). Divergent systemic and local inflammatory response to hind limb
demand ischemia in wild-type and ApoE-/- mice. J. Surg. Res. 183, 952–962.
doi: 10.1016/j.jss.2013.02.042
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi,
F., et al. (2010). Sarcopenia: European consensus on definition and diagnosis:
report of the european working group on sarcopenia in older people. Age Ageing
39, 412–423. doi: 10.1093/ageing/afq034
Di Lascio, N., Kusmic, C., Stea, F., Lenzarini, F., Barsanti, C., Leloup, A., et al.
(2018). Longitudinal micro-ultrasound assessment of the ob/ob mouse model:
evaluation of cardiovascular, renal and hepatic parameters. Int. J. Obes. 42,
518–524. doi: 10.1038/ijo.2017.219
Enoki, H., Kuzuya, M., Masuda, Y., Hirakawa, Y., Iwata, M., Hasegawa, J.,
et al. (2007). Anthropometric measurements of mid-upper arm as a mortality
predictor for community-dwelling Japanese elderly: the Nagoya Longitudinal
Study of Frail Elderly (NLS-FE). Clin. Nutr. 26, 597–604. doi: 10.1016/j.clnu.
2007.06.008
Fujiwara, N., Som, A. T., Pham, L. D., Lee, B. J., Mandeville, E. T., Lo, E. H., et al.
(2016). A free radical scavenger edaravone suppresses systemic inflammatory
responses in a rat transient focal ischemia model. Neurosci. Lett. 633, 7–13.
doi: 10.1016/j.neulet.2016.08.048
Fukawa, T., Yan-Jiang, B. C., Min-Wen, J. C., Jun-Hao, E. T., Huang, D.,
Qian, C. N., et al. (2016). Excessive fatty acid oxidation induces muscle
atrophy in cancer cachexia. Nat. Med. 22, 666–671. doi: 10.1038/nm.
4093
Gadjeva, V., Dimov, A., and Georgieva, N. (2008). Influence of therapy on the
antioxidant status in patients with melanoma. J. Clin. Pharm. Ther. 33, 179–185.
doi: 10.1111/j.1365-2710.2008.00909.x
Gamez-Mendez, A. M., Vargas-Robles, H., Rios, A., and Escalante, B.
(2015). Oxidative stress-dependent coronary endothelial dysfunction
in obese mice. PLoS One 10:e0138609. doi: 10.1371/journal.pone.013
8609
Hassan, M. Q., Akhtar, M. S., Akhtar, M., Ali, J., Haque, S. E., and Najmi, A. K.
(2015). Edaravone protects rats against oxidative stress and apoptosis in
experimentally induced myocardial infarction: biochemical and ultrastructural
evidence. Redox Rep. 20, 275–281. doi: 10.1179/1351000215y.000000
0011
Hayashi, C., Ito, M., Ito, R., Murakumo, A., Yamamoto, N., Hiramatsu, N.,
et al. (2014). Effects of edaravone, a radical scavenger, on hepatocyte
transplantation. J. Hepatobiliary Pancreat. Sci. 21, 919–924. doi: 10.1002/
jhbp.164
Hori, K., Tsujii, M., Iino, T., Satonaka, H., Uemura, T., Akeda, K., et al. (2013).
Protective effect of edaravone for tourniquet-induced ischemia-reperfusion
injury on skeletal muscle in murine hindlimb. BMC Musculoskelet. Disord.
14:113. doi: 10.1186/1471-2474-14-113
Isomaa, B., Almgren, P., Tuomi, T., Forsen, B., Lahti, K., Nissen, M., et al.
(2001). Cardiovascular morbidity and mortality associated with the metabolic
syndrome. Diabetes Care 24, 683–689.
Kalinkovich, A., and Livshits, G. (2017). Sarcopenic obesity or obese sarcopenia:
a cross talk between age-associated adipose tissue and skeletal muscle
inflammation as a main mechanism of the pathogenesis. Ageing Res. Rev. 35,
200–221. doi: 10.1016/j.arr.2016.09.008
Kikuchi, K., Tancharoen, S., Takeshige, N., Yoshitomi, M., Morioka, M., Murai,
Y., et al. (2013). The efficacy of edaravone (radicut), a free radical scavenger,
for cardiovascular disease. Int. J. Mol. Sci. 14, 13909–13930. doi: 10.3390/
ijms140713909
Frontiers in Physiology | www.frontiersin.org
Kohara, K. (2014). Sarcopenic obesity in aging population: current status and
future directions for research. Endocrine 45, 15–25. doi: 10.1007/s12020-0139992-0
Kohara, K., Ochi, M., Tabara, Y., Nagai, T., Igase, M., and Miki, T. (2011).
Leptin in sarcopenic visceral obesity: possible link between adipocytes
and myocytes. PLoS One 6:e24633. doi: 10.1371/journal.pone.002
4633
Li, F., Li, Y., Tang, Y., Lin, B., Kong, X., Oladele, O. A., et al. (2014).
Protective effect of myokine IL-15 against H2O2-mediated oxidative stress in
skeletal muscle cells. Mol. Biol. Rep. 41, 7715–7722. doi: 10.1007/s11033-0143665-9
Maffiuletti, N. A., Jubeau, M., Munzinger, U., Bizzini, M., Agosti, F., De Col, A.,
et al. (2007). Differences in quadriceps muscle strength and fatigue between lean
and obese subjects. Eur. J. Appl. Physiol. 101, 51–59. doi: 10.1007/s00421-0070471-2
Manna, P., and Jain, S. K. (2015). Obesity, oxidative stress, adipose tissue
dysfunction, and the associated health risks: causes and therapeutic
strategies. Metab. Syndr. Relat. Disord. 13, 423–444. doi: 10.1089/met.2015.
0095
Marseglia, L., Manti, S., D’Angelo, G., Nicotera, A., Parisi, E., Di Rosa, G., et al.
(2014). Oxidative stress in obesity: a critical component in human diseases. Int.
J. Mol. Sci. 16, 378–400. doi: 10.3390/ijms16010378
McCormack, M. C., Kwon, E., Eberlin, K. R., Randolph, M., Friend, D. S., Thomas,
A. C., et al. (2008). Development of reproducible histologic injury severity
scores: skeletal muscle reperfusion injury. Surgery 143, 126–133. doi: 10.1016/j.
surg.2007.06.005
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E. M., Goodpaster, B. H.,
Kritchevsky, S. B., et al. (2006). Strength, but not muscle mass, is associated with
mortality in the health, aging and body composition study cohort. J. Gerontol.
A Biol. Sci. Med. Sci. 61, 72–77.
Nguyen, M. H., Cheng, M., and Koh, T. J. (2011). Impaired muscle regeneration
in ob/ob and db/db mice. Sci. World J. 11, 1525–1535. doi: 10.1100/tsw.
2011.137
Ni, H. Y., Song, Y. X., Wu, H. Y., Chang, L., Luo, C. X., and Zhu, D. Y. (2018). 2Methyl-5H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine, an edaravone analog,
exerts neuroprotective effects against acute ischemic injury via inhibiting
oxidative stress. J. Biomed. Res. 32, 270–280. doi: 10.7555/jbr.32.201
80014
Plummer, M. R., and Hasty, A. H. (2008). Atherosclerotic lesion formation and
triglyceride storage in obese apolipoprotein AI-deficient mice. J. Nutr. Biochem.
19, 664–673. doi: 10.1016/j.jnutbio.2007.08.009
Powers, S. K., Kavazis, A. N., and McClung, J. M. (2007). Oxidative stress and disuse
muscle atrophy. J. Appl. Physiol. 102, 2389–2397. doi: 10.1152/japplphysiol.
01202.2006
Powers, S. K., Morton, A. B., Ahn, B., and Smuder, A. J. (2016). Redox control
of skeletal muscle atrophy. Free Radic. Biol. Med. 98, 208–217. doi: 10.1016/j.
freeradbiomed.2016.02.021
Quigley, J. E., Elmarakby, A. A., Knight, S. F., Manhiani, M. M., Stepp, D. W.,
Olearzcyk, J. J., et al. (2009). Obesity induced renal oxidative stress contributes
to renal injury in salt-sensitive hypertension. Clin. Exp. Pharmacol. Physiol. 36,
724–728. doi: 10.1111/j.1440-1681.2009.05139.x
Ren, Y., Li, Y., Yan, J., Ma, M., Zhou, D., Xue, Z., et al. (2017). Adiponectin
modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts
against apoptosis. Sci. Rep. 7:3209. doi: 10.1038/s41598-017-03319-2
Sainz, N., Rodriguez, A., Catalan, V., Becerril, S., Ramirez, B., Gomez-Ambrosi,
J., et al. (2010). Leptin administration downregulates the increased expression
levels of genes related to oxidative stress and inflammation in the skeletal
muscle of ob/ob mice. Mediators Inflamm. 2010:784343. doi: 10.1155/2010/
784343
Scherz-Shouval, R., and Elazar, Z. (2007). ROS, mitochondria and the regulation
of autophagy. Trends Cell Biol. 17, 422–427. doi: 10.1016/j.tcb.2007.
07.009
Tidball, J. G. (2011). Mechanisms of muscle injury, repair, and regeneration.
Compr. Physiol. 1, 2029–2062. doi: 10.1002/cphy.c100092
Toufektsian, M. C., Boucher, F. R., Tanguy, S., Morel, S., and de Leiris, J. G. (2001).
Cardiac toxicity of singlet oxygen: implication in reperfusion injury. Antioxid.
Redox Signal. 3, 63–69. doi: 10.1089/152308601750100506
January 2020 | Volume 10 | Article 1596
Nakanishi et al.
Skeletal Muscles in Ob/ob Mice
Vincent, H. K., Innes, K. E., and Vincent, K. R. (2007). Oxidative stress
and potential interventions to reduce oxidative stress in overweight and
obesity. Diabetes Obes. Metab. 9, 813–839. doi: 10.1111/j.1463-1326.2007.
00692.x
Wang, H. M., Zhang, T., Huang, J. K., Xiang, J. Y., Chen, J. J., Fu, J. L., et al. (2017).
Edaravone attenuates the proinflammatory response in amyloid-beta-treated
microglia by inhibiting NLRP3 inflammasome-mediated IL-1beta secretion.
Cell Physiol. Biochem. 43, 1113–1125. doi: 10.1159/000481753
Yang, S., Chou, W. P., and Pei, L. (2013). Effects of propofol on renal
ischemia/reperfusion injury in rats. Exp. Ther. Med. 6, 1177–1183. doi: 10.3892/
etm.2013.1305
Yoshida, H., Yanai, H., Namiki, Y., Fukatsu-Sasaki, K., Furutani, N., and Tada, N.
(2006). Neuroprotective effects of edaravone: a novel free radical scavenger in
cerebrovascular injury. CNS Drug Rev. 12, 9–20. doi: 10.1111/j.1527-3458.2006.
00009.x
Frontiers in Physiology | www.frontiersin.org
Zhang, N., Komine-Kobayashi, M., Tanaka, R., Liu, M., Mizuno, Y., and Urabe,
T. (2005). Edaravone reduces early accumulation of oxidative products and
sequential inflammatory responses after transient focal ischemia in mice brain.
Stroke 36, 2220–2225. doi: 10.1161/01.str.0000182241.07096.06
Conflict of Interest: The authors declare that the research was conducted in the
absence of any commercial or financial relationships that could be construed as a
potential conflict of interest.
Copyright © 2020 Nakanishi, Tsujii, Asano, Iino and Sudo. This is an open-access
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