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Tumour-immune microenvironment in duodenal-type follicular lymphoma

井上 宏昭 近畿大学

2022.03.02

概要

Despite duodenal-type follicular lymphoma (DTFL) is morphologically, immunophenotypically, and genetically indistinguishable from nodal FL (nFL), this entity typically shows a significant better prognosis. Here, we analyzed the tumor immune microenvironments of diagnostic specimens from patients with DTFL (n=30), limited-stage FL (LSFL; n=19) and advanced-stage FL (ASFL; n=31). The mean number of CD8+ tumor infiltrating lymphocytes (TILs) in the neoplastic follicles was higher in DTFL (1,827/mm2 ) than in LSFL (1,150/mm2 ) and ASFL (1,188/mm2 ) (P=0.002, P=0.002, respectively). In addition, CD8+PD1- T cells with non-exhausting phenotype were more abundant in the peripheral blood (PB) of DTFL than in LSFL and ASFL, indicating that DTFL may exhibit a better and longerlasting T cell-mediated immune response. Moreover, whereas FOXP3+CTLA-4 + effector regulatory T cells (eTregs) were rarely observed in the neoplastic follicles of DTFL (mean: 12/mm2 ), they were more abundant in LSFL (78/mm2 ) and ASFL (109/mm2 ) (P=2.80×10-5 , P=4.74×10-8 , respectively), and the numbers of eTregs correlated inversely with those of CD8+ TILs (r=-0267; P=0.018). Furthermore, DTFL showed significantly fewer circulating FOXP3hiCD45RA-CD25hi eTregs (0.146%) than ASFL (0.497%) and healthy controls (0.639%) (P=0.0003, P=6.79×10-7 , respectively). These results suggest that the augmented anti-tumor immune reactions may contribute to better prognosis on DTFL.

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