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大学・研究所にある論文を検索できる 「Construction of a single-cell atlas of non-hematopoietic cells in human lymph nodes and lymphoma for dissecting stromal remodeling」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Construction of a single-cell atlas of non-hematopoietic cells in human lymph nodes and lymphoma for dissecting stromal remodeling

安部, 佳亮 筑波大学 DOI:10.15068/0002006208

2023.01.17

概要

Lymphomas are the most common haematologic malignancies that often develop from lymph nodes (LNs). It is seventh and eighth common cancer in western countries and in Japan, respectively, and the incidence is higher in the elderly and increasing worldwide according to the population aging. Although some clinical factors have been suggested to increase the risk of lymphoma development, little is known regarding the causes of most lymphoma subtypes. Based on the recent classification1, lymphoma is a highly heterogenous disease encompassing more than 80 subtypes with different pathological, genetical, and clinical features. Conventionally, they are categorized into Hodgkin and non-Hodgkin lymphoma and the latter is further roughly divided into B-cell and T/NK- cell lymphomas. Hodgkin lymphoma comprises approximately 5–15% of all lymphomas, whereas non-Hodgkin lymphoma comprises >80%. In non-Hodgkin lymphoma, B-cell lymphomas account for >80%. The representatives of B-cell lymphomas include diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL): the two subtypes account for more than half of non-Hodgkin lymphomas.

From a clinical point of view, common symptoms of lymphomas include painless lymphadenopathy, persistent fatigue, fever, night sweat, and unexplained wight loss, although a part of patients experience disease site-specific symptoms such as neurological signs, shortness of breath, and abdominal distention. Lymphoma diagnosis is usually made pathologically on biopsy specimens of the swollen lymph nodes.

Imaging tests including computerized tomography scan, blood tests, and cytogenetic examinations of the samples are also performed to support the diagnosis and/or to determine the clinical stage of lymphoma. Treatment depends on the subtype and stage of lymphoma and patient factors including age, comorbidities, and general status.

Multidrug chemotherapy is selected in most of the lymphoma cases aiming at disease remission. Prognosis also varies by cases, lymphoma subtypes, and clinical stages.

Recently, molecular targeted drugs such as anti-CD20 antibody are frequently used in many cases, which have greatly improved the clinical outcomes of lymphoma. Despite considerable advances in chemotherapies during the last decades, most lymphoma subtypes remain incurable; a significant part of patients finally experience relapse and disease-associated death. Therefore, new therapeutic approaches, including those targeting not only cancer cells but also the tumour microenvironment (TME), are needed2,3. In lymphomas, as in solid cancers4,5, the activities of non-haematopoietic cells (NHCs), such as mesenchymal stromal cells (SCs) and endothelial cells, are thought to facilitate lymphomagenesis, and thus offer potential as therapeutic targets2,3.

Indeed, some lymphoma subtypes reportedly exhibit unique interactions with NHCs6-9, although lymphoma NHC research is far behind that of solid cancers10.

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