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6. Conclusion
In endogenous glucocorticoid excess, bone and vascular diseases
frequently coexisted, and deteriorated bone quality, not bone loss, was
related to arterial stiffness. This study may contribute to the appropriate
management of such patients and provide new insights into our un
derstanding of the bone-vascular axis.
Data availability
Data supporting the findings presented in this study are available
from the corresponding authors upon reasonable request.
Funding
This work was supported in part by the grants from “JSPS KAKENHI”
(JP20K16525 and 21J40043 to M. Y-U., 22H04993 to Y.O., and
22K08627 to H.U.), “The JSBMR Rising Stars Grant” (to M. Y-U.),
“JAPAN Osteoporosis Foundation” (to M. Y-U.), “Takeda Science
Foundation” (to H.U.), “Kaibara Morikazu Medical Science Promotion
Foundation” (to H.U. and M. Y-U.), “Japan Foundation for Applied
Enzymology” (to H.U. and M. Y-U.), “The Uehara Memorial Foundation”
(to H.U.), and “Secom Science and Technology Foundation” (to Y.O.).
CRediT authorship contribution statement
Conceptualization; CY, MY-U, YO, Data curation; CY, RS, YM, SK, NI,
Formal analysis; CY, MY-U, MF, MO, TF, Funding acquisition; MY-U,
HU, YO, Methodology; HU, MY-U, YO, Project administration; HU,
YM, MY-U, YO; Resources; YM, RS, MY-U, Supervision; HU, NI, RS, ET,
YO, Writing-original draft; CY, MY-U, Writing- review & editing; CY,
MY-U, HU, SY, YO.
Declaration of competing interest
The authors declare that they have no known competing financial
interests or personal relationships that could have appeared to influence
the work reported in this paper.
Acknowledgments
We thank Ms. Chitose Matsuzaki (Department of Medicine and Bio
regulatory Science, Graduate School of Medical Sciences, Kyushu Uni
versity), and Ms. Tomoko Kimura and Ms. Noriko Mizoguchi (Division of
Radiology, Department of Medical Technology, Kyushu University
Hospital) for their technical assistance, and the medical staff of
Department of Endocrinology, Metabolism, and Diabetes, Kyushu Uni
versity Hospital for their support. We also thank Editage (www.editage.
com) for English language editing. M.Y-U. is grateful for the JSPS
Research Fellowship RPD.
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