Bronckaers, A., Gago, F., Balzarini, J., and Liekens, S. (2009). The dual role of thymidine phosphorylase in cancer development and chemotherapy. Med Res Rev 29, 903-953.
Brunetti, G., Rizzi, R., Oranger, A., Gigante, I., Mori, G., Taurino, G., Mongelli, T., Colaianni, G., Di Benedetto, A., Tamma, R., et al. (2014). LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease. Oncotarget 5, 12950-12967.
Chen, D., Zhang, X., Guo, Y., Shi, S., Mao, X., Pan, X., and Cheng, T. (2012). MMP-9 inhibition suppresses wear debris-induced inflammatory osteolysis through downregulation of RANK/RANKL in a murine osteolysis model. Int J Mol Med 30, 1417-1423.
Chen, S., Zhou, Y., Chen, Y., and Gu, J. (2018). fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 34, i884-i890.
Cobelli, N., Scharf, B., Crisi, G.M., Hardin, J., and Santambrogio, L. (2011). Mediators of the inflammatory response to joint replacement devices. Nat Rev Rheumatol 7, 600-608.
Collison, J. (2018). Rheumatoid arthritis: Tocilizumab prevents progression of bone erosions. Nat Rev Rheumatol 14, 4.
Dobin, A., Davis, C.A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., and Gingeras, T.R. (2013). STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15-21. Feldmann, M., and Maini, R.N. (2003). Lasker Clinical Medical Research Award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 9, 1245- 1250.
Garrigues, G.E., Cho, D.R., Rubash, H.E., Goldring, S.R., Herndon, J.H., and Shanbhag, A.S. (2005). Gene expression clustering using self-organizing maps: analysis of the macrophage response to particulate biomaterials. Biomaterials 26, 2933-2945.
Goto, T., Shinmura, K., Yokomizo, K., Sakuraba, K., Kitamura, Y., Shirahara, A., Saito, M., Kigawa, G., Nemoto, H., Sanada, Y., et al. (2012). Expression Levels of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase, and Thymidine Phosphorylase in Patients with Colorectal Cancer. Anticancer Res, 1757-1762.
Gu, Q., Yang, H., and Shi, Q. (2017). Macrophages and bone inflammation. J Orthop Translat 10, 86-93.
Heusschen, R., Muller, J., Binsfeld, M., Marty, C., Plougonven, E., Dubois, S., Mahli, N., Moermans, K., Carmeliet, G., Leonard, A., et al. (2016). SRC kinase inhibition with saracatinib limits the development of osteolytic bone disease in multiple myeloma. Oncotarget 7, 30712- 30729.
Hirano, M., Lagier-Tourenne, C., Valentino, M.L., Marti, R., and Nishigaki, Y. (2005). Thymidine phosphorylase mutations cause instability of mitochondrial DNA. Gene 354, 152-156.
Huang, J.B., Ding, Y., Huang, D.S., Liang, A.J., Zeng, W.K., Zeng, Z.P., Qin, C.Q., and Barden, B. (2013). Inhibition of the PI3K/AKT pathway reduces tumor necrosis factor-alpha production in the cellular response to wear particles in vitro. Artif Organs 37, 298-307.
Ingham, E., and Fisher, J. (2005). The role of macrophages in osteolysis of total joint replacement. Biomaterials 26, 1271-1286.
Kandahari, A.M., Yang, X., Laroche, K.A., Dighe, A.S., Pan, D., and Cui, Q. (2016). A review of UHMWPE wear-induced osteolysis: the role for early detection of the immune response. Bone Res 4, 16014.
Kawahara, A., Hattori, S., Akiba, J., Nakashima, K., Taira, T., Watari, K., Hosoi, F., Uba, M., Basaki, Y., Koufuji, K., et al. (2010). Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer. Oncol Rep 24, 405-415.
Kim, H.J., Warren, J.T., Kim, S.Y., Chappel, J.C., DeSelm, C.J., Ross, F.P., Zou, W., and Teitelbaum, S.L. (2010). Fyn promotes proliferation, differentiation, survival and function of osteoclast lineage cells. J Cell Biochem 111, 1107-1113.
Kitaura, H., Kimura, K., Ishida, M., Kohara, H., Yoshimatsu, M., and Takano-Yamamoto, T. (2013). Immunological reaction in TNF-alpha-mediated osteoclast formation and bone resorption in vitro and in vivo. Clin Dev Immunol 2013, 181849.
Li, B., and Dewey, C.N. (2011). RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 12, 323.
Li, W., and Yue, H. (2018). Thymidine phosphorylase: A potential new target for treating cardiovascular disease. Trends Cardiovasc Med 28, 157-171.
Liang, X., Draghi, N.A., and Resh, M.D. (2004). Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes. J Neurosci 24, 7140-7149. Liu, H., Liu, Z., Du, J., He, J., Lin, P., Amini, B., Starbuck, M.W., Novane, N., Shah, J.J., Davis, R.E., et al. (2016). Thymidine phosphorylase exerts complex effects on bone resorption and formation in myeloma. Sci Transl Med 8, 353ra113.
Lovatt, M., Filby, A., Parravicini, V., Werlen, G., Palmer, E., and Zamoyska, R. (2006). Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response. Mol Cell Biol 26, 8655-8665.
Mbalaviele, G., Novack, D.V., Schett, G., and Teitelbaum, S.L. (2017). Inflammatory osteolysis: a conspiracy against bone. J Clin Invest 127, 2030-2039.
Miron, R.J., and Bosshardt, D.D. (2016). OsteoMacs: Key players around bone biomaterials. Biomaterials 82, 1-19.
Miyazaki, T., Sanjay, A., Neff, L., Tanaka, S., Horne, W.C., and Baron, R. (2004). Src kinase activity is essential for osteoclast function. J Biol Chem 279, 17660-17666.
Nakagawa, M., Kaneda, T., Arakawa, T., Morita, S., Sato, T., Yomada, T., Hanada, K., Kumegawa, M., and Hakeda, Y. (2000). Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. FEBS Lett 473.
Nakashima, T., and Takayanagi, H. (2011). New regulation mechanisms of osteoclast differentiation. Ann N Y Acad Sci 1240, E13-18.
Nich, C., Takakubo, Y., Pajarinen, J., Ainola, M., Salem, A., Sillat, T., Rao, A.J., Raska, M., Tamaki, Y., Takagi, M., et al. (2013). Macrophages-Key cells in the response to wear debris from joint replacements. J Biomed Mater Res A 101, 3033-3045.
Quintela-Lopez, T., Ortiz-Sanz, C., Serrano-Regal, M.P., Gaminde-Blasco, A., Valero, J., Baleriola, J., Sanchez-Gomez, M.V., Matute, C., and Alberdi, E. (2019). Abeta oligomers promote oligodendrocyte differentiation and maturation via integrin beta1 and Fyn kinase signaling. Cell Death Dis 10, 445.
Ritchlin, C.T., Haas-Smith, S.A., Li, P., Hicks, D.G., and Schwarz, E.M. (2003). Mechanisms of TNF-α– and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. Journal of Clinical Investigation 111, 821-831.
Sabokbar, A., Mahoney, D.J., Hemingway, F., and Athanasou, N.A. (2016). Non-Canonical (RANKL-Independent) Pathways of Osteoclast Differentiation and Their Role in Musculoskeletal Diseases. Clin Rev Allergy Immunol 51, 16-26.
Shimaoka, S., Matsushita, S., Nitanda, T., Matsuda, A., Nioh, T., Suenaga, T., Nishimata, Y., Akiba, S., Akiyama, S., and Nishimata, H. (2000). The Role of Thymidine Phosphorylase Expression in the Invasiveness of Gastric Carcinoma. Cancer, 2220-2227.
Terkawi, M.A., Hamasaki, M., Takahashi, D., Ota, M., Kadoya, K., Yutani, T., Uetsuki, K., Asano, T., Irie, T., Arai, R., et al. (2018). Transcriptional profile of human macrophages stimulated by ultra-high molecular weight polyethylene particulate debris of orthopedic implants uncovers a common gene expression signature of rheumatoid arthritis. Acta Biomater 65, 417-425.
Terkawi, M.A., Kadoya, K., Takahashi, D., Tian, Y., Hamasaki, M., Matsumae, G., Alhasan, H., Elmorsy, S., Uetsuki, K., Onodera, T., et al. (2019). Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants. Acta Biomater 89, 242-251.
Toyoda, Y., Tabata, S., Kishi, J., Kuramoto, T., Mitsuhashi, A., Saijo, A., Kawano, H., Goto, H., Aono, Y., Hanibuchi, M., et al. (2014). Thymidine phosphorylase regulates the expression of CXCL10 in rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheumatol 66, 560-568. Udalova, I.A., Mantovani, A., and Feldmann, M. (2016). Macrophage heterogeneity in the context of rheumatoid arthritis. Nat Rev Rheumatol 12, 472-485.
Werner, J.H., Rosenberg, J.H., Keeley, K.L., and Agrawal, D.K. (2018). Immunobiology of periprosthetic inflammation and pain following ultra-high-molecular-weight-polyethylene wear debris in the lumbar spine. Expert Rev Clin Immunol 14, 695-706.
Wooley, P.H., and Schwarz, E.M. (2004). Aseptic loosening. Gene Ther 11, 402-407.
Yu, H., Lin, L., Zhang, Z., Zhang, H., and Hu, H. (2020). Targeting NF-kappaB pathway for the therapy of diseases: mechanism and clinical study. Signal Transduct Target Ther 5, 209.
Zhou, F., Lu, Zhu, X., Mao, H., Yang, H., Geng, D., and Xu, Y. (2010). Effects of a cannabinoid receptor 2 selective antagonist on the inflammatory reaction to titanium particles in vivo and in vitro. J Int Med Res 38, 2023-2032.