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大学・研究所にある論文を検索できる 「Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。
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Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging

Yoshida, Naohiro 京都大学 DOI:10.14989/doctor.r13388

2021.01.25

概要

Objective
Early detection of gastric cancer has been the topic of major efforts in high prevalence areas. Whether advanced imaging methods, such as secondgeneration narrow band imaging (2G--NBI) can improve early detection, is unknown.

Design
This open-label, randomised, controlled tandem trial was conducted in 13 hospitals. Patients at increased risk for gastric cancer were randomly assigned to primary white light imaging (WLI) followed by secondary 2G-¬NBI (WLI group: n=2258) and primary 2G-¬NBI followed by secondary WLI (2G-¬NBI group: n=2265) performed by the same examiner. Suspected early gastric cancer (EGC) lesions in both groups were biopsied. Primary endpoint was the rate of EGC patients in the primary examination. The main secondary endpoint was the positive predictive value (PPV) for EGC in suspicious lesions detected (primary examination).

Results
EGCs were found in 44 (1.9%) and 53 (2.3%; p=0.412) patients in the WLI and 2G-¬NBI groups, respectively, during primary EGD. In a post hoc analysis, the overall rate of lesions detected at the second examination was 25% (n=36/145), with no significant differences between groups. PPV for EGC in suspicious lesions was 13.5% and 20.9% in the WLI (50/371 target lesions) and 2G-¬NBI groups (59/282 target lesions), respectively (p=0.015).

Conclusion
The overall sensitivity of primary endoscopy for the detection of EGC in high-risk patients was only 75% and should be improved. 2G-¬NBI did not increase EGC detection rate over conventional WLI. The impact of a slightly better PPV of 2G-¬NBI has to be evaluated further

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s 1 Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394–424.

2 Katai H, Ishikawa T, Akazawa K, et al. Five-Year survival analysis of surgically resected gastric cancer cases in Japan: a retrospective analysis of more than 100,000 patients from the nationwide registry of the Japanese gastric cancer association (2001-2007). Gastric Cancer 2018;21:144–54.

3 Choi KS, Jun JK, Park E-¬C, et al. Performance of different gastric cancer screening methods in Korea: a population-based study. PLoS One 2012;7:e50041.

4 Hamashima C. Benefits and harms of endoscopic screening for gastric cancer. World J Gastroenterol 2016;22:6385–92.

5 Gono K, Obi T, Yamaguchi M, et al. Appearance of enhanced tissue features in narrowband endoscopic imaging. J Biomed Opt 2004;9:568–77.

6 Muto M, Minashi K, Yano T, et al. Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial. J Clin Oncol 2010;28:1566–72.

7 Nakajima T, Oda I, Gotoda T, et al. Metachronous gastric cancers after endoscopic resection: how effective is annual endoscopic surveillance? Gastric Cancer 2006;9:93–8.

8 Kato M, Nishida T, Yamamoto K, et al. Scheduled endoscopic surveillance controls secondary cancer after curative endoscopic resection for early gastric cancer: a multicentre retrospective cohort study by Osaka university ESD Study Group. Gut 2013;62:1425–32.

9 Jang MY, Cho JW, Oh WG, et al. Clinicopathological characteristics of synchronous and metachronous gastric neoplasms after endoscopic submucosal dissection. Korean J Intern Med 2013;28:687–93.

10 Ławniczak M, Gawin A, Jaroszewicz-¬Heigelmann H, et al. Synchronous and metachronous neoplasms in gastric cancer patients: a 23-year study. World J Gastroenterol 2014;20:7480.

11 Shibuya H, Wakita T, Nakagawa T, et al. The relation between an esophageal cancer and associated cancers in adjacent organs. Cancer 1995;76:101–5.

12 Natsugoe S, Matsumoto M, Okumura H, et al. Multiple primary carcinomas with esophageal squamous cell cancer: clinicopathologic outcome. World J Surg 2005;29:46–9.

13 Masuda M, Kuwano H, Okumura M, et al. Thoracic and cardiovascular surgery in Japan during 2012. Gen Thorac Cardiovasc Surg 2014;62:734–64.

14 Cancer Registry and Statistics. Cancer information service, National cancer center, Japan, 2019. Available: https://ganjoho.jp/reg_stat/statistics/dl/index.html [Accessed 20 Oct 2019].

15 Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer 2011;14:101–12.

16 Yao K. The endoscopic diagnosis of early gastric cancer. Ann Gastroenterol Q Publ Hell Soc Gastroenterol 2013;26:11–22.

17 Dixon MF. Gastrointestinal epithelial neoplasia: Vienna revisited. Gut 2002;51:130–1.

18 Ezoe Y, Muto M, Uedo N, et al. Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer. Gastroenterology 2011;141:2017–25.

19 Zhang X, Li M, Chen S, et al. Endoscopic screening in Asian countries is associated with reduced gastric cancer mortality: a meta-analysis and systematic review. Gastroenterology 2018;155:347–54.

20 Ono H, Yao K, Fujishiro M, et al. Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer. Dig Endosc 2016;28:3–15.

21 Hasuike N, Ono H, Boku N, et al. A non-randomized confirmatory trial of an expanded indication for endoscopic submucosal dissection for intestinal-type gastric cancer (cT1a): the Japan clinical Oncology Group study (JCOG0607). Gastric Cancer 2018;21:114–23.

22 Kim Y, Kim YW, Choi IJ, et al. Cost comparison between surgical treatments and endoscopic submucosal dissection in patients with early gastric cancer in Korea. Gut Liver 2015;9:174–80.

23 Libânio D, Braga V, Ferraz S, et al. Prospective comparative study of endoscopic submucosal dissection and gastrectomy for early neoplastic lesions including patients’ perspectives. Endoscopy 2019;51:30–9.

24 Yao K, Anagnostopoulos GK, Ragunath K. Magnifying endoscopy for diagnosing and delineating early gastric cancer. Endoscopy 2009;41:462–7.

25 Nagahama T, Yao K, Maki S, et al. Usefulness of magnifying endoscopy with narrowband imaging for determining the horizontal extent of early gastric cancer when there is an unclear margin by chromoendoscopy (with video). Gastrointest Endosc 2011;74:1259–67.

26 Kato M, Uedo N, Hokimoto S, et al. Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment: 2017 Appendix on Anticoagulants Including Direct Oral Anticoagulants. Dig Endosc 2018;30:433–40.

27 Veitch AM, Vanbiervliet G, Gershlick AH, et al. Endoscopy in patients on antiplatelet or anticoagulant therapy, including direct oral anticoagulants: British Society of gastroenterology (Bsg) and European Society of gastrointestinal endoscopy (ESGE) guidelines. Gut 2016;65:374–89.

28 Acosta RD, Abraham NS, et al, ASGE Standards of Practice Committee. The management of antithrombotic agents for patients undergoing Gi endoscopy. Gastrointest Endosc 2016;83:3–16.

29 Pimenta-Melo AR, Monteiro-¬Soares M, Libânio D, et al. Missing rate for gastric cancer during upper gastrointestinal endoscopy. Eur J Gastroenterol Hepatol 2016;28:1041–9.

30 Kobayashi M, Sato Y, Terai S. Endoscopic surveillance of gastric cancers after Helicobacter pylori eradication. World J Gastroenterol 2015;21:10553.

31 Banks M, Graham D, Jansen M, et al. British Society of gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma. Gut 2019;68:1545–75.

32 Pimentel-¬Nunes P, Libânio D, Marcos-Pinto R, et al. Management of epithelial precancerous conditions and lesions in the stomach (maps II): European Society of gastrointestinal endoscopy (ESGE), European Helicobacter and microbiota Study Group (EHMSG), European Society of pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019. Endoscopy 2019;51:365–88.

33 Tajiri H, Niwa H. Proposal for a consensus terminology in endoscopy: how should different endoscopic imaging techniques be grouped and defined? Endoscopy 2008;40:775–8.

34 Kato M, Kaise M, Yonezawa J, et al. Autofluorescence endoscopy versus conventional white light endoscopy for the detection of superficial gastric neoplasia: a prospective comparative study. Endoscopy 2007;39:937–41.

35 Dohi O, Yagi N, Naito Y, et al. Blue laser imaging-bright improves the real-time detection rate of early gastric cancer: a randomized controlled study. Gastrointest Endosc 2019;89:47–57.

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