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Interferon-gamma and barrier function of keratinocytes mediate internalization of Staphylococcus aureus derived from atopic dermatitis

三宅 瑠 広島大学

2021.03.23

概要

In patients with atopic dermatitis (AD), the epidermal bacterial flora is disrupted,
and Staphylococcus aureus (S. aureus) is frequently detected in the skin. Bacterial
flora in the skin plays an important role in skin homeostasis. It has been shown that
changes in the flora lead to changes in skin cytokine environment and that loss of
flora diversity leads to AD-like dermatitis. S. aureus is rarely detected in healthy
individuals. It has been reported that S. ...

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参考文献

Amano, Wataru et al. 2015. “The Janus Kinase Inhibitor JTE-052 Improves Skin

Barrier Function through Suppressing Signal Transducer and Activator of

Transcription 3 Signaling.” Journal of Allergy and Clinical Immunology

136(3): 667-677.e7. http://dx.doi.org/10.1016/j.jaci.2015.03.051.

Beck, Lisa A. et al. 2014. “Dupilumab Treatment in Adults with Moderate-toSevere Atopic Dermatitis.” New England Journal of Medicine 371(2): 130–39.

Belkaid, Yasmine et al. 2017. “Staphylococcus Aureus and Staphylococcus

Epidermidis Strain Diversity Underlying Pediatric Atopic Dermatitis .”

Science Translational Medicine 9(397): eaal4651.

Callewaert, Chris et al. 2019. “IL-4Rα Blockade by Dupilumab Decreases

Staphylococcus Aureus Colonization and Increases Microbial Diversity in

Atopic Dermatitis.” Journal of Investigative Dermatology.

https://doi.org/10.1016/j.jid.2019.05.024.

Campbell, D. E., and A. S. Kemp. 1997. “Proliferation and Production of InterferonGamma (IFN-) and IL-4 in Response to Staphylococcus Aureus and

Staphylococcal Superantigen in Childhood Atopic Dermatitis.” Clinical and

Experimental Immunology 107(2): 392–97.

Cho, Sang Hyun et al. 2001. “Preferential Binding of Staphylococcus Aureus to

Skin Sites of Th2-Mediated Inflammation in a Murine Model.” Journal of

Investigative Dermatology 116(5): 658–63. http://dx.doi.org/10.1046/j.0022202x.2001.01331.x.

Clausen, M. L. et al. 2017. “Staphylococcus Aureus Colonization in Atopic Eczema

46

and Its Association with Filaggrin Gene Mutations.” British Journal of

Dermatology 177(5): 1394–1400.

Deckers, Ivette A.G. et al. 2012. “Investigating International Time Trends in the

Incidence and Prevalence of Atopic Eczema 1990-2010: A Systematic Review of

Epidemiological Studies.” PLoS ONE 7(7).

Drislane, Catherine, and Alan D. Irvine. 2020. “The Role of Filaggrin in Atopic

Dermatitis and Allergic Disease.” Annals of Allergy, Asthma and Immunology

124(1): 36–43. http://dx.doi.org/10.1016/j.anai.2019.10.008.

van Drongelen, V. et al. 2014. “Reduced Filaggrin Expression Is Accompanied by

Increased Staphylococcus Aureus Colonization of Epidermal Skin Models.”

Clinical and Experimental Allergy 44(12): 1515–24.

Fleury, Orla M et al. 2017. “Clumping Factor B Promotes Adherence of

Staphylococcus Aureus to Corneocytes in Atopic Dermatitis.” 85(6): 1–12.

Fowler, Trent et al. 2000. “Cellular Invasion by Staphylococcus Aureus Involves a

Fibronectin Bridge between the Bacterial Fibronectic-Binding MSCRAMMs

and Host Cell Β1 Integrins.” European Journal of Cell Biology 79(10): 672–79.

Fujitsu, Youichiro, Ken Fukuda, Naoki Kumagai, and Teruo Nishida. 2003. “IL-4Induced Cell Proliferation and Production of Extracellular Matrix Proteins in

Human Conjunctival Fibroblasts.” Experimental Eye Research 76(1): 107–14.

Furue, Masutaka. 2020. “Regulation of Filaggrin, Loricrin, and Involucrin by IL-4,

IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic

Dermatitis.” International Journal of Molecular Sciences 21(15): 1–25.

Gallo, Richard L., and Teruaki Nakatsuji. 2011. “Microbial Symbiosis with the

Innate Immune Defense System of the Skin.” Journal of Investigative

47

Dermatology 131(10): 1974–80. http://dx.doi.org/10.1038/jid.2011.182.

Gittler, Julia K. et al. 2012. “Progressive Activation of TH2/TH22 Cytokines and

Selective Epidermal Proteins Characterizes Acute and Chronic Atopic

Dermatitis.” Journal of Allergy and Clinical Immunology 130(6): 1344–54.

Groves, Richard W., Hitoshi Mizutani, J. David Kieffer, and Thomas S. Kupper.

1995. “Inflammatory Skin Disease in Transgenic Mice That Express High

Levels of Interleukin 1α in Basal Epidermis.” Proceedings of the National

Academy of Sciences of the United States of America 92(25): 11874–78.

Gutowska-Owsiak, Danuta et al. 2018. “Orchestrated Control of Filaggrin-Actin

Scaffolds Underpins Cornification.” Cell Death and Disease 9(4).

http://dx.doi.org/10.1038/s41419-018-0407-2.

Guzik, Tomasz J. et al. 2005. “Persistent Skin Colonization with Staphylococcus

Aureus in Atopic Dermatitis: Relationship to Clinical and Immunological

Parameters.” Clinical and Experimental Allergy 35(4): 448–55.

Harkins, Catriona P. et al. 2018. “The Microevolution and Epidemiology of

Staphylococcus Aureus Colonization during Atopic Eczema Disease Flare.”

Journal of Investigative Dermatology 138(2): 336–43.

Hayashida, Sayaka et al. 2010. “Are Lifetime Prevalence of Impetigo, Molluscum

and Herpes Infection Really Increased in Children Having Atopic Dermatitis?”

Journal of Dermatological Science 60(3): 173–78.

http://dx.doi.org/10.1016/j.jdermsci.2010.09.003.

Higaki, Shuichi, Masaaki Morohashi, Takayoshi Yamagishi, and Yoshinori

Hasegawa. 1999. “Comparative Study of Staphylococci from the Skin of Atopic

Dermatitis Patients and from Healthy Subjects.” International Journal of

48

Dermatology 38(4): 265–69.

Howell, Michael D. et al. 2009. “Cytokine Modulation of Atopic Dermatitis

Filaggrin Skin Expression.” Journal of Allergy and Clinical Immunology 124(3

SUPPL. 2): 7–12.

Irvine, Alan D., W. H.Irwin McLean, and Donald Y.M. Leung. 2011. “Filaggrin

Mutations Associated with Skin and Allergic Diseases.” New England Journal

of Medicine 365(14): 1315–27.

Iwamoto, Kazumasa et al. 2017. “Staphylococcus Aureus from Atopic Dermatitis

Skin Alters Cytokine Production Triggered by Monocyte-Derived Langerhans

Cell.” Journal of Dermatological Science 88(3): 271–79.

http://dx.doi.org/10.1016/j.jdermsci.2017.08.001.

Iwamoto, Kazumasa, Masaya Moriwaki, Ryu Miyake, and Michihiro Hide. 2019.

“Staphylococcus Aureus in Atopic Dermatitis: Strain-Specific Cell Wall

Proteins and Skin Immunity.” Allergology International 68(3): 309–15.

https://doi.org/10.1016/j.alit.2019.02.006.

Josse, Jérôme, Frédéric Laurent, and Alan Diot. 2017. “Staphylococcal Adhesion

and Host Cell Invasion: Fibronectin-Binding and Other Mechanisms.”

Frontiers in Microbiology 8(DEC): 1–8.

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02433/full.

Kezic, Sanja et al. 2012. “Filaggrin Loss-of-Function Mutations Are Associated with

Enhanced Expression of IL-1 Cytokines in the Stratum Corneum of Patients

with Atopic Dermatitis and in a Murine Model of Filaggrin Deficiency.”

Journal of Allergy and Clinical Immunology 129(4): 1031–40.

Al Kindi, Arwa et al. 2019. “Staphylococcus Aureus Internalized by Skin

49

Keratinocytes Evade Antibiotic Killing.” Frontiers in Microbiology 10(SEP): 1–

10.

Kobayashi, Tetsuro et al. 2015. “Dysbiosis and Staphyloccus Aureus Colonization

Drives Inflammation in Atopic Dermatitis.” Immunity 42(4): 756–66.

http://dx.doi.org/10.1016/j.immuni.2015.03.014.

Kong, Heidi H. et al. 2012. “Temporal Shifts in the Skin Microbiome Associated

with Disease Flares and Treatment in Children with Atopic Dermatitis.”

Genome Research 22(5): 850–59.

Laborel-Préneron, Emeline et al. 2015. “Effects of the Staphylococcus Aureus and

Staphylococcus Epidermidis Secretomes Isolated from the Skin Microbiota of

Atopic Children on CD4+ T Cell Activation.” PLoS ONE 10(10).

McCoy, Kathy D., Aline Ignacio, and Markus B. Geuking. 2018. “Microbiota and

Type 2 Immune Responses.” Current Opinion in Immunology 54: 20–27.

https://doi.org/10.1016/j.coi.2018.05.009.

Miajlovic, Helen, Padraic G. Fallon, Alan D. Irvine, and Timothy J. Foster. 2010.

“Effect of Filaggrin Breakdown Products on Growth of and Protein Expression

by Staphylococcus Aureus.” Journal of Allergy and Clinical Immunology

126(6): 1184-1190.e3. http://dx.doi.org/10.1016/j.jaci.2010.09.015.

Miller, Lloyd S., and John S. Cho. 2011. “Immunity against Staphylococcus Aureus

Cutaneous Infections.” Nature Reviews Immunology 11(8): 505–18.

Miller, Loren G. et al. 2015. “Staphylococcus Aureus Skin Infection Recurrences

among Household Members: An Examination of Host, Behavioral, and

Pathogen-Level Predictors.” Clinical Infectious Diseases 60(5): 753–63.

Moriwaki, Masaya et al. 2019. “Staphylococcus Aureus from Atopic Dermatitis

50

Skin Accumulates in the Lysosomes of Keratinocytes with Induction of IL-1α

Secretion via TLR9.” Allergy 74(3): 560–71.

http://doi.wiley.com/10.1111/all.13622.

Naik, Shruti et al. 2013. “Compartmentalized Control of Skin Immunity by

Resident Commensals.” 337(6098): 1115–19.

Nakatsuji, Teruaki et al. 2017. “Antimicrobials from Human Skin Commensal

Bacteria Protect against Staphylococcus Aureus and Are Deficient in Atopic

Dermatitis.” Science Translational Medicine 9(378): 1–12.

Olaru, Florina, and Liselotte E. Jensen. 2010. “Staphylococcus Aureus Stimulates

Neutrophil Targeting Chemokine Expression in Keratinocytes through an

Autocrine IL-1α Signaling Loop.” Journal of Investigative Dermatology 130(7):

1866–76. http://dx.doi.org/10.1038/jid.2010.37.

Van Den Oord, Rosanne A.H.M., and Aziz Sheikh. 2009. “Filaggrin Gene Defects

and Risk of Developing Allergic Sensitisation and Allergic Disorders:

Systematic Review and Meta-Analysis.” BMJ (Online) 339(7712): 86–88.

Palmer, Colin N.A. et al. 2006. “Common Loss-of-Function Variants of the

Epidermal Barrier Protein Filaggrin Are a Major Predisposing Factor for

Atopic Dermatitis.” Nature Genetics 38(4): 441–46.

Parlet, Corey P., Morgan M. Brown, and Alexander R. Horswill. 2019. “Commensal

Staphylococci Influence Staphylococcus Aureus Skin Colonization and

Disease.” Trends in Microbiology 27(6): 497–507.

https://doi.org/10.1016/j.tim.2019.01.008.

Pendaries, Valérie et al. 2014. “Knockdown of Filaggrin in a Three-Dimensional

Reconstructed Human Epidermis Impairs Keratinocyte Differentiation.”

51

Journal of Investigative Dermatology 134(12): 2938–46.

Postlethwaite, Arnold E., Maureen A. Holness, Hitoshi Katai, and Rajendra

Raghow. 1992. “Human Fibroblasts Synthesize Elevated Levels of

Extracellular Matrix Proteins in Response to Interleukin 4.” Journal of

Clinical Investigation 90(4): 1479–85.

Rodríguez, Elke et al. 2009. “Meta-Analysis of Filaggrin Polymorphisms in Eczema

and Asthma: Robust Risk Factors in Atopic Disease.” Journal of Allergy and

Clinical Immunology 123(6).

Rojo, A. et al. 2014. “Staphylococcus Aureus Genomic Pattern and Atopic

Dermatitis: May Factors Other than Superantigens Be Involved?” European

Journal of Clinical Microbiology and Infectious Diseases 33(4): 651–58.

Seo, Min Duk et al. 2012. “HaCa T Keratinocytes and Primary Epidermal

Keratinocytes Have Different Transcriptional Profiles of Cornified EnvelopeAssociated Genes to T Helper Cell Cytokines.” Biomolecules and Therapeutics

20(2): 171–76.

Serezani, Ana P.M. et al. 2017. “IL-4 Impairs Wound Healing Potential in the Skin

by Repressing Fibronectin Expression.” Journal of Allergy and Clinical

Immunology 139(1): 142-151.e5. http://dx.doi.org/10.1016/j.jaci.2016.07.012.

Sinha, Bhanu et al. 1999. “Fibronectin-Binding Protein Acts as Staphylococcus

Aureus Invasin via Fibronectin Bridging to Integrin Α5β1.” Cellular

Microbiology 1(2): 101–17.

Totté, J. E.E. et al. 2016. “Prevalence and Odds of Staphylococcus Aureus Carriage

in Atopic Dermatitis: A Systematic Review and Meta-Analysis.” British

Journal of Dermatology 175(4): 687–95.

52

Volz, Thomas et al. 2018. “Induction of IL-10-Balanced Immune Profiles Following

Exposure to LTA from Staphylococcus Epidermidis.” Experimental

Dermatology 27(4): 318–26.

Weidinger, Stephan et al. 2006. “Loss-of-Function Variations within the Filaggrin

Gene Predispose for Atopic Dermatitis with Allergic Sensitizations.” Journal of

Allergy and Clinical Immunology 118(1): 214–19.

———. 2018. “Atopic Dermatitis.” Nature Reviews Disease Primers 4(1): 1.

http://www.nature.com/articles/s41572-018-0001-z.

Welch, Pamela A. et al. 2018. “First-in-Human Topical Microbiome

Transplantation with Roseomonas Mucosa for Atopic Dermatitis.” JCI Insight

3(9).

Yeung, Melinda et al. 2011. “Identification of Major Clonal Complexes and Toxin

Producing Strains among Staphylococcus Aureus Associated with Atopic

Dermatitis.” Microbes and Infection 13(2): 189–97.

http://dx.doi.org/10.1016/j.micinf.2010.10.023.

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謝辞

本研究は、主指導教員の酒井規雄教授、副指導教員の秀道広教授、田中茂講師、なら

びに共同研究者である岩本和真先生、菅井基行先生、田中暁生准教授の御指導の下に行

われました。先生方の丁寧かつ熱心な御指導に心より深く感謝申し上げます。また、セ

ミナーや実験手法等で貴重なご意見、ご協力を頂いた神経薬理学教室、皮膚科学教室の

皆様に御礼申し上げます。

54

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