1 Mulukutla BC, Yongky A, Le T, Mashek DG, et al. Regulation of Glucose Metabolism - A Perspective From Cell Bioprocessing. Trends Biotechnol. 2016;34(8):638-651.
2 Momcilovic M, Bailey ST, Lee JT, et al. The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. Cancer Cell. 2018;33:905-921.
3 Goodwin J, Neugent ML, Lee SY, et al. The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nat Commun. 2017;8:15503.
4 Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J Gen Physiol. 1927;8:519-30.
5 Maria L, Jason L. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016; 41(3): 211–218.
6 Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: Relevance Warburg hypothesis and beyond. Pharmacol Ther. 2009;121:29-40.
7 Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer. 2011;11:85-95.
8 Ralph JD, Navdeep SC. Fundamentals of cancer metabolism. Sci Adv. 2016;2(5)
9 Kami K, Fujimori T, Sato H, et al. Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry. Metabolomics. 2013;9:444-453.
10 Hirayama A, Kami K, Sugimoto M, et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 2009;69:4918-25.
11 Gade TPF, Tucker E, Nakazawa MS, et al. Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma. Radiology. 2017;283(3):702-710
12 Kimmelman AC and White E. Autophagy and Tumor Metabolism. Cell Metab. 2017;25:1037-1043.
13 Guo JY and White E. Autophagy, Metabolism, and Cancer. Cold Spring Harb Symp Quant Biol. 2016;81:73-78.
14 Mizushima N and Komatsu M. Autophagy: Renovation of Cells and Tissues. Cell. 2011;147:728-41.
15 Rosenfeldt MT, O'Prey J, Morton JP, et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature. 2013;504:296–300.
16 Yue Z, Jin S, Yang C, et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA. 2003:100:15077-82.
17 Liang XH, Jackson S, Seaman M, et al. Induction of autophagy and inhibition of t umorigenesis by beclin 1. Nature. 1999;402:672-6.
18 Guo JY, Karsli-Uzunbas G, Mathew R, et al. Autophagy suppresses progression of K-ras- induced lung tumors to oncocytomas and maintains lipid homeostasis. Genes Dev. 2013;27:1447-61.
19 Strohecker AM, Guo JY, Karsli-Uzunbas G, et al. Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of BRAFV600E–Driven Lung Tumors. Cancer Discov. 2013;3:1272-85.
20 Karsli-Uzunbas G, Guo JY, Price S, et al. Autophagy is required for Glucose Homeostasis and Lung Tumor Maintenance. Cancer Discov. 2014;4:914-27.
21 Park TJ, Reznick J, Peterson BL, et al. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat. Science. 2017;356:307-311.
22 Atkinson DE. The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry. 1968;7(11):4030-4.
23 Giuliani A. The application of principal component analysis to drug discovery and biomedical data. Drug Discov Today. 2017;22:1069-1076.
24 Ganapathy-Kanniappan S, Geschwind JF. Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol Cancer. 2013;3;12:152.
25 Yang L, Venneti S, Nagrath D. Glutaminolysis: A Hallmark of Cancer Metabolism. Annu Rev Biomed Eng. 2017;21;19:163-194.
26 Faubert B, Li KY, Cai L, et al. Lactate Metabolism in Human Lung Tumors. Cell. 2017;171:358-371..
27 Hensley CT, Faubert B, Yuan Q, et al. Metabolic Heterogeneity in Human Lung Tumors. Cell. 2016;164:681-94.
28 Guillot L, Nathan N, Tabary O, et al. Alveolar epithelial cells: master regulators of lung homeostasis. Int J Biochem Cell Biol. 2013;45:2568-73.
29 De PR, Lerut TE, Schreinemakers HH, et al. Effect of inflation on adenosine triphosphate catabolism and lactate production during normothermic lung ischemia. Ann Thorac Surg. 1993;55:1073-8
30 Lin HH, Chung Y, Cheng CT. Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis. Autophagy. 2018;14(9):1481-1498.
31 Guo JY, Teng X., Laddha SV, et al. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016;30:1704-17.
32 da Cunha Santos G, Shepherd FA, Tsao MS. EGFR mutations and lung cancer. Annu Rev Pathol. 2011;6:49-69
33 Li H, You L, Xie J, et al. The roles of subcellularly located EGFR in autophagy. Cell Signal. 2017;35:223-230.
34 Tang ZH, Cao WX, Su MX, et al. Osimertinib induces autophagy and apoptosis via reactive oxygen species generation in non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2017;15;321:18-26.
35 Hsu HL, Liao PL, Cheng YW, et al. Chloramphenicol Induces Autophagy and Inhibits the Hypoxia Inducible Factor-1 Alpha Pathway in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019;3;20(1).
36 Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Nat Rev Cancer. 2017;17(9): 528–542.
37 Sotelo J1, Briceño E, López-González MA. Adding chloroquine to conventional treatment for glioblastoma multiforme: a randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2006;7;144:337-43.
38 Sarah BG, Jeffrey GS, Joel WN, et al. A Phase I Study of Erlotinib and Hydroxychloroquine in Advanced Non-Small Cell Lung Cancer. J Thorac Oncol. 2012;7:1602–1608.
39 Romero R, Sayin VI, Davidson SM, et al. Keap1 loss promotes Kras-driven lung cancer and results in a dependence on glutaminolysis. Nat Med. 2017; 23:1362–1368.
40 Ciborowski M, Kisluk J, Pietrowska K, et al. Development of LC-QTOF-MS method for human lung tissue fingerprinting. A preliminary application to nonsmall cell lung cancer. Electrophoresis. 2017;38:2304-2312.
論文の公開元へ
