リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「エネルギー代謝におけるGタンパク質共役型受容体(GPCR)シグナルの重要性」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

エネルギー代謝におけるGタンパク質共役型受容体(GPCR)シグナルの重要性

木村, 岳史 信州大学

2022.08.19

概要

肥満と糖尿病の罹患率は,先進国だけでなく新興国を含め世界的に増加している。インスリンの発見から100年,現代医学の進歩により様々な薬物治療が開発されてきたが,肥満や糖尿病の解決にはより効果的な治療が必要である。Gタンパク質共役型受容体(GPCR)は,肥満,糖尿病,肝疾患,神経疾患,癌など様々な慢性疾患に対する重要な創薬ターゲットとして注目されている。過去20年間,世界中の多くの研究室が,糖代謝やエネルギー恒常性の制御におけるGPCRシグナルの役割の解明に注力してきた。これらの研究から得られた情報は,肥満や糖尿病における新規治療薬の開発に重要な指針となると考えられる。本総説では,肝臓,膵臓,骨格筋,脂肪組織などの全身のエネルギー代謝に重要な組織における,代表的なGPCRシグナルについて要約する。

参考文献

1) Wang L, Pydi SP, Zhu L, et al : Adipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity. Nat Commun 11 : 2995, 2020

2) Tanaka N, Kimura T, Fujimori N, et al : Current status, problems, and perspectives of non-alcoholic fatty liver disease research. World J Gastroenterol 25 : 163-177, 2019

3) Kimura T, Namkoong H : Susceptibility of the obese population to COVID-19. Int J Infect Dis 101 : 380-381, 2020

4) Roden M, Shulman GI : The integrative biology of type 2 diabetes. Nature 576 : 51-60, 2019

5) Kimura T, Pydi SP, Pham J, et al : Metabolic Functions of G Protein-Coupled Receptors in Hepatocytes-Potential Applications for Diabetes and NAFLD. Biomolecules 10, 2020

6) Pydi SP, Jain S, Barella LF, et al : beta-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia. Sci Adv 6 : eaba1733, 2020

7) Barella LF, Jain S, Kimura T, et al : Metabolic roles of G protein-coupled receptor signaling in obesity and type 2 diabetes. FEBS J 288 : 2622-2644, 2021

8) Wang L, Zhu L, Meister J, et al : Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs. Annu Rev Pharmacol Toxicol 61 : 421-440, 2021

9) Reimann F, Gribble FM : G protein-coupled receptors as new therapeutic targets for type 2 diabetes. Diabetologia 59 : 229-233, 2016

10) Lamont BJ, Li Y, Kwan E, et al : Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice. J Clin Invest 122 : 388-402, 2012

11) Ackeifi C, Wang P, Karakose E, et al : GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human beta cell regeneration. Sci Transl Med 12, 2020

12) Barella LF, Rossi M, Pydi SP, et al : beta-Arrestin-1 is required for adaptive beta-cell mass expansion during obesity. Nat Commun 12 : 3385, 2021

13) Zhu L, Dattaroy D, Pham J, et al : Intra-islet glucagon signaling is critical for maintaining glucose homeostasis. JCI Insight 5, 2019

14) Exton JH : Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36 : 481-509, 1996

15) Ueno H, Ito R, Abe SI, et al : SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity. J Pharmacol Exp Ther 370 : 172-181, 2019

16) Kaku K, Enya K, Nakaya R, et al : Long-term safety and efficacy of fasiglifam (TAK-875), a G-protein-coupled receptor 40 agonist, as monotherapy and combination therapy in Japanese patients with type 2 diabetes : a 52-week open-label phase III study. Diabetes Obes Metab 18 : 925-929, 2016

17) Oh DY, Walenta E, Akiyama TE, et al : A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med 20 : 942-947, 2014

18) Stone VM, Dhayal S, Brocklehurst KJ, et al : GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia 57 : 1182-1191, 2014

19) Kimura T, Singh S, Tanaka N, et al : Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease. Front Endocrinol (Lausanne) 12 : 773432, 2021

20) Ozcan L, Wong CC, Li G, et al : Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab 15 : 739-751, 2012

21) Boland ML, Laker RC, Mather K, et al : Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis. Nat Metab 2 : 413-431, 2020

22) Khan SA, Sathyanarayan A, Mashek MT, et al : ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1alpha/ PPAR-alpha signaling. Diabetes 64 : 418-426, 2015

23) Rossi M, Zhu L, McMillin SM, et al : Hepatic Gi signaling regulates whole-body glucose homeostasis. J Clin Invest 128 : 746-759, 2018

24) Gonzalez-Benitez E, Guinzberg R, Diaz-Cruz A, et al : Regulation of glycogen metabolism in hepatocytes through adenosine receptors. Role of Ca2+ and cAMP. Eur J Pharmacol 437 : 105-111, 2002

25) Jacobson KA, Tosh DK, Jain S, et al : Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development. Front Cell Neurosci 13 : 124, 2019

26) Li JH, Jain S, McMillin SM, et al : A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology 154 : 3539-3551, 2013

27) Ding C, Leow MK, Magkos F : Oxytocin in metabolic homeostasis : implications for obesity and diabetes management. Obes Rev 20 : 22-40, 2019

28) Kang S, Huang J, Lee BK, et al : Omega-3 polyunsaturated fatty acids protect human hepatoma cells from developing steatosis through FFA4 (GPR120). Biochim Biophys Acta Mol Cell Biol Lipids 1863 : 105-116, 2018

29) On S, Kim HY, Kim HS, et al : Involvement of G-Protein-Coupled Receptor 40 in the Inhibitory Effects of Docosa hexaenoic Acid on SREBP1-Mediated Lipogenic Enzyme Expression in Primary Hepatocytes. Int J Mol Sci 20, 2019

30) DeFronzo RA, Gunnarsson R, Bjorkman O, et al : Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76 : 149-155, 1985

31) Merlin J, Evans BA, Csikasz RI, et al : The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism. Cell Signal 22 : 1104-1113, 2010

32) Bone DBJ, Meister J, Knudsen JR, et al : Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis. Diabetes 68 : 1341-1352, 2019

33) Jain S, Pydi SP, Toti KS, et al : Lack of adipocyte purinergic P2Y6 receptor greatly improves whole body glucose homeostasis. Proc Natl Acad Sci U S A 117 : 30763-30774, 2020

34) Sato M, Dehvari N, Oberg AI, et al : Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle. Diabetes 63 : 4115-4129, 2014

35) Gnad T, Navarro G, Lahesmaa M, et al : Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity. Cell Metab 32 : 56-70 e57, 2020

36) Simoneau JA, Kelley DE : Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol (1985) 83 : 166-171, 1997

37) Koo JH, Kim TH, Park SY, et al : Galpha13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism. J Clin Invest 127 : 3845-3860, 2017

38) Pydi SP, Jain S, Tung W, et al : Adipocyte beta-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis. Nat Commun 10 : 2936, 2019

39) Cypess AM, Weiner LS, Roberts-Toler C, et al : Activation of human brown adipose tissue by a beta3-adrenergic receptor agonist. Cell Metab 21 : 33-38, 2015

40) O’Mara AE, Johnson JW, Linderman JD, et al : Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. J Clin Invest 130 : 2209-2219, 2020

41) Finlin BS, Memetimin H, Zhu B, et al : The beta3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. J Clin Invest 130 : 2319-2331, 2020

42) Lockie SH, Heppner KM, Chaudhary N, et al : Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes 61 : 2753-2762, 2012

43) Johansson SM, Lindgren E, Yang JN, et al : Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue-interactions with insulin. Eur J Pharmacol 597 : 92-101, 2008

44) Pfeifer A, Hoffmann LS : Brown, beige, and white : the new color code of fat and its pharmacological implications. Annu Rev Pharmacol Toxicol 55 : 207-227, 2015

45) Silvestri C, Di Marzo V : The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Cell Metab 17 : 475-490, 2013

46) Kimura T, Pydi SP, Wang L, et al : Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice. Nat Commun 13 : 1652, 2022

47) Kang NY, Soetedjo AAP, Amirruddin NS, et al : Tools for Bioimaging Pancreatic beta Cells in Diabetes. Trends Mol Med 25 : 708-722, 2019

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る