Discovery of New Cytotoxic Aplaminone Derivatives from the Sea Hare Aplysia kurodai and Elucidation of Their Accumulation from Local Sea Algae through the Food Chain

概要

Marine invertebrates are known to be a rich source of
biologically active substances, and many isolation studies have
supported this fact.[1–4] Aplysia kurodai, a common Japanese
herbivorous mollusk that is also referred to as sea hare, has been
investigated since the 1960s in an attempt to discover structurally
and biologically interesting compounds. [5,6] In the 1990s, Kigoshi
and co-workers isolated highly cytotoxic alkaloids aplaminone (1,
1.6 × 10−4% yield based on wet wt, same as below) and
neoaplaminone (2, 2.4 × 10−5%), two bromodopamine analogs
with an oxygenated C15 chain (Figure 1). ...

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