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Zwitterionic polymers and microfabricated culture devices for hair regenerative medicine

鈴木 康平 横浜国立大学 DOI:info:doi/10.18880/00014821

2022.11.24

概要

再生医療とは、幹細胞等を用いて、臓器や組織の欠損や機能障害・不全に対し、それらの臓器や組織を再生し、失われた人体機能の回復を目指す医療である。既存の医薬品では治療が難しいものや、治療法が確立されていない疾患に対して新たな治療法となる可能性が期待されている[1]。

　なかでもiPS細胞やES細胞などの多能性幹細胞や、間葉系幹細胞や造血幹細胞などの体性幹細胞を用いた研究開発、実用化が進められている。表1-1に示すようにジャパン・ティッシュ・エンジニアリング社の皮膚再生シートのジェイスを初めとし、国内で様々な再生医療等製品が承認されている(令和2年9月時点)[2]。

　ここで再生医療等製品を作製するための1つの流れとして図1-1に示すように『幹細胞の増殖⇒目的細胞への分化誘導⇒三次元組織の形成⇒移植』が挙げられる。

　この中で三次元組織化が1つのポイントとされる。シングル細胞を移植した場合、細胞は移植部位への生着率が低いことが課題とされる。一方でシングル細胞が三次元組織化した細胞シートや細胞凝集塊を用いた場合、移植時の組織への生着率が向上することが知られている[3]。その他にも三次元組織は二次元組織と比較し、細胞の増殖が促進され、治療能力や、生存率、薬物代謝性がin vivoの細胞機能と近くなることが示されている（図1-2）[4]。そのためがん研究、薬剤スクリーニング、組織構築などの幅広い分野で盛んに応用されている。

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参考文献

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第四章

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