1.
Makuuchi M, Kosuge T, Takayama T, Yamazaki S, Kakazu T, Miyagawa S, Kawasaki S. Surgery
for small liver cancers. Seminars in Surgical Oncology. 9:298-304,1993
2.
Belghiti J, Hiramatsu K, Benoist S, Massault P, Sauvanet A, Farges O. Seven hundred forty-
seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection. Journal
of the American College of Surgeons. 191:38-46,2000.
3.
Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S,
Blumgart LH. Improvement in perioperative outcome after hepatic resection: analysis of 1,803
consecutive cases over the past decade. Annals of surgery. 236:397-406; discussion 406-
397,2002.
4.
Imamura H, Seyama Y, Kokudo N, Maema A, Sugawara Y, Sano K, Takayama T, Makuuchi M.
One thousand fifty-six hepatectomies without mortality in 8 years. Archives of surgery (Chicago,
Ill : 1960). 138:1198-1206; discussion 1206,2003.
5.
Alkozai EM, Lisman T, Porte RJ. Bleeding in liver surgery: prevention and treatment. Clinics in
liver disease. 13:145-154,2009.
6.
Makuuchi M, Thai BL, Takayasu K, Takayama T, Kosuge T, Gunven P, Yamazaki S, Hasegawa
H, Ozaki H. Preoperative portal embolization to increase safety of major hepatectomy for hilar
bile duct carcinoma: a preliminary report. Surgery. 107:521-527,1990.
56
7.
Kubota K, Makuuchi M, Kusaka K, Kobayashi T, Miki K, Hasegawa K, Harihara Y, Takayama
T. Measurement of liver volume and hepatic functional reserve as a guide to decision-making in
resectional surgery for hepatic tumors. Hepatology (Baltimore, Md). 26:1176-1181,1997.
8.
崇正 竜, 明浩 趙 著 肝臓の外科解剖―門脈segmentationに基づく新たな
肝区域の考え方, 医学書院, 2004.
9.
Mise Y, Hasegawa K, Satou S, Aoki T, Beck Y, Sugawara Y, Makuuchi M, Kokudo N. Venous
reconstruction based on virtual liver resection to avoid congestion in the liver remnant. The
British journal of surgery. 98:1742-1751,2011.
10.
Mise Y, Hasegawa K, Satou S, Shindoh J, Miki K, Akamatsu N, Arita J, Kaneko J, Sakamoto Y,
Kokudo N. How Has Virtual Hepatectomy Changed the Practice of Liver Surgery?: Experience
of 1194 Virtual Hepatectomy Before Liver Resection and Living Donor Liver Transplantation.
Annals of surgery. 268:127-133,2018.
11.
Takamoto T, Hashimoto T, Ogata S, Inoue K, Maruyama Y, Miyazaki A, Makuuchi M. Planning
of anatomical liver segmentectomy and subsegmentectomy with 3-dimensional simulation
software. American journal of surgery. 206:530-538,2013.
12.
Nakayama K, Oshiro Y, Miyamoto R, Kohno K, Fukunaga K, Ohkohchi N. The Effect of Three-
Dimensional Preoperative Simulation on Liver Surgery. World journal of surgery. 41:1840-
1847,2017.
57
13.
Satou S, Aoki T, Kaneko J, Sakamoto Y, Hasegawa K, Sugawara Y, Arai O, Mitake T, Miura K,
Kokudo N. Initial experience of intraoperative three-dimensional navigation for liver resection
using real-time virtual sonography. Surgery. 155:255-262,2014.
14.
Makuuchi M, Hasegawa H, Yamazaki S. Intraoperative ultrasonic examination for hepatectomy.
Ultrasound in medicine & biology. Suppl 2:493-497,1983.
15.
Makuuchi M, Hasegawa H, Yamazaki S. Ultrasonically guided subsegmentectomy. Surgery,
gynecology & obstetrics. 161:346-350,1985.
16.
Hasegawa K, Kokudo N, Imamura H, Matsuyama Y, Aoki T, Minagawa M, Sano K, Sugawara Y,
Takayama T, Makuuchi M. Prognostic impact of anatomic resection for hepatocellular
carcinoma. Annals of surgery. 242:252-259,2005.
17.
Shindoh J, Hasegawa K, Inoue Y, Ishizawa T, Nagata R, Aoki T, Sakamoto Y, Sugawara Y,
Makuuchi M, Kokudo N. Risk factors of post-operative recurrence and adequate surgical
approach to improve long-term outcomes of hepatocellular carcinoma. The Official Journal of
the International Hepato Pancreato Biliary Association. 15:31-39,2013.
18.
Lim C, Ishizawa T, Miyata A, Mise Y, Sakamoto Y, Hasegawa K, Sugawara Y, Kokudo N.
Surgical Indications and Procedures for Resection of Hepatic Malignancies Confined to Segment
VII. Annals of surgery. 263:529-537,2016.
19.
Arita J, Kokudo N, Zhang K, Makuuchi M. Three-dimensional visualization of liver segments on
58
contrast-enhanced intraoperative sonography. American journal of roentgenology. 188:W464-
466,2007.
20.
Shindoh J, Seyama Y, Umekita N. Three-dimensional staining of liver segments with an
ultrasound contrast agent as an aid to anatomic liver resection. Journal of the American College
of Surgeons. 215:e5-10,2012.
21.
Landsman ML, Kwant G, Mook GA, Zijlstra WG. Light-absorbing properties, stability, and
spectral stabilization of indocyanine green. Journal of applied physiology. 40:575-583,1976.
22.
Vahrmeijer AL, Hutteman M, van der Vorst JR, van de Velde CJ, Frangioni JV. Image-guided
cancer surgery using near-infrared fluorescence. Nature reviews Clinical oncology. 10:507-
518,2013.
23.
Motomura K, Inaji H, Komoike Y, Kasugai T, Noguchi S, Koyama H. Sentinel node biopsy
guided by indocyanine green dye in breast cancer patients. Japanese journal of clinical
oncology. 29:604-607,1999.
24.
Kawaguchi Y, Ishizawa T, Masuda K, Sato S, Kaneko J, Aoki T, Beck Y, Sugawara Y, Hasegawa
K, Kokudo N. Hepatobiliary surgery guided by a novel fluorescent imaging technique for
visualizing hepatic arteries, bile ducts, and liver cancers on color images. Journal of the
American College of Surgeons. 212:e33-39,2011.
25.
Ishizawa T, Tamura S, Masuda K, Aoki T, Hasegawa K, Imamura H, Beck Y, Kokudo N.
59
Intraoperative fluorescent cholangiography using indocyanine green: a biliary road map for safe
surgery. Journal of the American College of Surgeons. 208:e1-4,2009.
26.
Ishizawa T, Bandai Y, Ijichi M, Kaneko J, Hasegawa K, Kokudo N. Fluorescent cholangiography
illuminating the biliary tree during laparoscopic cholecystectomy. The British journal of surgery.
97:1369-1377,2010.
27.
Gotoh K, Yamada T, Ishikawa O, Takahashi H, Eguchi H, Yano M, Ohigashi H, Tomita Y,
Miyamoto Y, Imaoka S. A novel image-guided surgery of hepatocellular carcinoma by
indocyanine green fluorescence imaging navigation. Journal of surgical oncology. 100:75-
79,2009.
28.
Ishizawa T, Masuda K, Urano Y, Kawaguchi Y, Satou S, Kaneko J, Hasegawa K, Shibahara J,
Fukayama M, Tsuji S, Midorikawa Y, Aburatani H, Kokudo N. Mechanistic background and
clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma.
Annals of surgical oncology. 21:440-448,2014.
29.
Aoki T, Yasuda D, Shimizu Y, Odaira M, Niiya T, Kusano T, Mitamura K, Hayashi K, Murai N,
Koizumi T, Kato H, Enami Y, Miwa M, Kusano M. Image-guided liver mapping using
fluorescence navigation system with indocyanine green for anatomical hepatic resection. World
journal of surgery. 32:1763-1767,2008.
30.
Bismuth H, Castaing D, Garden OJ. The use of operative ultrasound in surgery of primary liver
60
tumors. World journal of surgery. 11:610-614,1987.
31.
Miyata A, Arita J, Shirata C, Abe S, Akamatsu N, Kaneko J, Kokudo N, Hasegawa K.
Quantitative Assessment of the Accuracy of Real-Time Virtual Sonography for Liver Surgery.
Surgical Innovation, 27: 60-67, 2020.
32.
Nakai M, Sato M, Sahara S, Takasaka I, Kawai N, Minamiguchi H, Tanihata H, Kimura M,
Takeuchi N. Radiofrequency ablation assisted by real-time virtual sonography and CT for
hepatocellular carcinoma undetectable by conventional sonography. Cardiovascular and
interventional radiology. 32:62-69,2009.
33.
Minami Y, Kitai S, Kudo M. Treatment response assessment of radiofrequency ablation for
hepatocellular carcinoma: usefulness of virtual CT sonography with magnetic navigation.
European journal of radiology. 81:e277-280,2012.
34.
Uematsu T, Takahashi K, Nishimura S, Watanabe J, Yamasaki S, Sugino T, Oishi T, Kakuda Y,
Sato M, Hayashi T. Real-time virtual sonography examination and biopsy for suspicious breast
lesions identified on MRI alone. European Radiology. 26;1064-1072,2016.
35.
Nakano S, Kousaka J, Fujii K, Yorozuya K, Yoshida M, Mouri Y, Akizuki M, Tetsuka R, Ando T,
Fukutomi T, Oshima Y, Kimura J, Ishiguchi T, Arai O. Impact of real-time virtual sonography, a
coordinated sonography and MRI system that uses an image fusion technique, on the
sonographic evaluation of MRI-detected lesions of the breast in second-look sonography. Breast
61
Cancer Research and Treatment. 134:1179-1188,2012.
36.
Uematsu T. Real-time virtual sonography (RVS)-guided vacuum-assisted breast biopsy for
lesions initially detected with breast MRI. Japanese Journal of Radiology. 31:826-831,2013.
37.
Ishizawa T, Zuker NB, Kokudo N, Gayet B. Positive and negative staining of hepatic segments by
use of fluorescent imaging techniques during laparoscopic hepatectomy. Archives of surgery
(Chicago, Ill : 1960). 147:393-394,2012.
38.
Takayama T, Makuuchi M, Watanabe K, Kosuge T, Takayasu K, Yamazaki S, Hasegawa H. A
new method for mapping hepatic subsegment: counterstaining identification technique. Surgery.
109:226-229,1991.
39.
Miyata A, Ishizawa T, Tani K, Shimizu A, Kaneko J, Aoki T, Sakamoto Y, Sugawara Y, Hasegawa
K, Kokudo N. Reappraisal of a Dye-Staining Technique for Anatomic Hepatectomy by the
Concomitant Use of Indocyanine Green Fluorescence Imaging. Journal of the American College
of Surgeons. 221:e27-36, 2015
40.
Kawaguchi Y, Ishizawa T, Miyata Y, Yamashita S, Masuda K, Satou S, Tamura S, Kaneko J,
Sakamoto Y, Aoki T, Hasegawa K, Sugawara Y, Kokudo N. Portal uptake function in veno-
occlusive regions evaluated by real-time fluorescent imaging using indocyanine green. Journal
of hepatology. 58:247-253,2013.
41.
Lethco EJ, Webb JM. The fate of FD&C blue no. 2 in rats. The Journal of pharmacology and
62
experimental therapeutics. 154:384-389,1966.
42.
Mitsuhashi N, Kimura F, Shimizu H, Imamaki M, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi
H, Nozawa S, Furukawa K, Takeuchi D, Takayashiki T, Suda K, Igarashi T, Miyazaki M.
Usefulness of intraoperative fluorescence imaging to evaluate local anatomy in hepatobiliary
surgery. Journal of hepato-biliary-pancreatic surgery. 15:508-514,2008.
43.
Inoue Y, Arita J, Sakamoto T, Ono Y, Takahashi M, Takahashi Y, Kokudo N, Saiura A.
Anatomical Liver Resections Guided by 3-Dimensional Parenchymal Staining Using Fusion
Indocyanine Green Fluorescence Imaging. Annals of surgery. 262:105-111,2015.
44.
Rodrigues EB, Meyer CH, Mennel S, Farah ME. Mechanisms of intravitreal toxicity of
indocyanine green dye: implications for chromovitrectomy. Retina (Philadelphia, Pa). 27:958-
970,2007.
45.
Speich R, Saesseli B, Hoffmann U, Neftel KA, Reichen J. Anaphylactoid reactions after
indocyanine-green administration. Annals of internal medicine. 109:345-346,1988.
46.
Chua TC, Saxena A, Liauw W, Kokandi A, Morris DL. Systematic review of randomized and
nonrandomized trials of the clinical response and outcomes of neoadjuvant systemic
chemotherapy for resectable colorectal liver metastases. Annals of surgical oncology. 17:492-
501,2010.
47.
Van Cutsem E, Cervantes A, Nordlinger B, Arnold D. Metastatic colorectal cancer: ESMO
63
Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 25
Suppl 3:iii1-9,2014.
48.
Takamoto T, Mise Y, Satou S, Kobayashi Y, Miura K, Saiura A, Hasegawa K, Kokudo N,
Makuuchi M. Feasibility of Intraoperative Navigation for Liver Resection Using Real-time
Virtual Sonography With Novel Automatic Registration System. World journal of surgery.
42:841-848,2018.
49.
Nishino H, Hatano E, Seo S, Nitta T, Saito T, Nakamura M, Hattori K, Takatani M, Fuji H, Taura
K, Uemoto S. Real-time Navigation for Liver Surgery Using Projection Mapping With
Indocyanine Green Fluorescence: Development of the Novel Medical Imaging Projection
System. Annals of surgery. 267:1134-1140,2018.
50.
Terasawa M, Ishizawa T, Mise Y, Inoue Y, Ito H, Takahashi Y, Saiura A. Applications of fusion-
fluorescence imaging using indocyanine green in laparoscopic hepatectomy. Surgical endoscopy.
31:5111-5118,2017.
51.
Matsui, Y, Terakawa, N, Satoi, S, Kaibori, M, Kitade, H, Takai, S, Kwon, A. H, Kamiyama, Y.
Postoperative outcomes in patients with hepatocellular carcinomas resected with exposure of the
tumor surface: clinical role of the no-margin resection. The archives of surgery. 142:596-602,
2007
64
第6章
研究結果の公表
論文
1. Miyata A, Ishizawa T, Tani K, Shimizu A, Kaneko J, Aoki T, Sakamoto Y, Sugawara
Y, Hasegawa K, Kokudo N. Reappraisal of a dye-staining technique for anatomic
hepatectomy by the concomitant use of indocyanine green fluorescence imaging. J Am
Coll Surg. Volume: 221, issue:2, pp. e27-36. Copyright©2015
DOI:[ 10.1016/j.jamcollsurg.2015.05.005]
2. Miyata A, Arita J, Shirata C, Abe S, Akamatsu N, Kaneko J, Kokudo N, Hasegawa K,
Quantitative assessment of the accuracy of real–time virtual sonography for liver
surgery. Surg innov. Volume: 27, issue:1, pp. 60-67. Copyright©[2019].
DOI:[ 10.1177/1553350619875301]
学会
1. Hepatic Staining Technique Using Fluorescence Imaging for Anatomic Resection
Miyata A, Shindoh J, Ishizawa T, Akamatsu N, Kaneko J, Aoki T, Sakamoto Y, Sugawara
Y, Hasegawa K, Kokudo N
11th World Congress of the International Hepato-Pancreato-Biliary Association: Seoul
65
2014/3/22-27
2. Real-time Virtual Sonography を用いた肝切除術
宮田明典, 青木琢, 三瀬祥弘, 有田淳一, 阿部学, 白田力, 山本訓史, 赤松延久,
金子順一, 阪本良弘, 長谷川 潔, 菅原寧彦, 國土典宏
第 76 回日本臨床外科学会総会
2014/11/22
3. Detection of invisible liver tumors using Real-time Virtual Sonography
Akinori Miyata, Yoshihiro Mise, Jyunichi Arita, Taku Aoki, Norihiro Kokudo
Annual Meeting of the Americas Hepato-Pancreato-Biliary Association: Miami
2015/3/13
4. ICG 蛍光法を用いた系統的肝切除
宮田明典、石沢武彰、山本訓史、赤松延久、有田淳一、金子順一、阪本良弘、長
谷川潔、國土典宏
第 69 回手術手技研究会
2015/5/15
5. Detection of invisible liver tumors using Real-time Virtual Sonography
66
Miyata A, Arita J, Shirata C, Abe S, Yamamoto S, Akamatu N, Kaneko J, Sakamoto Y,
Hasegawa K, Kokudo N
International Association of Surgeons, Gastroenterologists and Oncologists Continuing
Medical Education : Advanced Post-Graduate Course in Tokyo 2015: Tokyo 2015/6/13
6. インジゴカルミン染色法と ICG 蛍光法を併用した肝区域同定法の手技と成績
宮田明典、石沢武彰、山本訓史、赤松延久、有田淳一、金子順一、阪本良弘、長
谷川潔、國土典宏
第 77 回日本臨床外科学会総会
2015/11/28
7. 術中 Real-time Virtual Sonography の精度評価
宮田明典、有田淳一、小林祐太、白田力、谷圭吾、赤松延久、金子順一、阪本
良弘、長谷川潔、國土典宏
第 52 回日本肝癌研究会
2016/7/1
8. 術中 Real-time Virtual Sonography の誤差検討
宮田明典、有田淳一、小林祐太、白田力、谷圭吾、赤松延久、金子順一、阪本
良弘、長谷川潔、國土典宏
67
第 11 回肝癌治療シミュレーション研究会
2016/9/17
9. 開腹肝切除における術中 Real-time Virtual Sonography の精度検討
宮田明典、有田淳一、小林祐太、白田力、谷圭吾、赤松延久、金子順一、阪本
良弘、長谷川潔、國土典宏
第 12 回肝癌治療シミュレーション研究会
68
2017/9/30
第 7 章 謝辞
本研究においてご指導を賜った、東京大学医学部附属病院肝胆膵外科・人工
臓器移植外科教授の長谷川潔先生、国立国際医療研究センター病院理事長の國
土典宏先生、東京大学医学部附属病院肝胆膵外科・人工臓器移植外科准教授の
有田淳一先生、同講師の石沢武彰先生に感謝いたします。本研究の施行にあた
り、ご協力いただきました東京大学医学部附属病院肝胆膵外科・人工臓器移植
外科講師の金子順一先生、同講師の赤松延久先生に厚く御礼申し上げます。
69
...