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Abstract
TRANSLATIONAL APPROACH USING A NOVEL PET TRACER
RECOGNIZING AMPA RECEPTORS TO ELUCIDATE THE
MECHANISMS UNDERLYING NEUROPSYCHIATRIC DISORDERS
Tomoyuki MIYAZAKI
Department of Physiology,
Yokohama City University Graduate School of Medicine
The brain changes "plastically" in response to external stimuli such as memory and learning, and its core function
is governed by the AMPA receptors that control excitatory neurotransmission. AMPA receptors are ion channelcoupled glutamate receptors, and the robustness of a neural network is defined by the amount of AMPA receptors
expressed at synapses. In several animal studies, multiple neuropsychiatric animal models have been examined to
determine how AMPA receptors regulate neuronal functions and, further, how those functions are disrupted in the
pathophysiology of psychiatric disorders. However, how AMPA receptors behave in the living brains of patients with
neuropsychiatric disorders has remained unknown because there has been no means of verifying them. This paper
outlines the AMPA receptor that plays a central role in excitatory signaling in the brain. Furthermore, the development
of [11C]K-2, a PET drug that enables visualization of the AMPA receptors in living human brains that we were the
first in the world to develop, is presented.
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