論文の公開元へ血流増加電気刺激を併用した放射線照射療法について
概要
One of the problems in radiation and chemo therapy is the existence of a hypoxic region with a low oxygen partial pressure in the tumor. Therefore, improving hypoxia in the tumor is thought to improve therapeutic outcomes. In any case, controlling the tumor blood flow is very important for treating cancer. In contrast, the electrical stimulation has the effect to control the blood flow.
In this study, we examined the effect of radiation therapy when increasing the blood flow of the tumor using electrical stimulation. C3H/HeJ mice and SCC-VII tumor cells were used. The tumor was transplanted to outside of the thigh. The Surface electrical stimulation method was used. The stimulation site was decided lumber-sacral area（Th12-S4）considering the femoral dermatome. After applying electrical stimulation for 15 minutes, 5 Gy irradiation was performed only once. Thereafter, the tumor volume was continuously measured every day, and a tumor growth curve was prepared.
As a result, a group combined electrical stimulation and radiation had significantly slower growth than radia- tion alone（p<0.01）. Electrical stimulation might be a very effective tool for radiation therapy.
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