Acquaviva, L., Székvölgyi, L., Dichtl, B., Dichtl, B.S., Saint André, C.D.L.R., Nicolas, A., and Géli, V. (2013). The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination. Science.339, 215– 218.
Arora, C., Kee, K., Maleki, S., and Keeney, S. (2004). Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism. Mol. Cell 13, 549–559.
Baudat, F., Buard, J., Grey, C., Fledel-Alon, A., Ober, C., Przeworski, M., Coop, G., and De Massy, B. (2010). PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice. Science. 327, 836– 840.
Bergerat, A., De Massy, B., Gadelle, D., Varoutas, P.C., Nicolas, A., and Forterre, P. (1997). An atypical topoisomerase II from archaea with implications for meiotic recombination. Nature 386, 414–417.
Bhatt, A.M., Lister, C., Page, T., Fransz, P., Findlay, K., Jones, G.H., Dickinson, H.G., and Dean, C. (1999). The DIF1 gene of Arabidopsis is required for meiotic chromosome segregation and belongs to the REC8/RAD21 cohesin gene family. Plant J. 19, 463–472.
Blat, Y., Protacio, R.U., Hunter, N., and Kleckner, N. (2002). Physical and functional interactions among basic chromosome organizational features govern early steps of meiotic chiasma formation. Cell 111, 791–802.
Borde, V., and Cobb, J. (2009). Double functions for the Mre11 complex during DNA double-strand break repair and replication. Int. J. Biochem. Cell Biol. 41, 1249–1253.
Borde, V., Robine, N., Lin, W., Bonfils, S., Géli, V., and Nicolas, A. (2009). Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. EMBO J. 28, 99–111.
Borner, G. V., Barot, A., and Kleckner, N. (2008). Yeast Pch2 promotes domainal axis organization, timely recombination progression, and arrest of defective recombinosomes during meiosis. Proc. Natl. Acad. Sci. 105, 3327–3332.
Brown, S.D., Jarosinska, O.D., and Lorenz, A. (2018). Genetic interactions between the chromosome axis- associated protein Hop1 and homologous recombination determinants in Schizosaccharomyces pombe. Curr. Genet. 64, 1089–1104.
Carballo, J.A., Johnson, A.L., Sedgwick, S.G., and Cha, R.S. (2008). Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination. Cell 132, 758–770.
Carballo, J.A., Panizza, S., Serrentino, M.E., Johnson, A.L., Geymonat, M., Borde, V., Klein, F., and Cha, R.S. (2013). Budding yeast ATM/ATR control meiotic double-strand break (DSB) levels by down-regulating Rec114, an essential component of the DSB-machinery. PLoS Genet. 9. e1003545
Couteau, F., and Zetka, M. (2005). HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans. Genes Dev. 19, 2744–2756.
Couteau, F., Nabeshima, K., Villeneuve, A., and Zetka, M. (2004). A component of C. elegans meiotic chromosome axes at the interface of homolog alignment, synapsis, nuclear reorganization, and recombination. Curr. Biol. 14, 585–592.
Daniel, K., Lange, J., Hached, K., Fu, J., Anastassiadis, K., Roig, I., Cooke, H.J., Stewart, A.F., Wassmann, K., Jasin, M., et al. (2011). Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nat. Cell Biol. 13, 599–610.
Ding, D.Q., Sakurai, N., Katou, Y., Itoh, T., Shirahige, K., Haraguchi, T., and Hiraoka, Y. (2006). Meiotic cohesins modulate chromosome compaction during meiotic prophase in fission yeast. J. Cell Biol. 174, 499–508.
Ellermeier, C., and Smith, G.R. (2005). Cohesins are required for meiotic DNA breakage and recombination in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. 102, 10952–10957.
Evans, D.H., Li, Y.F., Fox, M.E., and Smith, G.R. (1997). A WD repeat protein, Rec14, essential for meiotic recombination in Schizosaccharomyces pombe. Genetics 146, 1253–1264.
Feng, J., Fu, S., Cao, X., Wu, H., Lu, J., Zeng, M., Liu, L., Yang, X., and Shen, Y. (2017). Synaptonemal complex protein 2 (SYCP2) mediates the association of the centromere with the synaptonemal complex. Protein & cell, 8(7), 538-543.
Ferdous, M., Higgins, J.D., Osman, K., Lambing, C., Roitinger, E., Mechtler, K., Armstrong, S.J., Perry, R., Pradillo, M., Cuñado, N., et al. (2012). Inter-homolog crossing-over and synapsis in arabidopsis meiosis are dependent on the chromosome axis protein AtASY3. PLoS Genet. 8. e1002507
Fukuda, T., Daniel, K., Wojtasz, L., Toth, A., and Höög, C. (2010). A novel mammalian HORMA domain- containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes. Exp. Cell Res. 316, 158–171.
Furuse, M., Nagase, Y., Tsubouchi, H., Murakami-Murofushi, K., Shibata, T., and Ohta, K. (1998). Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J. 17, 6412–6425. Garcia, V., Gray, S., Allison, R.M., Cooper, T.J., and Neale, M.J. (2015). Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation. Nature 520, 114–118.
Gregan, J., Rabitsch, P.K., Sakem, B., Csutak, O., Latypov, V., Lehmann, E., Kohli, J., and Nasmyth, K. (2005). Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast. Curr. Biol. 15, 1663–1669.
Grelon, M., Vezon, D., Gendrot, G., and Pelletier, G. (2001). AtSPO11-1 is necessary for efficient meiotic recombination in plants. EMBO J. 20, 589–600.
Grey, C., Baudat, F., and de Massy, B. (2018). PRDM9, a driver of the genetic map. PLOS Genet. 14, e1007479. Henderson, K.A., Kee, K., Maleki, S., Santini, P.A., and Keeney, S. (2006). Cyclin-Dependent Kinase Directly Regulates Initiation of Meiotic Recombination. Cell 125, 1321–1332.
Hollingsworth, N.M., and Byers, B. (1989). HOP1: a yeast meiotic pairing gene. Genetics 121, 445–462. Hollingsworth, N.M., Goetsch, L., and Byers, B. (1990). The HOP1 gene encodes a meiosis-specific component of yeast chromosomes. Cell 61, 73–84.
Ishiguro, K.I., Kim, J., Fujiyama-Nakamura, S., Kato, S., and Watanabe, Y. (2011). A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing. EMBO Rep. 12, 267–275.
Ito, M., Kugou, K., Fawcett, J.A., Mura, S., Ikeda, S., Innan, H., and Ohta, K. (2014). Meiotic recombination cold spots in chromosomal cohesion sites. Genes to Cells 19, 359–373.
Jolivet, S., Vezon, D., Froger, N., and Mercier, R. (2006). Non conservation of the meiotic function of the Ski8/Rec103 homolog in Arabidopsis. Genes to Cells 11, 615–622.
Joshi, N., Barot, A., Jamison, C., and Börner, G.V. (2009). Pch2 links chromosome axis remodeling at future crossover sites and crossover distribution during yeast meiosis. PLoS Genet. 5, e1000557.
Kee, K., Protacio, R.U., Arora, C., and Keeney, S. (2004). Spatial organization and dynamics of the association of Rec102 and Rec104 with meiotic chromosomes. EMBO J. 23, 1815–1824.
Keeney, S., Giroux, C.N., and Kleckner, N. (1997). Meiosis-Specific DNA Double-Strand Breaks Are Catalyzed by Spo11, a Member of a Widely Conserved Protein Family. Cell 88, 375–384.
Kim, K.P., Weiner, B.M., Zhang, L., Jordan, A., Dekker, J., and Kleckner, N. (2010). Sister cohesion and structural axis components mediate homolog bias of meiotic recombination. Cell 143, 924–937.
Kim, Y., Rosenberg, S.C., Kugel, C.L., Kostow, N., Rog, O., Davydov, V., Su, T.Y., Dernburg, A.F., and Corbett,
K.D. (2014). The chromosome axis controls meiotic events through a hierarchical assembly of HORMAdomain proteins. Dev. Cell 31, 487–502.
Kitajima, T.S., Yokobayashi, S., Yamamoto, M., and Watanabe, Y. (2003). Distinct cohesin complexes organize meiotic chromosome domains. Science. 300, 1152–1155.
Kleckner, N. (2006). Chiasma formation: Chromatin/axis interplay and the role(s) of the synaptonemal complex. Chromosoma 115, 175–194.
Klein, F., Mahr, P., Galova, M., Buonomo, S.B.C., Michaelis, C., Nairz, K., and Nasmyth, K. (1999). A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Cell 98, 91–103.
Kugou, K., Fukuda, T., Yamada, S., Ito, M., Sasanuma, H., Mori, S., Katou, Y., Itoh, T., Matsumoto, K., Shibata, T., et al. (2009). Rec8 guides canonical Spo11 distribution along yeast meiotic chromosomes. Mol. Biol. Cell 20, 3064–3076.
Kumar, R., Bourbon, H.M., and De Massy, B. (2010). Functional conservation of Mei4 for meiotic DNA double- strand break formation from yeasts to mice. Genes Dev. 24, 1266–1280.
Lam, I., and Keeney, S. (2015). Mechanism and regulation of meiotic recombination initiation. Cold Spring Harb. Perspect. Biol. 7, a016634.
Latypov, V., Rothenberg, M., Lorenz, A., Octobre, G., Csutak, O., Lehmann, E., Loidl, J., and Kohli, J. (2010). Roles of Hop1 and Mek1 in Meiotic Chromosome Pairing and Recombination Partner Choice in Schizosaccharomyces pombe. Mol. Cell. Biol. 30, 1570–1581.
Lee, J., and Hirano, T. (2011). RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. J. Cell Biol. 192, 263–276.
Libby, B.J., Reinholdt, L.G., and Schimenti, J.C. (2003). Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice. Proc. Natl. Acad. Sci. 100, 15706–15711.
Lin, Y., Larson, K.L., Dorer, R., and Smith, G.R. (1992). Meiotically induced rec7 and rec8 genes of Schizosaccharomyces pombe. Genetics 132, 75–85.
Lorenz, A. (2004). S. pombe meiotic linear elements contain proteins related to synaptonemal complex components. J. Cell Sci. 117, 3343–3351.
Ludin, K., Mata, J., Watt, S., Lehmann, E., Bähler, J., and Kohli, J. (2008). Sites of strong Rec12/Spo11 binding in the fission yeast genome are associated with meiotic recombination and with centromeres. Chromosoma 117, 431–444.
Mao-Draayer, Y., Galbraith, A.M., Pittman, D.L., Cool, M., and Malone, R.E. (1996). Analysis of meiotic recombination pathways in the yeast Saccharomyces cerevisiae. Genetics 144, 71–86.
Medhi, D., Goldman, A.S.H., and Lichten, M. (2016). Local chromosome context is a major determinant of crossover pathway biochemistry during budding yeast meiosis. Elife 5, 1–20.
Miyoshi, T., Ito, M., Kugou, K., Yamada, S., Furuichi, M., Oda, A., Yamada, T., Hirota, K., Masai, H., and Ohta, K. (2012). Acentral coupler for recombination initiation linking chromosome architecture to S phase checkpoint. Mol. Cell 47, 722–733.
Molnar, M. (2003). Linear element formation and their role in meiotic sister chromatid cohesion and chromosome pairing. J. Cell Sci. 116, 1719–1731.
Molnar, M., Bahler, J., Sipiczki, M., and Kohli, J. (1995). The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing and sister-chromatid cohesion during meiosis. Genetics 141, 61–73.
Muller, H., Scolari, V.F., Agier, N., Piazza, A., Thierry, A., Mercy, G., Descorps‐Declere, S., Lazar‐Stefanita, L., Espeli, O., Llorente, B., et al. (2018). Characterizing meiotic chromosomes’ structure and pairing using a designer sequence optimized for Hi‐C. Mol. Syst. Biol. 14, e8293.
Murakami, H., and Keeney, S. (2014). Temporospatial coordination of meiotic dna replication and recombination via DDK recruitment to replisomes. Cell 158, 861–873. De Muyt, A., Vezon, D., Gendrot, G., Gallois, J.L., Stevens, R., and Grelon, M. (2007). AtPRD1 is required for meiotic double strand break formation in Arabidopsis thaliana. EMBO J. 26, 4126–4137.
Neale, M.J., Pan, J., and Keeney, S. (2005). Endonucleolytic processing of covalent protein-linked DNAdouble- strand breaks. Nature 436, 1053–1057.
Niu, H., Wan, L., Baumgartner, B., Schaefer, D., Loidl, J., and Hollingsworth, N.M. (2005). Partner choice during meiosis is regulated by Hop1-promoted dimerization of Mek1. Mol. Biol. Cell 16, 5804–5818.
Offenberg, H.H., Schalk, J.A.C., Meuwissen, R.L.J., Van Aalderen, M., Kester, H.A., Dietrich, A.J.J., and Heyting, C. (1998). SCP2: A major protein component of the axial elements of synaptonemal complexes of the rat. Nucleic Acids Res. 26, 2572–2579.
Ohta, K., Shibata, T., and Nicolas, A. (1994). Changes in chromatin structure at recombination initiation sites during yeast meiosis. Embo J 13, 5754–5763.
Pan, J., Sasaki, M., Kniewel, R., Murakami, H., Blitzblau, H.G., Tischfield, S.E., Zhu, X., Neale, M.J., Jasin, M., Socci, N.D., et al. (2011). A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation. Cell 144, 719–731.
Panizza, S., Mendoza, M.A., Berlinger, M., Huang, L., Nicolas, A., Shirahige, K., and Klein, F. (2011). Spo11- accessory proteins link double-strand break sites to the chromosome axis in early meiotic recombination. Cell 146, 372–383.
Parisi, S., McKay, M.J., Molnar, M., Thompson, M.A., van der Spek, P.J., van Drunen-Schoenmaker, E., Kanaar, R., Lehmann, E., Hoeijmakers, J.H.J., and Kohli, J. (1999). Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. Mol. Cell. Biol. 19, 3515–3528.
Robert, T., Nore, A., Brun, C., Maffre, C., Crimi, B., Guichard, V., Bourbon, H.M., and De Massy, B. (2016). The Topo VIB-Like protein family is required for meiotic DNAdouble-strand break formation. Science.351, 943–949. Rockmill, B., and Roeder, G.S. (1988). RED1: a yeast gene required for the segregation of chromosomes during the reductional division of meiosis. Proc. Natl. Acad. Sci. U. S. A. 85, 6057–6061.
Rockmill, B., and Roeder, G.S. (1991). A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination. Genes Dev. 5, 2392–2404.
Rosenberg, S.C., and Corbett, K.D. (2015). The multifaceted roles of the HORMA domain in cellular signalling. J. Cell Biol. 211, 745–755.
Rothenberg, M., Kohli, J., and Ludin, K. (2009). Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast. PLoS Genet. 5, e1000722. Sanchez-Moran, E., Santos, J.L., Jones, G.H., and Franklin, F.C.H. (2007). ASY1 mediates AtDMC1- dependent interhomolog recombination during meiosis in Arabidopsis. Genes Dev. 21, 2220–2233.
Sasanuma, H., Hirota, K., Fukuda, T., Kakusho, N., Kugou, K., Kawasaki, Y., Shibata, T., Masai, H., and Ohta, K. (2008). Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination. Genes Dev. 22, 398–410.
Stanzione, M., Baumann, M., Papanikos, F., Dereli, I., Lange, J., Ramlal, A., Tränkner, D., Shibuya, H., De Massy, B., Watanabe, Y., et al. (2016). Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice. Nat. Cell Biol. 18, 1208–1220.
Sym, M., Engebrecht, J.A., and Roeder, G.S. (1993). ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis. Cell 72, 365–378.
Tessé, S., Bourbon, H.M., Debuchy, R., Budin, K., Dubois, E., Liangran, Z., Antoine, R., Piolot, T., Kleckner, N., Zickler, D., et al. (2017). Asy2/Mer2: An evolutionarily conserved mediator of meiotic recombination, pairing, and global chromosome compaction. Genes Dev. 31, 1880–1893.
Usui, T., Ohta, T., Oshiumi, H., Tomizawa, J.I., Ogawa, H., and Ogawa, T. (1998). Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95, 705–716.
Vrielynck, N., Chambon, A., Vezon, D., Pereira, L., Chelysheva, L., De Muyt, A., Mézard, C., Mayer, C., and Grelon, M. (2016). A DNA topoisomerase VI-like complex initiates meiotic recombination. Science.351, 939– 943.
Watanabe, Y., and Nurse, P. (1999). Cohesin Rec8 is required for reductional chromosome segregation at meiosis. Nature 400, 461–464.
West,A.M.V., Komives,E.A. and Corbett,K.D. (2018) Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. Nucleic Acids Res., 46, 279–292.
West, A.M. V, Rosenberg, S.C., Ur, S.N., Lehmer, M.K., Ye, Q., Hagemann, G., Caballero, I., Usón, I., MacQueen, A.J., Herzog, F., et al. (2019). A conserved filamentous assembly underlies the structure of the meiotic chromosome axis. Elife 8, e40372.
Wojtasz, L., Daniel, K., Roig, I., Bolcun-Filas, E., Xu, H., Boonsanay, V., Eckmann, C.R., Cooke, H.J., Jasin, M., Keeney, S., et al. (2009). Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase. PLoS Genet. 5, e1000702.
Woltering,D., Baumgartner,B., Bagchi,S., Larkin,B., Loidl,J., Santos,T.D.L. and Hollingsworth,N.M. (2000) Recombination Checkpoint Functions Require Physical Interaction between the Chromosomal Proteins Red1p and Hop1p. Mol. Cell. Biol., 20, 6646–6658.
Wu, T.C., and Lichten, M. (1994). Meiosis-induced double-strand break sites determined by yeast chromatin structure. Science.263, 515–518.
Xu, H., Beasley, M.D., Warren, W.D., van der Horst, G.T.J., and McKay, M.J. (2005). Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. Dev. Cell 8, 949–961.
Xu, L., Weiner, B.M., and Kleckner, N. (1997). Meiotic cells monitor the status of the interhomolog recombination complex. Genes Dev. 11, 106–118.
Yamada, S., Ohta, K., and Yamada, T. (2013). Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Nucleic Acids Res. 41, 3504–3517.
Yamada, T., Mizuno, K.I., Hirota, K., Kon, N., Wahls, W.P., Hartsuiker, E., Murofushi, H., Shibata, T., and Ohta, K. (2004). Roles of histone acetylation and chromatin remodelling factor in a meiotic recombination hotspot. EMBO J. 23, 1792–1803.
Zickler, D., and Kleckner, N. (2015). Recombination, pairing, and synapsis of homologs during meiosis. Cold Spring Harb. Perspect. Biol. 7, 1–28
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