1.
Lingeman, C.H., F.M. Garner, and D.O. Taylor, Spontaneous gastric
adenocarcinomas of dogs: a review. J Natl Cancer Inst, 1971. 47: p. 13753.
2.
Sullivan, M., et al., A study of 31 cases of gastric carcinoma in dogs. Vet
Rec, 1987. 120: p. 79-83.
3.
Seim-Wikse, T., et al., Breed predisposition to canine gastric carcinoma -a study based on the Norwegian canine cancer register. Acta Vet Scand,
2013. 55: p. 25.
4.
Sautter, J.H. and G.F. Hanlon, Gastric neoplasms in the dog: a report of
20 cases. J Am Vet Med Assoc, 1975. 166: p. 691-6.
5.
Frgelecová,
L., et
al., Canine
gastrointestinal
tract
tumours:
restrospective study of 74 cases. Acta Vet. Brno, 2013. 82: p. 387-392.
6.
Patnaik,
A.K.,
A.I.
Hurvitz, and G.F.
Johnson, Canine
gastric
adenocarcinoma. Vet Pathol, 1978. 15: p. 600-7.
7.
Patnaik, A.K., A.I. Hurvitz, and G.F. Johnson, Canine gastrointestinal
neoplasms. Vet Pathol, 1977. 14: p. 547-55.
8.
Holt,
P.E.
and
V.M.
Lucke,
Rectal
neoplasia
in
the
dog:
clinicopathological review of 31 cases. Vet Rec, 1985. 116: p. 400-5.
9.
国立がん研究センターがん情報サービス .
Available from: https://ganjoho.jp/reg_stat/statistics/dl/index.html.
10.
ラットの背景病変. マウスの背景病変. 新毒性病理組織学. 西村書
店. p705-735.
11.
Chandra, S.A., M.W. Nolan, and D.E. Malarkey, Chemical carcinogenesis
85
of the gastrointestinal tract in rodents: an overview with emphasis on NTP
carcinogenesis bioassays. Toxicol Pathol, 2010. 38: p. 188-97.
12.
Nalbantoglu, I., V. Blanc, and N.O. Davidson, Characterization of
Colorectal Cancer Development in Apc (min/+) Mice. Methods Mol Biol,
2016. 1422: p. 309-27.
13.
Johnson, R.L. and J.C. Fleet, Animal models of colorectal cancer. Cancer
Metastasis Rev, 2013. 32: p. 39-61.
14.
Youmans, L., et al., Frequent alteration of the tumor suppressor gene APC
in sporadic canine colorectal tumors. PLoS One, 2012. 7: p. e50813.
15.
Morson, B.C., Precancerous and early malignant lesions of the large
intestine. Br J Surg, 1968. 55: p. 725-31.
16.
Morson, B., President's address. The polyp-cancer sequence in the large
bowel. Proc R Soc Med, 1974. 67: p. 451-7.
17.
Muto, T., H.J. Bussey, and B.C. Morson, The evolution of cancer of the
colon and rectum. Cancer, 1975. 36: p. 2251-70.
18.
Vogelstein, B., et al., Genetic alterations during colorectal -tumor
development. N Engl J Med, 1988. 319: p. 525-32.
19.
Fearon, E.R. and B. Vogelstein, A genetic model for colorectal
tumorigenesis. Cell, 1990. 61: p. 759-67.
20.
Turner, J.R., The Gastrointestinal Tract in Robbins and Cotran Pathologic
Basis of Disease. 2014, Saunders. p. 749-819.
21.
Kuramoto, S. and T. Oohara, Minute cancers arising de novo in the human
large intestine. Cancer, 1988. 61: p. 829-34.
22.
SPRATT, J.S., L.V. ACKERMAN, and C.A. MOYER, Relationship of
86
polyps of the colon to colonic cancer. Ann Surg, 1958. 148: p. 682-96;
discussion 696-8.
23.
CASTLEMAN, B. and H.I. KRICKSTEIN, Do adenomatous polyps of the
colon become malignant? N Engl J Med, 1962. 267: p. 469-75.
24.
Groden, J., et al., Identification and characterization of the familial
adenomatous polyposis coli gene. Cell, 1991. 66: p. 589-600.
25.
Nakamura, Y., et al., Mutations of the adenomatous polyposis coli gene in
familial polyposis coli patients and sporadic colorectal tumors. Princess
Takamatsu Symp, 1991. 22: p. 285-92.
26.
Kinzler, K.W., et al., Identification of FAP locus genes from chromosome
5q21. Science, 1991. 253: p. 661-5.
27.
Kinzler, K.W. and B. Vogelstein, Lessons from hereditary colorectal
cancer. Cell, 1996. 87: p. 159-70.
28.
Kolligs, F.T., G. Bommer, and B. Göke, Wnt/beta-catenin/tcf signaling: a
critical pathway in gastrointestinal tumorigenesis. Digestion, 2002. 66: p.
131-44.
29.
Kumar, V., Neoplasia in Robbins and Cortan Pathologic Basis of Dis ease.
2014. p. 265-340.
30.
de Lau, W., et al., The R-spondin/Lgr5/Rnf43 module: regulator of Wnt
signal strength. Genes Dev, 2014. 28: p. 305-16.
31.
Steinhart, Z. and S. Angers, Wnt signaling in development and tissue
homeostasis. Development, 2018. 145.
32.
Behrens, J., et al., Functional interaction of beta -catenin with the
transcription factor LEF-1. Nature, 1996. 382: p. 638-42.
87
33.
Clevers, H., Wnt/beta-catenin signaling in development and disease. Cell,
2006. 127: p. 469-80.
34.
Molenaar, M., et al., XTcf-3 transcription factor mediates beta-catenininduced axis formation in Xenopus embryos. Cell, 1996. 86: p. 391-9.
35.
van de Wetering, M., et al., Armadillo coactivates transcription driven by
the product of the Drosophila segment polarity gene dTCF. Cell, 1997. 88:
p. 789-99.
36.
van de Wetering, M., et al., The beta-catenin/TCF-4 complex imposes a
crypt progenitor phenotype on colorectal cancer cells. Cell, 2002. 111: p.
241-50.
37.
Head, K.W., et al., Histological classification of tumors of the a limentary
system of domestic animals. World Health Organization international
histological classification of tumors of domestic animals ; 2nd ser., v. 10.
2003: Washington, DC : Published by the Armed Forces Institute of
Pathology in cooperation with the American Registry of Pathology and the
World
Health
Organization
Collaborating
Center
for
Worldwide
Reference on Comparative Oncology, 2003.
38.
ACKERMAN, L.V. and J.S. SPRATT, Do adenomatous polyps become
cancer? Gastroenterology, 1963. 44: p. 905-8.
39.
ACKERMAN,
L.V.,
MALIGNANT
POTENTIAL
OF
POLYPOID
LESIONS OF THE LARGE INTESTINE. Trans Stud Coll Physicians Phila,
1964. 32: p. 5-14.
40.
Shimoda, T., et al., Early colorectal carcinoma with special reference to
its development de novo. Cancer, 1989. 64: p. 1138-46.
88
41.
Kudo, S., H. Kashida, and T. Tamura, Early colorectal cancer: flat or
depressed type. J Gastroenterol Hepatol, 2000. 15 Suppl: p. D66-70.
42.
Iishi, H., et al., Early depressed adenocarcinomas of the large intestine.
Cancer, 1992. 69: p. 2406-10.
43.
Frgelecová,
L., et
al., Canine
gastrointestinal
tract
tumours:
restrospective study of 74 cases. Acta Veterinaria Brno, 2013. 82: p. 387392.
44.
Fonda, D., M. Gualtieri, and E. Scanziani, Gastric carcinoma in the dog:
A clinicopathological study of 11 cases. J Small Anim Pract, 1989. 30: p.
353-360.
45.
Al-Sukhni, W., M. Aronson, and S. Gallinger, Hereditary colorectal cancer
syndromes: familial adenomatous polyposis and lynch syndrome. Surg
Clin North Am, 2008. 88: p. 819-44, vii.
46.
Half, E., D. Bercovich, and P. Rozen, Familial adenomatous polyposis.
Orphanet J Rare Dis, 2009. 4: p. 22.
47.
Hernegger, G.S., H.G. Moore, and J.G. Guillem, Attenuated familial
adenomatous polyposis: an evolving and poorly understood entity. Dis
Colon Rectum, 2002. 45: p. 127-34; discussion 134-6.
48.
Soravia, C., et al., Genotype-phenotype correlations in attenuated
adenomatous polyposis coli. Am J Hum Genet, 1998. 62: p. 1290-301.
49.
Yoshizaki, K., et al., Familial Adenomatous Polyposis in Dogs: Hereditary
Gastrointestinal Polyposis in Jack Russell Terriers with Germline APC
Mutations. Carcinogenesis, 2020.
50.
Ohmi, A., et al., A retrospective study of inflammatory colorectal polyps
89
in miniature dachshunds. J Vet Med Sci, 2012. 74: p. 59-64.
51.
Uchida, E., et al., Pathologic Features of Colorectal Inflammatory Polyps
in Miniature Dachshunds. Vet Pathol, 2016. 53: p. 833-9.
52.
Kamano, T., et al., Experimental colonic cancer in a dog. Jpn J Surg, 1981.
11: p. 214-8.
53.
Patnaik, A.K. and P.H. Lieberman, Gastric squamous cell carcinoma in a
dog. Vet Pathol, 1980. 17: p. 250-3.
54.
Ikegami, M., A pathological study on colorectal cancer. From de novo
carcinoma to advanced carcinoma. Acta Pathol Jpn, 1987. 37: p. 21-37.
55.
Kuramoto, S. and T. Oohara, Flat early cancers of the large intestine.
Cancer, 1989. 64(4): p. 950-5.
56.
Matsui, T., et al., Natural history of superficial depressed colorectal
cancer: retrospective radiographic and histologic analysis. Radiology,
1996. 201: p. 226-32.
57.
Kurisu, Y., et al., Histologic and immunohistochemical analysis of early
submucosal invasive carcinoma of the colon and rectum. Pathol Int, 1999.
49: p. 608-16.
58.
Ohta, H., et al., Expression of CD4+ T cell cytokine genes in the colorectal
mucosa of inflammatory colorectal polyps in miniature dachshunds. Vet
Immunol Immunopathol, 2013. 155: p. 259-63.
59.
Tamura, Y., et al., Markedly increased expression of interleukin -8 in the
colorectal mucosa of inflammatory colorectal polyps in miniature
dachshunds. Vet Immunol Immunopathol, 2013. 156: p. 32-42.
60.
Igarashi, H., et al., Functional analysis of pattern recognition receptors in
90
miniature dachshunds with inflammatory colorectal polyps. J Vet Med Sci,
2015. 77: p. 439-47.
61.
Igarashi, H., et al., Expression profiling of pattern re cognition receptors
and selected cytokines in miniature dachshunds with inflammatory
colorectal polyps. Vet Immunol Immunopathol, 2014. 159: p. 1-10.
62.
Tsukamoto, A., et al., A case of canine multiple inflammatory colorectal
polyps treated by endoscopic polypectomy and argon plasma coagulation.
J Vet Med Sci, 2012. 74: p. 503-6.
63.
Igarashi, H., et al., Polypoid adenomas secondary to inflammatory
colorectal polyps in 2 miniature dachshunds. J Vet Med Sci, 2013. 75: p.
535-8.
64.
Peifer, M., et al., The vertebrate adhesive junction proteins beta-catenin
and plakoglobin and the Drosophila segment polarity gene armadillo form
a multigene family with similar properties. J Cell Biol, 1992. 118: p. 68191.
65.
Nishisho, I., et al., Mutations of chromosome 5q21 genes in FAP and
colorectal cancer patients. Science, 1991. 253: p. 665-9.
66.
Rubinfeld, B., et al., Binding of GSK3beta to the APC -beta-catenin
complex and regulation of complex assembly. Science, 1996. 272: p. 10236.
67.
Head KW, E.R., Dubielzig RR, Tumors of the Alimentary Tract. 4 ed.
Tumors in Domestic Animals. 2002: Iowa State Press.
68.
Uzal, F.A., B.L. Plattner, and J.M. Hostetter, Neoplastc and proliferative
lesions of the stomach and intestine. 6 ed. Jubb, Kennedy & Palmer's
91
Pathology of Domestic Animals, ed. M. Grant. Vol. 2. 2015: Saunders
Ltd.
69.
Almagro, U.A., K. Pintar, and R.B. Zellmer, Squamous metaplasia in
colorectal polyps. Cancer, 1984. 53: p. 2679-82.
70.
Bansal, M., et al., Are metaplasias in colorectal adenomas truly
metaplasias? Am J Pathol, 1984. 115: p. 253-65.
71.
Chen, K.T., Colonic adenomatous polyp with focal squamous metaplasia.
Hum Pathol, 1981. 12: p. 848-9.
72.
Hayashi, I., et al., Tubular adenoma with focal squamous metaplasia of the
ascending colon. Acta Pathol Jpn, 1985. 35(2): p. 507-15.
73.
Kontozoglou, T., Squamous metaplasia in colonic adenomata: report of
two cases. J Surg Oncol, 1985. 29: p. 31-4.
74.
Houghton, O., L.E. Connolly, and W.G. McCluggage, Morules in
endometrioid proliferations of the uterus and ovary consistently express
the intestinal transcription factor CDX2. Histopathology, 2008. 53: p. 15665.
75.
Wani, Y., et al., Aberrant Cdx2 expression in endometrial lesions with
squamous differentiation: important role of Cdx2 in squamous morula
formation. Hum Pathol, 2008. 39: p. 1072-9.
76.
Petris, G.D. and L. Chen, Morules in fundic gland polyposis: a case report.
Int J Clin Exp Pathol, 2014. 7: p. 1241-5.
77.
Mochizuki, K., et al., Squamous morula formation in colorectal adenoma:
Immunohistochemical and molecular analyses. Pathol Res Pract, 2015.
211: p. 797-800.
92
78.
Pantanowitz, L., Colonic adenoma with squamous metaplasia. Int J Surg
Pathol, 2009. 17: p. 340-2.
79.
Buchley, C.H., Normal endometrium and non-proliferative conditions of
the endometrium. 5th ed, ed. H. Fox. 2003, Haines & Taylor Obstetrical
and Gynaecological Pathology: Churchill Livingstone.
80.
McEntee, M.F. and K.A. Brenneman, Dysregulation of beta-catenin is
common in canine sporadic colorectal tumors. Vet Pathol, 1999. 36: p.
228-36.
81.
Restucci, B., et al., Expression of E-cadherin, beta-catenin and APC
protein in canine colorectal tumours. Anticancer Res, 2009. 29: p. 291925.
82.
Powell, S.M., et al., APC mutations occur early during colorectal
tumorigenesis. Nature, 1992. 359: p. 235-7.
83.
Tsao, J. and D. Shibata, Further evidence that one of the earliest alterations
in colorectal carcinogenesis involves APC. Am J Pathol, 1994. 145: p.
531-4.
84.
Soetikno, R.M., et al., Prevalence of nonpolypoid (flat and depressed)
colorectal neoplasms in asymptomatic and symptomatic adults. JAMA,
2008. 299: p. 1027-35.
85.
Crawford, B.E. and F.W. Stromeyer, Small nonpolypoid carcinomas of the
large intestine. Cancer, 1983. 51: p. 1760-3.
86.
Minamoto, T., et al., Superficial-type adenomas and adenocarcinomas of
the
colon
and
rectum:
comparative
Gastroenterology, 1994. 106: p. 1436-43.
93
morphological
study.
87.
Hasegawa, H., et al., p53 gene mutations in early colorectal carcinoma. De
novo vs. adenoma-carcinoma sequence. Int J Cancer, 1995. 64: p. 47-51.
88.
Mueller, J.D., B. Bethke, and M. Stolte, Colorectal de novo carcinoma: a
review of its diagnosis, histopathology, molecular biology, and clinical
relevance. Virchows Arch, 2002. 440: p. 453-60.
89.
Yamagishi, H., et al., Molecular pathogenesis of sporadic colorectal
cancers. Chin J Cancer, 2016. 35: p. 4.
90.
Minamoto, T., et al., Infrequent K-ras activation in superficial-type (flat)
colorectal adenomas and adenocarcinomas. Cancer Res, 1994. 54: p. 28414.
91.
Umetani, N., et al., Involvement of APC and K-ras mutation in nonpolypoid colorectal tumorigenesis. Br J Cancer, 2000. 82: p. 9-15.
92.
Yagi, O.K., et al., Analyses of the APC and TGF-beta type II receptor
genes, and microsatellite instability in mucosal colorectal carcinomas. Jpn
J Cancer Res, 1997. 88: p. 718-24.
93.
Muta, H., et al., E-cadherin gene mutations in signet ring cell carcinoma
of the stomach. Jpn J Cancer Res, 1996. 87: p. 843-8.
94.
Berx, G. and F. van Roy, Involvement of members of the cadherin
superfamily in cancer. Cold Spring Harb Perspect Biol, 2009. 1: p.
a003129.
95.
Kikuchi-Yanoshita, R., et al., Genetic changes of both p53 alleles
associated with the conversion from colorectal adenoma to early
carcinoma
in
familial
adenomatous
polyposis
and
non -familial
adenomatous polyposis patients. Cancer Res, 1992. 52: p. 3965-71.
94
96.
Ohue, M., et al., A frequent alteration of p53 gene in carcinoma in
adenoma of colon. Cancer Res, 1994. 54: p. 4798-804.
97.
Ichii, S., et al., Inactivation of both APC alleles in an early stage of colon
adenomas in a patient with familial adenomatous polyposis (FAP). Hum
Mol Genet, 1992. 1: p. 387-90.
98.
Munemitsu, S., et al., Regulation of intracellular beta-catenin levels by the
adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl
Acad Sci U S A, 1995. 92: p. 3046-50.
99.
Hinoi, T., et al., Complex formation of adenomatous polyposis coli gene
product and axin facilitates glycogen synthase kinase -3 beta-dependent
phosphorylation of beta-catenin and down-regulates beta-catenin. J Biol
Chem, 2000. 275(44): p. 34399-406.
100.
Morin, P.J., et al., Activation of beta-catenin-Tcf signaling in colon cancer
by mutations in beta-catenin or APC. Science, 1997. 275: p. 1787-90.
101.
Tomita, H., et al., Development of gastric tumors in Apc(Min/+) mic e by
the activation of the beta-catenin/Tcf signaling pathway. Cancer Res, 2007.
67: p. 4079-87.
102.
Chiurillo, M.A., Role of the Wnt/β-catenin pathway in gastric cancer: An
in-depth literature review. World J Exp Med, 2015. 5: p. 84-102.
103.
Hugen, S., et al., Gastric carcinoma in canines and humans, a review. Vet
Comp Oncol, 2016.
104.
Tian, X., et al., E-cadherin/β-catenin complex and the epithelial barrier. J
Biomed Biotechnol, 2011. 2011: p. 567305.
105.
Kadowaki, T., et al., E-cadherin and alpha-catenin expression in human
95
esophageal cancer. Cancer Res, 1994. 54: p. 291-6.
106.
Ochiai, A., et al., Frequent loss of alpha catenin expression in scirrhous
carcinomas with scattered cell growth. Jpn J Cancer Res, 1994. 85: p. 26673.
107.
Xiangming, C., et al., The expression of cadherin-catenin complex in
association with the clinicopathologic features of early gastric cancer.
Surg Today, 1998. 28: p. 587-94.
108.
Pećina-Slaus, N., Tumor suppressor gene E-cadherin and its role in normal
and malignant cells. Cancer Cell Int, 2003. 3: p. 17.
109.
Frixen, U.H., et al., E-cadherin-mediated cell-cell adhesion prevents
invasiveness of human carcinoma cells. J Cell Biol, 1991. 113: p. 173-85.
110.
Vleminckx, K., et al., Genetic manipulation of E-cadherin expression by
epithelial tumor cells reveals an invasion suppressor role. Cell, 1991. 66:
p. 107-19.
111.
Mayer, B., et al., E-cadherin expression in primary and metastatic gastric
cancer: down-regulation correlates with cellular dedifferentiation and
glandular disintegration. Cancer Res, 1993. 53: p. 1690-5.
112.
Shimoyama, Y. and S. Hirohashi, Expression of E- and P-cadherin in
gastric carcinomas. Cancer Res, 1991. 51: p. 2185-92.
113.
Kim, H.C., H.J. Kim, and J.C. Kim, Reduced E-cadherin expression as a
cause of distinctive signet-ring cell variant in colorectal carcinoma. J
Korean Med Sci, 2002. 17: p. 23-8.
114.
Nigam, A.K., et al., Loss of cell-cell and cell-matrix adhesion molecules
in colorectal cancer. Br J Cancer, 1993. 68: p. 507-14.
96
115.
Shiozaki, H., et al., Expression of immunoreactive E-cadherin adhesion
molecules in human cancers. Am J Pathol, 1991. 139: p. 17-23.
116.
Aresu, L., et al., E-cadherin and β-catenin expression in canine colorectal
adenocarcinoma. Res Vet Sci, 2010. 89: p. 409-14.
117.
Kroepil, F., et al., Down-regulation of CDH1 is associated with expression
of SNAI1 in colorectal adenomas. PLoS One, 2012. 7: p. e46665.
118.
Ando, K., et al., Discrimination of p53 immunohistochemistry-positive
tumors by its staining pattern in gastric cancer. Cancer Med, 2015. 4: p.
75-83.
119.
Finlay, C.A., et al., Activating mutations for transformation by p53
produce a gene product that forms an hsc70-p53 complex with an altered
half-life. Mol Cell Biol, 1988. 8: p. 531-9.
120.
Gronostajski, R.M., A.L. Goldberg, and A.B. Pardee, Energy requirement
for degradation of tumor-associated protein p53. Mol Cell Biol, 1984. 4:
p. 442-8.
121. Kaklamanis, L., et al., p53 expression in colorectal adenomas. Am J Pathol,
1993. 142: p. 87-93.
122.
Fenoglio-Preiser, C.M., et al., TP53 and gastric carcinoma: a review. Hum
Mutat, 2003. 21: p. 258-70.
123.
Fernandez-Pol, S., et al., Immunohistochemistry for p53 is a useful tool to
identify cases of acute myeloid leukemia with myelodysplasia -related
changes that are TP53 mutated, have complex karyotype, and have poor
prognosis. Mod Pathol, 2017. 30: p. 382-392.
124.
Kmet, L.M., L.S. Cook, and A.M. Magliocco, A review of p53 expression
97
and mutation in human benign, low malignant potential, and invasive
epithelial ovarian tumors. Cancer, 2003. 97: p. 389-404.
125.
Rodrigues, N.R., et al., p53 mutations in colorectal cancer. Proc Natl Acad
Sci U S A, 1990. 87: p. 7555-9.
126.
Carrasco, V., et al., Canine gastric carcinoma: immunohistochemical
expression of cell cycle proteins (p53, p21, and p16) and heat shock
proteins (Hsp27 and Hsp70). Vet Pathol, 2011. 48: p. 322-9.
127.
Chambers, J.K., et al., Adenocarcinoma of Barrett's esophagus in a dog. J
Toxicol Pathol, 2017. 30: p. 239-243.
128.
Gamblin, R.M., J.E. Sagartz, and C.G. Couto, Overexpression of p53
tumor suppressor protein in spontaneously arising neoplasms of dogs. Am
J Vet Res, 1997. 58: p. 857-63.
129.
Haga, S., et al., Overexpression of the p53 gene product in canine
mammary tumors. Oncol Rep, 2001. 8: p. 1215-9.
130.
Wolf, J.C., et al., Immunohistochemical detection of p53 tumor suppressor
gene protein in canine epithelial colorectal tumors. Vet Pathol, 1997. 34:
p. 394-404.
131.
Munday, J.S., C.V. Löhr, and M. Kiupel, Tumors of the Alimentary Tract
in "Tumors in Domestic
Animals". Fifth Edition ed. 2017: Wiley-
Blackwell.
132.
Triantafillidis, J.K., G. Nasioulas, and P.A. Kosmidis, Colorectal cancer
and inflammatory bowel disease: epidemiology, risk factors, mechanisms
of carcinogenesis and prevention strategies. Anticancer Res, 2009. 29: p.
2727-37.
98
133.
Kameyama, H., et al., Genomic characterization of colitis -associated
colorectal cancer. World J Surg Oncol, 2018. 16: p. 121.
134.
Weber, C.R., et al., Claudin-1 and claudin-2 expression is elevated in
inflammatory bowel disease and may contribute to early neoplastic
transformation. Lab Invest, 2008. 88: p. 1110-20.
135.
Grivennikov, S.I., Inflammation and colorectal cancer: colitis -associated
neoplasia. Semin Immunopathol, 2013. 35: p. 229-44.
99
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