リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

リケラボ 全国の大学リポジトリにある学位論文・教授論文を一括検索するならリケラボ論文検索大学・研究所にある論文を検索できる

大学・研究所にある論文を検索できる 「Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids」の論文概要。リケラボ論文検索は、全国の大学リポジトリにある学位論文・教授論文を一括検索できる論文検索サービスです。

コピーが完了しました

URLをコピーしました

論文の公開元へ論文の公開元へ
書き出し

Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids

Kitahara, Takahiro 京都大学 DOI:10.14989/doctor.k22886

2021.01.25

概要

The reconstruction of lost neural circuits by cell replacement is a possible treatment for neurological deficits after cerebral cortex injury. Cerebral organoids can be a novel source for cell transplantation, but because the cellular composition of the organoids changes along the time course of the development, it remains unclear which developmental stage of the organoids is most suitable for reconstructing the corticospinal tract. Here, we transplanted human embryonic stem cell-derived cerebral organoids at 6 or 10 weeks after differentiation (6w- or 10w-organoids) into mouse cerebral cortices. 6w-organoids extended more axons along the corticospinal tract but caused graft overgrowth with a higher percentage of proliferative cells. Axonal extensions from 10w-organoids were smaller in number but were enhanced when the organoids were grafted 1 week after brain injury. Finally, 10w-organoids extended axons in cynomolgus monkey brains. These results contribute to the development of a cell-replacement therapy for brain injury and stroke.

参考文献

Alcamo, E.A., Chirivella, L., Dautzenberg, M., Dobreva, G., Farinas, I., Grosschedl, R., and McConnell, S.K. (2008). Satb2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 57, 364–377.

Arlotta, P., Molyneaux, B.J., Chen, J., Inoue, J., Kominami, R., and Macklis, J.D. (2005). Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron 45, 207– 221.

Ballout, N., Frappe, I., Peron, S., Jaber, M., Zibara, K., and Gaillard, A. (2016). Development and maturation of embryonic cortical neurons grafted into the damaged adult motor cortex. Front. Neural Circuits 10, 55.

Ballout, N., Rochelle, T., Brot, S., Bonnet, M.L., Francheteau, M., Prestoz, L., Zibara, K., and Gaillard, A. (2019). Characterization of inflammation in delayed cortical transplantation. Front. Mol. Neurosci. 12, 160.

Britanova, O., de Juan Romero, C., Cheung, A., Kwan, K.Y., Schwark, M., Gyorgy, A., Vogel, T., Akopov, S., Mitkovski, M., Agoston, D., et al. (2008). Satb2 is a postmitotic determinant for upperlayer neuron specification in the neocortex. Neuron 57, 378–392.

Chen, H.I., Wolf, J.A., Blue, R., Song, M.M., Moreno, J.D., Ming, G.L., and Song, H. (2019). Transplantation of human brain organoids: revisiting the science and ethics of brain chimeras. Cell Stem Cell 25, 462–472.

Courtine, G., Bunge, M.B., Fawcett, J.W., Grossman, R.G., Kaas, J.H., Lemon, R., Maier, I., Martin, J., Nudo, R.J., Ramon-Cueto, A., et al. (2007). Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans? Nat. Med. 13, 561–566.

Cugola, F.R., Fernandes, I.R., Russo, F.B., Freitas, B.C., Dias, J.L., Guimaraes, K.P., Benazzato, C., Almeida, N., Pignatari, G.C., Romero, S., et al. (2016). The Brazilian Zika virus strain causes birth defects in experimental models. Nature 534, 267–271.

Dang, J., Tiwari, S.K., Lichinchi, G., Qin, Y., Patil, V.S., Eroshkin, A.M., and Rana, T.M. (2016). Zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor TLR3. Cell Stem Cell 19, 258–265.

Daviaud, N., Friedel, R.H., and Zou, H. (2018). Vascularization and engraftment of transplanted human cerebral organoids in mouse cortex. eNeuro 5, ENEURO.0219-18.2018.

Dwyer, N.D., Chen, B., Chou, S.J., Hippenmeyer, S., Nguyen, L., and Ghashghaei, H.T. (2016). Neural stem cells to cerebral cortex: emerging mechanisms regulating progenitor behavior and productivity. J. Neurosci. 36, 11394–11401.

Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., and Sasai, Y. (2008). Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell 3, 519–532.

Espuny-Camacho, I., Michelsen, K.A., Gall, D., Linaro, D., Hasche, A., Bonnefont, J., Bali, C., Orduz, D., Bilheu, A., Herpoel, A., et al. (2013). Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron 77, 440–456.

Espuny-Camacho, I., Michelsen, K.A., Linaro, D., Bilheu, A., Acosta-Verdugo, S., Herpoel, A., Giugliano, M., Gaillard, A., and Vanderhaeghen, P. (2018). Human pluripotent stem-cell-derived cortical neurons integrate functionally into the lesioned adult murine visual cortex in an area-specific way. Cell Rep. 23, 2732–2743.

Fame, R.M., MacDonald, J.L., and Macklis, J.D. (2011). Development, specification, and diversity of callosal projection neurons. Trends Neurosci. 34, 41–50.

Gaillard, F., Domballe, L., and Gaillard, A. (2004). Fetal cortical allografts project massively through the adult cortex. Neuroscience 126, 631–637.

Gaillard, A., Prestoz, L., Dumartin, B., Cantereau, A., Morel, F., Roger, M., and Jaber, M. (2007). Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons. Nat. Neurosci. 10, 1294–1299.

Garcez, P.P., Loiola, E.C., Madeiro da Costa, R., Higa, L.M., Trindade, P., Delvecchio, R., Nascimento, J.M., Brindeiro, R., Tanuri, A., and Rehen, S.K. (2016). Zika virus impairs growth in human neurospheres and brain organoids. Science 352, 816–818.

Gopinath, G., Mahapatra, A.K., Bharadwaj, J.C., Banerji, R., Sharma, D.N., and Tandon, P.N. (1989). Transplantation of fetal neocortex in rhesus monkey. J. Biosci. 14, 255–260.

Grade, S., and Gotz, M. (2017). Neuronal replacement therapy: previous achievements and challenges ahead. NPJ Regen. Med. 2, 29.

Greig, L.C., Woodworth, M.B., Galazo, M.J., Padmanabhan, H., and Macklis, J.D. (2013). Molecular logic of neocortical projection neuron specification, development and diversity. Nat. Rev. Neurosci. 14, 755–769.

Heide, M., Huttner, W.B., and Mora-Bermudez, F. (2018). Brain organoids as models to study human neocortex development and evolution. Curr. Opin. Cell Biol. 55, 8–16.

Hevner, R.F., Daza, R.A., Rubenstein, J.L., Stunnenberg, H., Olavarria, J.F., and Englund, C. (2003). Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons. Dev. Neurosci. 25, 139–151.

Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., and Sasai, Y. (2013). Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. Proc. Natl. Acad. Sci. U S A 110, 20284–20289.

Kwan, K.Y., Sestan, N., and Anton, E.S. (2012). Transcriptional coregulation of neuronal migration and laminar identity in the neocortex. Development 139, 1535–1546.

Lancaster, M.A., Renner, M., Martin, C.A., Wenzel, D., Bicknell, L.S., Hurles, M.E., Homfray, T., Penninger, J.M., Jackson, A.P., and Knoblich, J.A. (2013). Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379.

Lemon, R.N. (2008). Descending pathways in motor control. Annu. Rev. Neurosci. 31, 195–218.

Leyva-Diaz, E., and Lopez-Bendito, G. (2013). In and out from the cortex: development of major forebrain connections. Neuroscience 254, 26–44.

Liauw, J., Hoang, S., Choi, M., Eroglu, C., Choi, M., Sun, G.H., Percy, M., Wildman-Tobriner, B., Bliss, T., Guzman, R.G., et al. (2008). Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke. J. Cereb. Blood Flow Metab. 28, 1722–1732.

Lindvall, O., and Kokaia, Z. (2011). Stem cell research in stroke: how far from the clinic? Stroke 42, 2369–2375.

Mansour, A.A., Goncalves, J.T., Bloyd, C.W., Li, H., Fernandes, S., Quang, D., Johnston, S., Parylak, S.L., Jin, X., and Gage, F.H. (2018). An in vivo model of functional and vascularized human brain organoids. Nat. Biotechnol. 36, 432–441.

Molyneaux, B.J., Arlotta, P., Menezes, J.R., and Macklis, J.D. (2007).

Neuronal subtype specification in the cerebral cortex. Nat. Rev. Neurosci. 8, 427–437.

Palma-Tortosa, S., Tornero, D., Gronning Hansen, M., Monni, E., Hajy, M., Kartsivadze, S., Aktay, S., Tsupykov, O., Parmar, M., Deisseroth, K., et al. (2020). Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior. Proc. Natl. Acad. Sci. U S A 117, 9094–9100.

Peron, S., Droguerre, M., Debarbieux, F., Ballout, N., Benoit-Marand, M., Francheteau, M., Brot, S., Rougon, G., Jaber, M., and Gaillard, A. (2017). A delay between motor cortex lesions and neuronal transplantation enhances graft integration and improves repair and recovery. J. Neurosci. 37, 1820–1834.

Qian, X., Nguyen, H.N., Song, M.M., Hadiono, C., Ogden, S.C., Hammack, C., Yao, B., Hamersky, G.R., Jacob, F., Zhong, C., et al. (2016). Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165, 1238–1254.

Quadrato, G., and Arlotta, P. (2017). Present and future of modeling human brain development in 3D organoids. Curr. Opin. Cell Biol. 49, 47–52.

Sakaguchi, H., Ozaki, Y., Ashida, T., Matsubara, T., Oishi, N., Kihara, S., and Takahashi, J. (2019). Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids. Stem Cell Reports 13, 458–473.

Samata, B., Takaichi, R., Ishii, Y., Fukushima, K., Nakagawa, H., Ono, Y., and Takahashi, J. (2020). L1CAM is a marker for enriching corticospinal motor neurons in the developing brain. Front. Cell. Neurosci. 14, 31.

Sano, N., Shimogawa, T., Sakaguchi, H., Ioroi, Y., Miyawaki, Y., Morizane, A., Miyamoto, S., and Takahashi, J. (2017). Enhanced axonal extension of subcortical projection neurons isolated from murine embryonic cortex using Neuropilin-1. Front. Cell. Neurosci. 11, 123.

Sawai, T., Sakaguchi, H., Thomas, E., Takahashi, J., and Fujita, M. (2019). The ethics of cerebral organoid research: being conscious of consciousness. Stem Cell Reports 13, 440–447.

Skold, M.K., von Gertten, C., Sandberg-Nordqvist, A.C., Mathiesen, T., and Holmin, S. (2005). VEGF and VEGF receptor expression after experimental brain contusion in rat. J. Neurotrauma 22, 353–367.

Suzuki, I.K., and Vanderhaeghen, P. (2015). Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells. Development 142, 3138–3150.

Toma, K., and Hanashima, C. (2015). Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex. Front. Neurosci. 9, 274.

Tornero, D., Wattananit, S., Gronning Madsen, M., Koch, P., Wood, J., Tatarishvili, J., Mine, Y., Ge, R., Monni, E., Devaraju, K., et al. (2013). Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery. Brain 136, 3561–3577.

Tornero, D., Tsupykov, O., Granmo, M., Rodriguez, C., GronningHansen, M., Thelin, J., Smozhanik, E., Laterza, C., Wattananit, S., Ge, R., et al. (2017). Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli. Brain 140, 692–706.

Watanabe, M., Buth, J.E., Vishlaghi, N., de la Torre-Ubieta, L., Taxidis, J., Khakh, B.S., Coppola, G., Pearson, C.A., Yamauchi, K., Gong, D., et al. (2017). Self-organized cerebral organoids with human-specific features predict effective drugs to combat Zika virus infection. Cell Rep. 21, 517–532.

Wuttke, T.V., Markopoulos, F., Padmanabhan, H., Wheeler, A.P., Murthy, V.N., and Macklis, J.D. (2018). Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation. Nat. Neurosci. 21, 517–529.

参考文献をもっと見る

全国の大学の
卒論・修論・学位論文

一発検索!

この論文の関連論文を見る