1. Nagaraju GP, Dontula R, El-Rayes BF, et al. Molecular mechanisms
underlying the divergent roles of SPARC in human carcinogenesis.
Carcinogenesis. 2014;35:967–73.
2. Wong SL, Sukkar MB. The SPARC protein: an overview of its role in lung
cancer and pulmonary fibrosis and its potential role in chronic airways
disease. Br J Pharmacol. 2017;174:3–14.
3. Robert G, Gaggioli C, Bailet O, et al. SPARC represses E-cadherin and induces
mesenchymal transition during melanoma development. Cancer Res. 2006;
66:7516–23.
4. Fenouille N, Tichet M, Dufies M, et al. The epithelial-mesenchymal transition
(EMT) regulatory factor SLUG (SNAI2) is a downstream target of SPARC and
AKT in promoting melanoma cell invasion. PLoS One. 2012;7:e40378.
5. Hung JY, Yen MC, Jian SF, et al. Secreted protein acidic and rich in cysteine
(SPARC) induces cell migration and epithelial mesenchymal transition
through WNK1/snail in non-small cell lung cancer. Oncotarget. 2017;8:
63691–702.
6. Brown TJ, Shaw PA, Karp X, et al. Activation of SPARC expression in reactive
stroma associated with human epithelial ovarian cancer. Gynecol Oncol.
1999;75:25–33.
7. Rodriguez-Jimenez FJ, Caldes T, Iniesta P, et al. Overexpression of SPARC
protein contrasts with its transcriptional silencing by aberrant
hypermethylation of SPARC CpG-rich region in endometrial carcinoma.
Oncol Rep. 2007;17:1301–7.
8. Sato N, Fukushima N, Maehara N, et al. SPARC/osteonectin is a frequent
target for aberrant methylation in pancreatic adenocarcinoma and a
mediator of tumor-stromal interactions. Oncogene. 2003;22:5021–30.
9. Shin M, Mizokami A, Kim J, et al. Exogenous SPARC suppresses proliferation
and migration of prostate cancer by interacting with integrin beta1.
Prostate. 2013;73:1159–70.
10. Infante JR, Matsubayashi H, Sato N, et al. Peritumoral fibroblast SPARC
expression and patient outcome with resectable pancreatic
adenocarcinoma. J Clin Oncol. 2007;25:319–25.
11. Sangaletti S, Stoppacciaro A, Guiducci C, et al. Leukocyte, rather than tumorproduced SPARC, determines stroma and collagen type IV deposition in
mammary carcinoma. J Exp Med. 2003;198:1475–85.
12. Brekken RA, Puolakkainen P, Graves DC, et al. Enhanced growth of tumors in
SPARC null mice is associated with changes in the ECM. J Clin Invest. 2003;
111:487–95.
13. Puolakkainen PA, Brekken RA, Muneer S, et al. Enhanced growth of
pancreatic tumors in SPARC-null mice is associated with decreased
deposition of extracellular matrix and reduced tumor cell apoptosis. Mol
Cancer Res. 2004;2:215–24.
Page 11 of 12
14. Sangaletti S, Di Carlo E, Gariboldi S, et al. Macrophage-derived SPARC
bridges tumor cell-extracellular matrix interactions toward metastasis.
Cancer Res. 2008;68:9050–9.
15. Arnold SA, Rivera LB, Miller AF, et al. Lack of host SPARC enhances vascular
function and tumor spread in an orthotopic murine model of pancreatic
carcinoma. Dis Model Mech. 2010;3:57–72.
16. Said N, Najwer I, Motamed K. Secreted protein acidic and rich in cysteine
(SPARC) inhibits integrin-mediated adhesion and growth factor-dependent
survival signaling in ovarian cancer. Am J Pathol. 2007;170:1054–63.
17. Said N, Frierson HF, Sanchez-Carbayo M, et al. Loss of SPARC in bladder cancer
enhances carcinogenesis and progression. J Clin Invest. 2013;123:751–66.
18. Aycock RL, Bradshaw AC, Sage EH, et al. Development of UV-induced
squamous cell carcinomas is suppressed in the absence of SPARC. J Invest
Dermatol. 2004;123:592–9.
19. Sansom OJ, Mansergh FC, Evans MJ, et al. Deficiency of SPARC suppresses
intestinal tumorigenesis in APCMin/+ mice. Gut. 2007;56:1410–4.
20. Wong SY, Crowley D, Bronson RT, et al. Analyses of the role of endogenous
SPARC in mouse models of prostate and breast cancer. Clin Exp Metastasis.
2008;25:109–18.
21. Sage EH, Reed M, Funk SE, et al. Cleavage of the matricellular protein SPARC
by matrix metalloproteinase 3 produces polypeptides that influence
angiogenesis. J Biol Chem. 2003;278:37849–57.
22. Podgorski I, Linebaugh BE, Koblinski JE, et al. Bone marrow-derived cathepsin K
cleaves SPARC in bone metastasis. Am J Pathol. 2009;175:1255–69.
23. Clark CJ, Sage EH. A prototypic matricellular protein in the tumor
microenvironment--where there's SPARC, there's fire. J Cell Biochem. 2008;
104:721–32.
24. Yusuf N, Inagaki T, Kusunoki S, et al. SPARC was overexpressed in human
endometrial cancer stem-like cells and promoted migration activity.
Gynecol Oncol. 2014;134:356–63.
25. Tomari H, Kawamura T, Asanoma K, et al. Contribution of senescence in
human endometrial stromal cells during proliferative phase to embryo
receptivity†. Biol Reprod. 2020;103:104–13.
26. Zhang N, Wang Y, Liu H, et al. Extracellular vesicle encapsulated microRNA320a inhibits endometrial cancer by suppression of the HIF1α/VEGFA axis.
Exp Cell Res. 2020;394:112113.
27. Aprelikova O, Palla J, Hibler B, et al. Silencing of miR-148a in cancerassociated fibroblasts results in WNT10B-mediated stimulation of tumor cell
motility. Oncogene. 2013;32:3246–53.
28. Aprelikova O, Yu X, Palla J, et al. The role of miR-31 and its target gene
SATB2 in cancer-associated fibroblasts. Cell Cycle. 2010;9:4387–98.
29. Subramaniam KS, Tham ST, Mohamed Z, et al. Cancer-associated fibroblasts
promote proliferation of endometrial cancer cells. PLoS One. 2013;8:e68923.
30. Teng F, Tian WY, Wang YM, et al. Cancer-associated fibroblasts promote the
progression of endometrial cancer via the SDF-1/CXCR4 axis. J Hematol
Oncol. 2016;9:8.
31. Ohmaru-Nakanishi T, Asanoma K, Fujikawa M, et al. Fibrosis in Preeclamptic
placentas is associated with stromal fibroblasts activated by the
transforming growth factor-β1 signaling pathway. Am J Pathol. 2018;188:
683–95.
32. Asanoma K, Liu G, Yamane T, et al. Regulation of the mechanism of TWIST1
transcription by BHLHE40 and BHLHE41 in Cancer cells. Mol Cell Biol. 2015;
35:4096–109.
33. Kalluri R. The biology and function of fibroblasts in cancer. Nat Rev Cancer.
2016;16:582–98.
34. Shi Q, Bao S, Maxwell JA, et al. Secreted protein acidic, rich in cysteine
(SPARC), mediates cellular survival of gliomas through AKT activation. J Biol
Chem. 2004;279:52200–9.
35. Shi Q, Bao S, Song L, et al. Targeting SPARC expression decreases glioma
cellular survival and invasion associated with reduced activities of FAK and
ILK kinases. Oncogene. 2007;26:4084–94.
36. Koukourakis MI, Giatromanolaki A, Brekken RA, et al. Enhanced expression of
SPARC/osteonectin in the tumor-associated stroma of non-small cell lung
cancer is correlated with markers of hypoxia/acidity and with poor
prognosis of patients. Cancer Res. 2003;63:5376–80.
37. Mantoni TS, Schendel RR, Rodel F, et al. Stromal SPARC expression and
patient survival after chemoradiation for non-resectable pancreatic
adenocarcinoma. Cancer Biol Ther. 2008;7:1806–15.
38. Chlenski A, Liu S, Guerrero LJ, et al. SPARC expression is associated with
impaired tumor growth, inhibited angiogenesis and changes in the
extracellular matrix. Int J Cancer. 2006;118:310–6.
Yoshida et al. BMC Cancer
(2021) 21:156
39. Sangaletti S, Tripodo C, Santangelo A, et al. Mesenchymal transition of highgrade breast carcinomas depends on extracellular matrix control of myeloid
suppressor cell activity. Cell Rep. 2016;17:233–48.
40. Zhu J, Wang LY, Li CY, et al. SPARC promotes self-renewal of limbal
epithelial stem cells and ocular surface restoration through JNK and p38MAPK signaling pathways. Stem Cells. 2020;38:134–45.
41. Sharma S, Xing F, Liu Y, et al. Secreted protein acidic and rich in cysteine
(SPARC) mediates metastatic dormancy of prostate Cancer in bone. J Biol
Chem. 2016;291:19351–63.
42. Salzer MC, Lafzi A, Berenguer-Llergo A et al. Identity Noise and Adipogenic
Traits Characterize Dermal Fibroblast Aging. Cell. 2018; 175: 1575–1590.
e1522.
43. Neumann E, Riepl B, Knedla A, et al. Cell culture and passaging alters gene
expression pattern and proliferation rate in rheumatoid arthritis synovial
fibroblasts. Arthritis Res Ther. 2010;12:R83.
44. Dawson K, Wu CT, Qi XY, et al. Congestive heart failure effects on atrial
fibroblast phenotype: differences between freshly-isolated and cultured
cells. PLoS One. 2012;7:e52032.
45. Bauer M, Su G, Casper C, et al. Heterogeneity of gene expression in stromal
fibroblasts of human breast carcinomas and normal breast. Oncogene. 2010;
29:1732–40.
46. Kooistra A, Elissen NM, König JJ, et al. Immunocytochemical characterization
of explant cultures of human prostatic stromal cells. Prostate. 1995;27:42–9.
47. Kusunoki S, Kato K, Tabu K, et al. The inhibitory effect of salinomycin on the
proliferation, migration and invasion of human endometrial cancer stem-like
cells. Gynecol Oncol. 2013;129:598–605.
48. Barker TH, Baneyx G, Cardo-Vila M, et al. SPARC regulates extracellular matrix
organization through its modulation of integrin-linked kinase activity. J Biol
Chem. 2005;280:36483–93.
49. Golembieski WA, Thomas SL, Schultz CR, et al. HSP27 mediates SPARCinduced changes in glioma morphology, migration, and invasion. Glia. 2008;
56:1061–75.
50. Alam R, Schultz CR, Golembieski WA, et al. PTEN suppresses SPARC-induced
pMAPKAPK2 and inhibits SPARC-induced Ser78 HSP27 phosphorylation in
glioma. Neuro-Oncology. 2013;15:451–61.
51. Nagaraju GP, Sharma D. Anti-cancer role of SPARC, an inhibitor of
adipogenesis. Cancer Treat Rev. 2011;37:559–66.
52. Murphy-Ullrich JE. The de-adhesive activity of matricellular proteins: is
intermediate cell adhesion an adaptive state? J Clin Invest. 2001;107:785–90.
53. Levental KR, Yu H, Kass L, et al. Matrix crosslinking forces tumor progression
by enhancing integrin signaling. Cell. 2009;139:891–906.
54. Ng MR, Brugge JS. A stiff blow from the stroma: collagen crosslinking drives
tumor progression. Cancer Cell. 2009;16:455–7.
55. Girotti MR, Fernandez M, Lopez JA, et al. SPARC promotes cathepsin Bmediated melanoma invasiveness through a collagen I/alpha2beta1 integrin
axis. J Invest Dermatol. 2011;131:2438–47.
56. Nakamura K, Yamanouchi K, Nishihara M. Secreted protein acidic and rich in
cysteine internalization and its age-related alterations in skeletal muscle
progenitor cells. Aging Cell. 2014;13:175–84.
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