Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity

概要

Purpose: The purpose oi this study is to evaluate whether PGE-MEM can also be a biomarker of pediatric UC activity and compared its efficacy in predicting UC activity with that of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR).

Methods/Results: Twenty-nine pediatric UC patients (8,18 years) and 29 healthy age- and sex-matched subjects were enrolled. UC activity was evaluated using PUCAI. highest Mayo endoscopic scoring (Mayo), and Matts grading (Matts) for histologic scoring, and the sum of Mayo (total of six segments) and Matts in all patients with UC. PGE-MUM levels were measured using a radioimmunoassay. PGE-MUM levels were elevated in endoscopically and histologically active DC patients, but not in patients with endoscopic and histologic remission or controls. PGE-MUM levels positively and significantly correlated with UC activity. PGE-MUM levels were positively correlated with PUCAI (r = 0. 594), highest Mayo (r = 0. 462), the sum of Mayo (r = 0. 694), and the sum of Matts (r = 0. 613), but not with highest Matts (r = 0. 352). The sum of Mayo and the sum oi Matts, which reflect total colon inflammation. showed highest correlation with PGE-MUM. CRP levels did not correlate with any UC activity scores. ESR exhibited correlation (r = 0.490) with the sum of Mayo only.

Conclusion: PGE-MUM is a reliable biomarker that reflects both the endoscopic and histologic activity of the entire colon in pediatric UC.