Examination of the body composition of patients with Werner syndrome using bioelectrical impedance analysis
概要
Aim
This study performed anthropometric measurements for Werner syndrome (WS) using bioelectrical impedance analysis (BIA) and compared them with the Japanese reference data.
Methods
The analytical sample included nine WS participants (4 males, 5 females, 49.6 ± 9.3 years, SD). The height-corrected appendicular skeletal muscle mass index (SMI), upper- and lower-limb muscle mass index (USMI/LSMI) of WS patients were compared with Japanese reference data (40-79 years). The body mass index (BMI), SMI, height- corrected fat mass index (FMI), and fat-free mass index (FFMI) were compared with the reference data of Japanese older adults (65-94 years). The SMIs of WS were also compared with the diagnostic criteria for sarcopenia.
Results
The SMI and USMI/LSMI of all WS participants were lower than the Japanese reference data corresponding to gender and age, and the rate of decrease was more pronounced for USMI than for LSMI. The BMI, SMI, and FFMI for all the WS cases were lower than those for older Japanese, while the FMI was higher in males with WS but lower in females than the reference data of older Japanese. The SMI was below the cut-off value for the diagnosis of sarcopenia in all the patients with WS.
Conclusion
The SMI for WS is comparable to that for sarcopenia and significantly lower than that for healthy individuals of the same age and older adults. The USMI was significantly lower than LSMI in WS patients, and FMI was higher in male WS patients and lower in females than in healthy older people.